Glra2 glycine receptor, alpha 2 [Rattus norvegicus (Norway rat)] - Gene - NCBI

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Glra2 glycine receptor, alpha 2 [ Rattus norvegicus (Norway rat) ]
Gene ID: 24397, updated on 9-Dec-2024

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Gene Sequences (FASTA)

Transcript sequences (FASTA)

Protein sequences(FASTA)

In addition, your package will include a detailed data report in both TSV and JSONL formats.

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Summary

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Symbol

Glra2provided by RGD

Full Name

glycine receptor, alpha 2provided by RGD

Primary source

RGD:2705

See related

EnsemblRapid:ENSRNOG00000003313 AllianceGenome:RGD:2705

Gene type

protein coding

RefSeq status

VALIDATED

Organism

Rattus norvegicus

Lineage

Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus

Also known as

RNNEOGLY

Summary

Predicted to enable extracellular ligand-gated monoatomic ion channel activity and glycine binding activity. Predicted to contribute to chloride channel activity. Involved in spinal cord development and synapse assembly. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be part of transmembrane transporter complex. Predicted to be active in several cellular components, including GABA-ergic synapse; glycinergic synapse; and postsynaptic specialization membrane. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability Pilorge type. Orthologous to human GLRA2 (glycine receptor alpha 2). [provided by Alliance of Genome Resources, Dec 2024]

Expression

Restricted expression toward (RPKM 36.0) See more

Orthologs

human mouse all

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Genomic context

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See Glra2 in Genome Data Viewer

Location:

Xq14

Exon count:

11

Items 1 - 3 of 3

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Annotation release | Status | Assembly | Chr | Location
RS_2024_02 | current | GRCr8 (GCF_036323735.1) | X | NC_086039.1 (32651931..32873277)
RS_2023_06 | previous assembly | mRatBN7.2 (GCF_015227675.2) | X | NC_051356.1 (29020377..29241666)
106 | previous assembly | Rnor_6.0 (GCF_000001895.5) | X | NC_005120.4 (30612894..30832078, complement)

Items 1 - 3 of 3

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Chromosome X - NC_086039.1

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:
NC_086039.1 Chromosome X Reference GRCr8

NC_051356.1 Chromosome X Reference mRatBN7.2 Primary Assembly

NC_005120.4 Chromosome X Reference Rnor_6.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

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Expression

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See details

A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages

Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)

BioProject: PRJNA238328

Publication: PMID 24510058

Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

1. Gating effects on picrotin block of glycine receptors. Li P, et al. Neuroreport, 2012 Dec 5. PMID 23079787

2. Changes in glycine receptor subunit expression in forebrain regions of the Wistar rat over development. Jonsson S, et al. Brain Res, 2012 Mar 29. PMID 22330726

3. Developmental expression of glycine receptor subunits in rat cerebellum. García-Alcocer G, et al. Int J Dev Neurosci, 2008 May-Jun. PMID 18339511

4. A single amino acid exchange alters the pharmacology of neonatal rat glycine receptor subunit. Kuhse J, et al. Neuron, 1990 Dec. PMID 2176511

5. Cloning of a glycine receptor subtype expressed in rat brain and spinal cord during a specific period of neuronal development. Akagi H, et al. FEBS Lett, 1991 Apr 9. PMID 1707830

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

1. Streptozotocin-Induced Diabetic Rats Showed a Differential Glycine Receptor Expression in the Spinal Cord: A GlyR Role in Diabetic Neuropathy.
Title: Streptozotocin-Induced Diabetic Rats Showed a Differential Glycine Receptor Expression in the Spinal Cord: A GlyR Role in Diabetic Neuropathy.

2. data show that the current-voltage relationships of homomeric channels formed by the alpha2 or alpha3 subunits change upon receptor desensitization from a linear to an inwardly rectifying shape, in contrast to their heteromeric counterparts.
Title: Electrophysiological Signature of Homomeric and Heteromeric Glycine Receptor Channels.

3. alpha2 subunits determine the picrotin sensitivity of alpha1alpha2-heteromeric receptors. Direct gating of the alpha2 subunit is not required for this picrotin inhibition.
Title: Gating effects on picrotin block of glycine receptors.

4. This study demonistrated that glycine receptor alpha 2 subunit decrease in developmental brain.
Title: Changes in glycine receptor subunit expression in forebrain regions of the Wistar rat over development.

5. The immunohistochemistry indicated a strong Glycine receptor alpha2 signal in the Purkinje cells, internal and external granular layers.
Title: Developmental expression of glycine receptor subunits in rat cerebellum.

6. Role of Nova-1 in regulating alpha2N, a novel glycine receptor splice variant, in developing spinal cord neurons.
Title: Role of Nova-1 in regulating alpha2N, a novel glycine receptor splice variant, in developing spinal cord neurons.

