Nars1 asparaginyl-tRNA synthetase 1 [Rattus norvegicus (Norway rat)] - Gene - NCBI

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Nars1 asparaginyl-tRNA synthetase 1 [ Rattus norvegicus (Norway rat) ]
Gene ID: 291556, updated on 9-Dec-2024

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Gene Sequences (FASTA)

Transcript sequences (FASTA)

Protein sequences(FASTA)

In addition, your package will include a detailed data report in both TSV and JSONL formats.

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Summary

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Official Symbol

Nars1provided by RGD

Official Full Name

asparaginyl-tRNA synthetase 1provided by RGD

Primary source

RGD:1307238

See related

EnsemblRapid:ENSRNOG00000017852 AllianceGenome:RGD:1307238

Gene type

protein coding

RefSeq status

VALIDATED

Organism

Rattus norvegicus

Lineage

Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus

Also known as

Nars; LRRGT00113

Summary

Predicted to enable CCR3 chemokine receptor binding activity; asparagine-tRNA ligase activity; and protein dimerization activity. Predicted to be involved in asparaginyl-tRNA aminoacylation; cell migration; and cerebral cortex development. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Orthologous to human NARS1 (asparaginyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Dec 2024]

Expression

Biased expression in Brain (RPKM 412.4), Liver (RPKM 323.2) and 9 other tissues See more

Orthologs

human mouse all

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Genomic context

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See Nars1 in Genome Data Viewer

Location:

18q12.1

Exon count:

15

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Annotation release | Status | Assembly | Chr | Location
RS_2024_02 | current | GRCr8 (GCF_036323735.1) | 18 | NC_086036.1 (60259506..60275782, complement)
RS_2023_06 | previous assembly | mRatBN7.2 (GCF_015227675.2) | 18 | NC_051353.1 (57989308..58005584, complement)
106 | previous assembly | Rnor_6.0 (GCF_000001895.5) | 18 | NC_005117.4 (59986350..60002644, complement)

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Chromosome 18 - NC_086036.1

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:
NC_086036.1 Chromosome 18 Reference GRCr8

NC_051353.1 Chromosome 18 Reference mRatBN7.2 Primary Assembly

NC_005117.4 Chromosome 18 Reference Rnor_6.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

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Expression

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See details

A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages

Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)

BioProject: PRJNA238328

Publication: PMID 24510058

Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

1. Unique N-terminal extension domain of human asparaginyl-tRNA synthetase elicits CCR3-mediated chemokine activity. Park JS, et al. Int J Biol Macromol, 2018 Dec. PMID 30171954

2. Human cytosolic asparaginyl-tRNA synthetase: cDNA sequence, functional expression in Escherichia coli and characterization as human autoantigen. Beaulande M, et al. Nucleic Acids Res, 1998 Jan 15. PMID 9421509, Free PMC Article

3. FMRP recruitment of β-catenin to the translation pre-initiation complex represses translation. Ehyai S, et al. EMBO Rep, 2018 Dec. PMID 30361391, Free PMC Article

4. Analysis of oxygen/glucose-deprivation-induced changes in SUMO3 conjugation using SILAC-based quantitative proteomics. Yang W, et al. J Proteome Res, 2012 Feb 3. PMID 22082260, Free PMC Article

5. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
Submit: New GeneRIF Correction

Interactions

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Products | Interactant | Other Gene | Complex | Source | Pubs | Description
BioGRID:253557 | BioGRID:249913 | Ctnnb1 | | BioGRID | PubMed | Affinity Capture-MS
BioGRID:253557 | BioGRID:270726 | Sumo3 | | BioGRID | PubMed | Affinity Capture-MS

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General gene information

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Markers

RH127915 (e-PCR)

UniSTS:211225

AI045751 (e-PCR)

UniSTS:248402

Homology

NCBI Orthologs
Orthologs from OrthoDB

Clone Names

MGC116236

Gene Ontology Provided by RGD

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Function | Evidence Code | Pubs

enables ATP binding

IEA
Inferred from Electronic Annotation
more info

enables CCR3 chemokine receptor binding

ISO
Inferred from Sequence Orthology
more info

enables asparagine-tRNA ligase activity

IBA
Inferred from Biological aspect of Ancestor
more info

enables asparagine-tRNA ligase activity

ISO
Inferred from Sequence Orthology
more info

enables nucleic acid binding

IEA
Inferred from Electronic Annotation
more info

enables protein dimerization activity

ISO
Inferred from Sequence Orthology
more info

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Process | Evidence Code | Pubs

involved_in asparaginyl-tRNA aminoacylation

IBA
Inferred from Biological aspect of Ancestor
more info

involved_in asparaginyl-tRNA aminoacylation

ISO
Inferred from Sequence Orthology
more info

involved_in cell migration

ISO
Inferred from Sequence Orthology
more info

involved_in cerebral cortex development

ISO
Inferred from Sequence Orthology
more info

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Component | Evidence Code | Pubs

is_active_in cytoplasm

IBA
Inferred from Biological aspect of Ancestor
more info

located_in cytosol

IEA
Inferred from Electronic Annotation
more info

located_in cytosol

ISO
Inferred from Sequence Orthology
more info

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General protein information

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Preferred Names

asparagine--tRNA ligase, cytoplasmic

Names

asparaginyl-tRNA synthetase, cytoplasmic

NP_001020806.2

EC 6.1.1.22

NP_001136421.1

EC 6.1.1.22

NP_001385496.1

EC 6.1.1.22

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

1. NM_001025635.3 → NP_001020806.2 asparagine--tRNA ligase, cytoplasmic isoform 1

See identical proteins and their annotated locations for NP_001020806.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

