Tor1aip1 torsin 1A interacting protein 1 [Rattus norvegicus (Norway rat)] - Gene - NCBI

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Tor1aip1 torsin 1A interacting protein 1 [ Rattus norvegicus (Norway rat) ]
Gene ID: 246314, updated on 9-Dec-2024

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Gene Sequences (FASTA)

Transcript sequences (FASTA)

Protein sequences(FASTA)

In addition, your package will include a detailed data report in both TSV and JSONL formats.

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Summary

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Official Symbol

Tor1aip1provided by RGD

Official Full Name

torsin 1A interacting protein 1provided by RGD

Primary source

RGD:628851

See related

EnsemblRapid:ENSRNOG00000003946 AllianceGenome:RGD:628851

Gene type

protein coding

RefSeq status

PROVISIONAL

Organism

Rattus norvegicus

Lineage

Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus

Also known as

Lap1b; Lap1c

Summary

Enables lamin binding activity. Predicted to be involved in nuclear membrane organization; positive regulation of ATP-dependent activity; and protein localization to nucleus. Predicted to act upstream of or within protein localization to nuclear envelope. Located in nuclear envelope. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy type 2Y. Orthologous to human TOR1AIP1 (torsin 1A interacting protein 1). [provided by Alliance of Genome Resources, Dec 2024]

Expression

Biased expression in Testes (RPKM 163.5), Adrenal (RPKM 160.1) and 9 other tissues See more

Orthologs

human mouse all

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Genomic context

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See Tor1aip1 in Genome Data Viewer

Location:

13q22

Exon count:

12

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Annotation release | Status | Assembly | Chr | Location
RS_2024_02 | current | GRCr8 (GCF_036323735.1) | 13 | NC_086031.1 (70746941..70776382, complement)
RS_2023_06 | previous assembly | mRatBN7.2 (GCF_015227675.2) | 13 | NC_051348.1 (68196681..68226121, complement)
106 | previous assembly | Rnor_6.0 (GCF_000001895.5) | 13 | NC_005112.4 (73670649..73704668, complement)

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Chromosome 13 - NC_086031.1

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:
NC_086031.1 Chromosome 13 Reference GRCr8

NC_051348.1 Chromosome 13 Reference mRatBN7.2 Primary Assembly

NC_005112.4 Chromosome 13 Reference Rnor_6.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

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Expression

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See details

A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages

Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)

BioProject: PRJNA238328

Publication: PMID 24510058

Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

1. cDNA cloning and characterization of lamina-associated polypeptide 1C (LAP1C), an integral protein of the inner nuclear membrane. Martin L, et al. J Biol Chem, 1995 Apr 14. PMID 7721789

2. Dystonia-causing mutant torsinA inhibits cell adhesion and neurite extension through interference with cytoskeletal dynamics. Hewett JW, et al. Neurobiol Dis, 2006 Apr. PMID 16361107

3. Arresting a Torsin ATPase reshapes the endoplasmic reticulum. Rose AE, et al. J Biol Chem, 2014 Jan 3. PMID 24275647, Free PMC Article

4. Proteome analysis of a rat liver nuclear insoluble protein fraction and localization of a novel protein, ISP36, to compartments in the interchromatin space. Segawa M, et al. FEBS J, 2005 Sep. PMID 16128803

5. The nuclear envelope protein, LAP1B, is a novel protein phosphatase 1 substrate. Santos M, et al. PLoS One, 2013. PMID 24116158, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

1. Data indicate that the protein phosphatase 1 (PP1) and nuclear membrane protein lamina associated polypeptide 1B (LAP1B) LAP1B:PP1 complex can be immunoprecipitated from cerebral cortex.
Title: The nuclear envelope protein, LAP1B, is a novel protein phosphatase 1 substrate.