Submit: New GeneRIF Correction

General gene information

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Markers

D5S648 (e-PCR), detects polymorphism

UniSTS:13873

GLRA2 (e-PCR)

UniSTS:506517

Homology

NCBI Orthologs
Orthologs from OrthoDB

Gene Ontology Provided by RGD

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Function | Evidence Code | Pubs

contributes_to chloride channel activity

IBA
Inferred from Biological aspect of Ancestor
more info

enables chloride channel activity

IEA
Inferred from Electronic Annotation
more info

enables excitatory extracellular ligand-gated monoatomic ion channel activity

IBA
Inferred from Biological aspect of Ancestor
more info

enables extracellularly glycine-gated chloride channel activity

IEA
Inferred from Electronic Annotation
more info

enables extracellularly glycine-gated chloride channel activity

ISO
Inferred from Sequence Orthology
more info

enables extracellularly glycine-gated chloride channel activity

TAS
Traceable Author Statement
more info

PubMed

enables glycine binding

IEA
Inferred from Electronic Annotation
more info

enables glycine binding

ISO
Inferred from Sequence Orthology
more info

enables glycine-gated chloride ion channel activity

IEA
Inferred from Electronic Annotation
more info

enables glycine-gated chloride ion channel activity

ISO
Inferred from Sequence Orthology
more info

enables metal ion binding

IEA
Inferred from Electronic Annotation
more info

enables transmembrane signaling receptor activity

IEA
Inferred from Electronic Annotation
more info

enables transmitter-gated monoatomic ion channel activity

IEA
Inferred from Electronic Annotation
more info

enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

IEA
Inferred from Electronic Annotation
more info

enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

ISO
Inferred from Sequence Orthology
more info

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Process | Evidence Code | Pubs

involved_in cellular response to amino acid stimulus

IEA
Inferred from Electronic Annotation
more info

involved_in cellular response to amino acid stimulus

ISO
Inferred from Sequence Orthology
more info

involved_in cellular response to ethanol

IEA
Inferred from Electronic Annotation
more info

involved_in cellular response to ethanol

ISO
Inferred from Sequence Orthology
more info

involved_in cellular response to zinc ion

IEA
Inferred from Electronic Annotation
more info

involved_in cellular response to zinc ion

ISO
Inferred from Sequence Orthology
more info

involved_in chloride transmembrane transport

IBA
Inferred from Biological aspect of Ancestor
more info

involved_in chloride transmembrane transport

IEA
Inferred from Electronic Annotation
more info

involved_in chloride transmembrane transport

ISO
Inferred from Sequence Orthology
more info

involved_in excitatory postsynaptic potential

IEA
Inferred from Electronic Annotation
more info

involved_in modulation of chemical synaptic transmission

IEA
Inferred from Electronic Annotation
more info

involved_in modulation of chemical synaptic transmission

ISO
Inferred from Sequence Orthology
more info

involved_in monoatomic ion transmembrane transport

ISO
Inferred from Sequence Orthology
more info

involved_in neuropeptide signaling pathway

IEA
Inferred from Electronic Annotation
more info

involved_in neuropeptide signaling pathway

ISO
Inferred from Sequence Orthology
more info

involved_in spinal cord development

IEP
Inferred from Expression Pattern
more info

PubMed

involved_in synapse assembly

IEP
Inferred from Expression Pattern
more info

PubMed

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Items 1 - 12 of 12

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Component | Evidence Code | Pubs

located_in GABA-ergic synapse

IEA
Inferred from Electronic Annotation
more info

is_active_in GABA-ergic synapse

ISO
Inferred from Sequence Orthology
more info

located_in cell projection

IEA
Inferred from Electronic Annotation
more info

part_of chloride channel complex

IEA
Inferred from Electronic Annotation
more info

located_in glycinergic synapse

IEA
Inferred from Electronic Annotation
more info

is_active_in glycinergic synapse

ISO
Inferred from Sequence Orthology
more info

located_in intracellular membrane-bounded organelle

IEA
Inferred from Electronic Annotation
more info

located_in intracellular membrane-bounded organelle

ISO
Inferred from Sequence Orthology
more info

located_in plasma membrane

ISO
Inferred from Sequence Orthology
more info

located_in postsynaptic membrane

IEA
Inferred from Electronic Annotation
more info

located_in postsynaptic specialization membrane

IEA
Inferred from Electronic Annotation
more info

is_active_in postsynaptic specialization membrane

ISO
Inferred from Sequence Orthology
more info

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General protein information

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Preferred Names

glycine receptor subunit alpha-2

Names

Glycine receptor alpha 2 subunit (glycine receptor, neonatal)

glycine receptor strychnine-binding subunit

glycine receptor subunit alpha-2-like

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

1. NM_012568.5 → NP_036700.1 glycine receptor subunit alpha-2 precursor

See identical proteins and their annotated locations for NP_036700.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021

UniProtKB/Swiss-Prot

P22771, Q91W28

UniProtKB/TrEMBL

A0A0G2JSH7, A6K2J6

Related

ENSRNOP00000004443.4, ENSRNOT00000004443.8

Conserved Domains (1) summary

TIGR00860
Location:46 → 441

LIC; Cation transporter family protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

This section includes genomic Reference Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate assemblies. Model RNAs and proteins are also reported here.

