U.S. flag

An official website of the United States government

Nmnat2 nicotinamide nucleotide adenylyltransferase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 289095, updated on 9-Dec-2024

Summary

Official Symbol
Nmnat2provided by RGD
Official Full Name
nicotinamide nucleotide adenylyltransferase 2provided by RGD
Primary source
RGD:1307331
See related
EnsemblRapid:ENSRNOG00000027697 AllianceGenome:RGD:1307331
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable nicotinamide-nucleotide adenylyltransferase activity; nicotinate-nucleotide adenylyltransferase activity; and protein ADP-ribosyltransferase-substrate adaptor activity. Involved in NAD biosynthetic process and cellular response to angiotensin. Predicted to be located in several cellular components, including cytosol; late endosome; and trans-Golgi network. Predicted to be active in Golgi apparatus. Biomarker of hypertrophic cardiomyopathy. Orthologous to human NMNAT2 (nicotinamide nucleotide adenylyltransferase 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Brain (RPKM 184.4), Lung (RPKM 21.7) and 1 other tissue See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Nmnat2 in Genome Data Viewer
Location:
13q21
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (67655794..67831609)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (65105950..65277350)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (70379346..70559311)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481571 Neighboring gene ribosomal protein L15, pseudogene 5 Neighboring gene ribosomal protein S2, pseudogene 37 Neighboring gene uncharacterized LOC120096279 Neighboring gene laminin subunit gamma 2 Neighboring gene laminin subunit gamma 1 Neighboring gene ornithine decarboxylase-like

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Pathways from PubChem

General gene information

Gene Ontology Provided by RGD

Component Evidence Code Pubs
is_active_in Golgi apparatus  
located_in Golgi apparatus  
located_in Golgi membrane  
located_in axon  
located_in cytoplasmic vesicle membrane  
located_in cytosol  
located_in cytosol  
located_in late endosome  
located_in synapse  
located_in trans-Golgi network  

General protein information

Preferred Names
nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2
Names
NMN adenylyltransferase 2
NMN/NaMN adenylyltransferase 2
naMN adenylyltransferase 1
naMN adenylyltransferase 2
nicotinamide mononucleotide adenylyltransferase 2
nicotinate-nucleotide adenylyltransferase 1
nicotinate-nucleotide adenylyltransferase 2
NP_001041507.1
XP_063128171.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001048042.1NP_001041507.1  nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2

    See identical proteins and their annotated locations for NP_001041507.1

    Status: PROVISIONAL

    Source sequence(s)
    DQ022370
    UniProtKB/Swiss-Prot
    Q0HA29
    UniProtKB/TrEMBL
    F1LPZ7
    Related
    ENSRNOP00000029020.5, ENSRNOT00000038183.7
    Conserved Domains (1) summary
    cd09286
    Location:9302
    NMNAT_Eukarya; Nicotinamide/nicotinate mononucleotide adenylyltransferase, Eukaryotic

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    67655794..67831609
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063272101.1XP_063128171.1  nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2 isoform X1

    UniProtKB/TrEMBL
    F1LPZ7

RNA

  1. XR_010056909.1 RNA Sequence

    Related
    ENSRNOT00000099558.2
External link. Please review our privacy policy.