Submit: New GeneRIF Correction

General gene information

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Markers

RH129301 (e-PCR)

UniSTS:212608

Homology

NCBI Orthologs
Orthologs from OrthoDB

Clone Names

MGC93149

Gene Ontology Provided by RGD

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Function | Evidence Code | Pubs

enables ATPase activator activity

IEA
Inferred from Electronic Annotation
more info

enables ATPase activator activity

ISO
Inferred from Sequence Orthology
more info

enables ATPase activator activity

ISS
Inferred from Sequence or Structural Similarity
more info

enables ATPase binding

ISO
Inferred from Sequence Orthology
more info

enables cytoskeletal protein binding

ISO
Inferred from Sequence Orthology
more info

enables lamin binding

IDA
Inferred from Direct Assay
more info

PubMed

enables protein binding

IPI
Inferred from Physical Interaction
more info

PubMed

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Process | Evidence Code | Pubs

involved_in nuclear membrane organization

IBA
Inferred from Biological aspect of Ancestor
more info

acts_upstream_of_or_within nuclear membrane organization

ISO
Inferred from Sequence Orthology
more info

involved_in positive regulation of ATP-dependent activity

ISO
Inferred from Sequence Orthology
more info

involved_in positive regulation of ATP-dependent activity

ISS
Inferred from Sequence or Structural Similarity
more info

acts_upstream_of_or_within protein localization to nuclear envelope

ISO
Inferred from Sequence Orthology
more info

involved_in protein localization to nucleus

ISS
Inferred from Sequence or Structural Similarity
more info

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Component | Evidence Code | Pubs

located_in nuclear envelope

IDA
Inferred from Direct Assay
more info

PubMed

located_in nuclear envelope

ISO
Inferred from Sequence Orthology
more info

located_in nuclear inner membrane

IEA
Inferred from Electronic Annotation
more info

is_active_in nuclear membrane

IBA
Inferred from Biological aspect of Ancestor
more info

located_in nuclear membrane

ISO
Inferred from Sequence Orthology
more info

located_in nucleus

ISO
Inferred from Sequence Orthology
more info

located_in nucleus

ISS
Inferred from Sequence or Structural Similarity
more info

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General protein information

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Preferred Names

torsin-1A-interacting protein 1

Names

lamina-associated polypeptide 1B

lamina-associated polypeptide 1C

torsin A interacting protein 1

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

1. NM_145092.2 → NP_659560.2 torsin-1A-interacting protein 1

See identical proteins and their annotated locations for NP_659560.2

Status: PROVISIONAL

Source sequence(s)

BC086987

UniProtKB/Swiss-Prot

Q5PQX1, Q62741, Q62754

UniProtKB/TrEMBL

A0A8I6AGC6, A6ICZ9

Related

ENSRNOP00000005280.4, ENSRNOT00000005280.8

Conserved Domains (1) summary

pfam05609
Location:162 → 582

LAP1C; Lamina-associated polypeptide 1C (LAP1C)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

This section includes genomic Reference Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate assemblies. Model RNAs and proteins are also reported here.

Reference GRCr8

Genomic

1. NC_086031.1 Reference GRCr8

Range

70746941..70776382 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

1. XM_039090334.2 → XP_038946262.1 torsin-1A-interacting protein 1 isoform X1

UniProtKB/TrEMBL

A0A8I6A2B4, A0A8I6AGC6

Related

ENSRNOP00000085745.1, ENSRNOT00000098741.2

Conserved Domains (1) summary

pfam05609
Location:162 → 547

LAP1C; Lamina-associated polypeptide 1C (LAP1C)

2. XM_006250028.5 → XP_006250090.1 torsin-1A-interacting protein 1 isoform X2

See identical proteins and their annotated locations for XP_006250090.1

Conserved Domains (1) summary

pfam05609
Location:1 → 395

LAP1C; Lamina-associated polypeptide 1C (LAP1C)