Reference GRCr8

Genomic

1. NC_086039.1 Reference GRCr8

Range

32651931..32873277

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

1. XM_003752039.6 → XP_003752087.1 glycine receptor subunit alpha-2 isoform X1

See identical proteins and their annotated locations for XP_003752087.1

UniProtKB/Swiss-Prot

P22771, Q91W28

UniProtKB/TrEMBL

A0A0G2JSH7, A6K2J6

Conserved Domains (1) summary

TIGR00860
Location:46 → 441

LIC; Cation transporter family protein

2. XM_008773152.4 → XP_008771374.1 glycine receptor subunit alpha-2 isoform X2

See identical proteins and their annotated locations for XP_008771374.1

UniProtKB/Swiss-Prot

P22771, Q91W28

UniProtKB/TrEMBL

A0A8I6GJI2

Related

ENSRNOP00000091317.1, ENSRNOT00000111367.2

Conserved Domains (1) summary

TIGR00860
Location:46 → 441

LIC; Cation transporter family protein

3. XM_039099446.2 → XP_038955374.1 glycine receptor subunit alpha-2 isoform X3

UniProtKB/TrEMBL

A0A8I5ZW10

Conserved Domains (1) summary

TIGR00860
Location:11 → 361

LIC; Cation transporter family protein

Related sequences

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Nucleotide | Protein | Strain
Heading | Accession and Version
genomic | AABR07037787.1 (44105..138233) | None | mixed
genomic | AABR07037788.1 | None | mixed
genomic | AABR07037789.1 | None | mixed
genomic | AABR07037790.1 | None | mixed
genomic | AABR07037791.1 | None | mixed
genomic | CH474014.2 | EDL90533.1
genomic | JAXUCZ010000021.1 (32651931..32873277) | None | BN/NHsdMcwi
mRNA | AF374197.1 | None | Sprague-Dawley
mRNA | AJ310837.1 | CAC35981.1 | Sprague-Dawley
mRNA | CB715572.1 | None
mRNA | X61159.1 | CAA43471.1

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Protein Accession | Links
GenPept Link | UniProtKB Link
P22771.1 | GenPept | UniProtKB/Swiss-Prot:P22771

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Additional links

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Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information

Interologous Interaction Database

Interologous Interaction Database

MilliporeSigma

Glra2 products

Molecular Biology Databases

Bgee database

Glra2 gene expression

BioGPS

BioGPS

GlyGen glycoinformatics resource

GlyGen glycoinformatics resource

Guide to Pharmacology

glycine receptor alpha2 subunit gene

Ingenuity Pathways Analysis

Ingenuity Pathways Analysis

Kyoto Encyclopedia of Genes and Genomes

Kyoto Encyclopedia of Genes and Genomes

OMA Browser: Orthologous MAtrix

OMA Browser: Orthologous MAtrix

OMA Browser: Orthologous MAtrix

OrthoDB catalog of orthologs

Orthologs

PhosphoSitePlus

PhosphoSitePlus® - comprehensive post-translational modification resource

Research Materials

Addgene Non-profit plasmid repository

Get Plasmids - Addgene

ExactAntigen/Labome

reagents

GenScript latest version of gene cDNA ORF Clone

GenScript latest version of gene cDNA ORF Clone

GeneCopoeia Inc.

Order TALEN/CRISPR clones

OriGene

Order Glra2 cDNA clone/Protein/Antibody/RNAi

Tools

GeneMANIA

GeneMANIA

Miscellaneous

Reactome

Reactome Entity:P22771

Reactome Event:Neuronal System

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Supplemental Content

Table of contents

Summary

Genomic context

Genomic regions, transcripts, and products

Expression

Bibliography

General gene information
Markers, Homology, Gene Ontology

General protein information

NCBI Reference Sequences (RefSeq)

Related sequences

Additional links

Genome Browsers

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Related information

BioAssay by Target (List)
BioAssays related to the gene by protein target or RNAi target

BioAssay by Target (Summary)
Summarized PubChem Data on the gene, showing the active data by default

BioProjects
BioProjects related to a gene

BioSystems
BioSystems

Conserved Domains
Related CDD

Full text in PMC
PMC links

Full text in PMC_nucleotide
Full text in PubMedCentral identified from shared sequence links

Functional Class
Functional class of the sequence domain architecture

Gene neighbors
Overlapping genes and two nearest non-overlapping genes on either side

Genome
Related Genome

GEO Profiles
Related GEO

Nucleotide
Link to related Nucleotide entry

Probe
Related Probe entry

Protein
Link to related protein entry

PubChem Compound
PubChem Compounds

PubChem Substance
PubChem Substances

PubMed
Link to related PubMed entry

PubMed (GeneRIF)
Link to related PubMed article from GeneRIFs

PubMed(nucleotide/PMC)
Citations in PubMed identified from shared sequence and PMC links.

RefSeq Proteins
Link to Protein RefSeqs

RefSeq RNAs
Link to Nucleotide RefSeq RNAs

Taxonomy
Link to related taxonomy entry

Links to other resources

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AllianceGenome

UCSC

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Glra2 glycine receptor, alpha 2 [Rattus norvegicus]
Glra2 glycine receptor, alpha 2 [Rattus norvegicus]
Gene ID:24397

Gene

PMC Links for GEO Profiles (Select 57978449) (20)
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