JAXUCZ010000018

UniProtKB/TrEMBL

A0A0G2JUE7, A6IXP1, F1LPV0

Conserved Domains (3) summary

COG0017
Location:135 → 558

AsnS; Aspartyl/asparaginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]

cd00776
Location:235 → 554

AsxRS_core; Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as ...

cd04323
Location:137 → 219

AsnRS_cyto_like_N; AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a ...

2. NM_001142949.2 → NP_001136421.1 asparagine--tRNA ligase, cytoplasmic isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks two alternate in-frame exons and uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The resulting isoform (2) has several differences near the N-terminus, compared to isoform 1.

Source sequence(s)

JAXUCZ010000018

UniProtKB/TrEMBL

F1LML0, Q6TUD1

Related

ENSRNOP00000055935.2, ENSRNOT00000059162.6

Conserved Domains (3) summary

COG0017
Location:84 → 507

AsnS; Aspartyl/asparaginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]

cd00776
Location:184 → 503

AsxRS_core; Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as ...

cd04323
Location:86 → 168

AsnRS_cyto_like_N; AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a ...

3. NM_001398567.1 → NP_001385496.1 asparagine--tRNA ligase, cytoplasmic isoform 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000018

UniProtKB/TrEMBL

A0A0G2JUE7

Related

ENSRNOP00000024264.7, ENSRNOT00000024264.10

Conserved Domains (1) summary

COG0017
Location:136 → 559

AsnS; Aspartyl/asparaginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

This section includes genomic Reference Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate assemblies. Model RNAs and proteins are also reported here.

Reference GRCr8

Genomic

1. NC_086036.1 Reference GRCr8

Range

60259506..60275782 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

Related sequences

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Nucleotide | Protein | Strain
Heading | Accession and Version
genomic | CH473971.1 | EDM14674.1
genomic | JAXUCZ010000018.1 (60259506..60275782) | None | BN/NHsdMcwi
mRNA | AY387099.1 | AAQ91069.1 | Sprague-Dawley
mRNA | BC099099.1 | AAH99099.1
mRNA | CB578784.1 | None

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Additional links

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Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information

MilliporeSigma

NARS products

Molecular Biology Databases

Bgee database

Nars1 gene expression

BioGPS

BioGPS

GlyGen glycoinformatics resource

GlyGen glycoinformatics resource

Ingenuity Pathways Analysis

Ingenuity Pathways Analysis

Kyoto Encyclopedia of Genes and Genomes

Kyoto Encyclopedia of Genes and Genomes

OMA Browser: Orthologous MAtrix

OMA Browser: Orthologous MAtrix

OMA Browser: Orthologous MAtrix

OrthoDB catalog of orthologs

Orthologs

PhosphoSitePlus

PhosphoSitePlus® - comprehensive post-translational modification resource

Research Materials

Addgene Non-profit plasmid repository

Get Plasmids - Addgene

ExactAntigen/Labome

reagents

GenScript latest version of gene cDNA ORF Clone

GenScript latest version of gene cDNA ORF Clone

GeneCopoeia Inc.

Order TALEN/CRISPR clones

OriGene

Order Nars cDNA clone/Protein/Antibody/RNAi

Tools

GeneMANIA

GeneMANIA

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Supplemental Content

Table of contents

Summary

Genomic context

Genomic regions, transcripts, and products

Expression

Bibliography

Interactions

General gene information
Markers, Clone Names, Homology, Gene Ontology

General protein information

NCBI Reference Sequences (RefSeq)

Related sequences

Additional links

Genome Browsers

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Related information

BioProjects
BioProjects related to a gene

BioSystems
BioSystems

Conserved Domains
Related CDD

Full text in PMC
PMC links

Full text in PMC_nucleotide
Full text in PubMedCentral identified from shared sequence links

Functional Class
Functional class of the sequence domain architecture

Gene neighbors
Overlapping genes and two nearest non-overlapping genes on either side

Genome
Related Genome

GEO Profiles
Related GEO

Nucleotide
Link to related Nucleotide entry

Probe
Related Probe entry

Protein
Link to related protein entry

PubChem Compound
PubChem Compounds

PubChem Substance
PubChem Substances

PubMed
Link to related PubMed entry

PubMed(nucleotide/PMC)
Citations in PubMed identified from shared sequence and PMC links.

RefSeq Proteins
Link to Protein RefSeqs

RefSeq RNAs
Link to Nucleotide RefSeq RNAs

Taxonomy
Link to related taxonomy entry

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Nars1 asparaginyl-tRNA synthetase 1 [Rattus norvegicus]
Nars1 asparaginyl-tRNA synthetase 1 [Rattus norvegicus]
Gene ID:291556

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