3. XM_006250027.5 → XP_006250089.1 torsin-1A-interacting protein 1 isoform X2

See identical proteins and their annotated locations for XP_006250089.1

Conserved Domains (1) summary

pfam05609
Location:1 → 395

LAP1C; Lamina-associated polypeptide 1C (LAP1C)

Related sequences

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Nucleotide | Protein | Strain
Heading | Accession and Version
genomic | CH473958.2 | EDM09497.1
| EDM09498.1
| EDM09499.1
genomic | JAXUCZ010000013.1 (70746941..70776382) | None | BN/NHsdMcwi
mRNA | BC086987.1 | AAH86987.1
mRNA | FQ234456.1 | None | Sprague-Dawley
mRNA | U19614.1 | AAA69914.1 | Sprague-Dawley
mRNA | U20286.1 | AAA69915.1 | Sprague-Dawley

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Protein Accession | Links
GenPept Link | UniProtKB Link
Q5PQX1.1 | GenPept | UniProtKB/Swiss-Prot:Q5PQX1

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Additional links

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Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information

Interologous Interaction Database

Interologous Interaction Database

MilliporeSigma

Tor1aip1 products

Molecular Biology Databases

Bgee database

Tor1aip1 gene expression

BioGPS

BioGPS

CTD: Comparative Toxicogenomics Database

CTD: Comparative Toxicogenomics Database - TOR1AIP1

GlyGen glycoinformatics resource

GlyGen glycoinformatics resource

Ingenuity Pathways Analysis

Ingenuity Pathways Analysis

Kyoto Encyclopedia of Genes and Genomes

Kyoto Encyclopedia of Genes and Genomes

OMA Browser: Orthologous MAtrix

OMA Browser: Orthologous MAtrix

OMA Browser: Orthologous MAtrix

OrthoDB catalog of orthologs

Orthologs

PhosphoSitePlus

PhosphoSitePlus® - comprehensive post-translational modification resource

Research Materials

Addgene Non-profit plasmid repository

Get Plasmids - Addgene

ExactAntigen/Labome

reagents

GenScript latest version of gene cDNA ORF Clone

GenScript latest version of gene cDNA ORF Clone

GeneCopoeia Inc.

Order TALEN/CRISPR clones

OriGene

Order TOR1AIP1 cDNA clone/Protein/Antibody/RNAi

Tools

GeneMANIA

GeneMANIA

Miscellaneous

Reactome

Reactome Event:Signal Transduction

Reactome Entity:Q5PQX1

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Supplemental Content

Table of contents

Summary

Genomic context

Genomic regions, transcripts, and products

Expression

Bibliography

General gene information
Markers, Clone Names, Homology, Gene Ontology

General protein information

NCBI Reference Sequences (RefSeq)

Related sequences

Additional links

Genome Browsers

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Related information

BioProjects
BioProjects related to a gene

Conserved Domains
Related CDD

Full text in PMC
PMC links

Full text in PMC_nucleotide
Full text in PubMedCentral identified from shared sequence links

Functional Class
Functional class of the sequence domain architecture

Gene neighbors
Overlapping genes and two nearest non-overlapping genes on either side

Genome
Related Genome

GEO Profiles
Related GEO

Nucleotide
Link to related Nucleotide entry

Probe
Related Probe entry

Protein
Link to related protein entry

PubChem Compound
PubChem Compounds

PubChem Substance
PubChem Substances

PubMed
Link to related PubMed entry

PubMed (GeneRIF)
Link to related PubMed article from GeneRIFs

PubMed(nucleotide/PMC)
Citations in PubMed identified from shared sequence and PMC links.

RefSeq Proteins
Link to Protein RefSeqs

RefSeq RNAs
Link to Nucleotide RefSeq RNAs

Taxonomy
Link to related taxonomy entry

Links to other resources

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UCSC

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Tor1aip1 torsin 1A interacting protein 1 [Rattus norvegicus]
Tor1aip1 torsin 1A interacting protein 1 [Rattus norvegicus]
Gene ID:246314

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