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    P2ry1 purinergic receptor P2Y1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25265, updated on 9-Dec-2024

    Summary

    Official Symbol
    P2ry1provided by RGD
    Official Full Name
    purinergic receptor P2Y1provided by RGD
    Primary source
    RGD:3242
    See related
    EnsemblRapid:ENSRNOG00000014232 AllianceGenome:RGD:3242
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    P2y; P2y1
    Summary
    Enables several functions, including A1 adenosine receptor binding activity; G protein-coupled purinergic nucleotide receptor activity; and adenyl ribonucleotide binding activity. Involved in several processes, including positive regulation of phosphate metabolic process; purinergic nucleotide receptor signaling pathway; and regulation of secretion by cell. Located in several cellular components, including basolateral plasma membrane; postsynaptic density; and postsynaptic membrane. Is active in glutamatergic synapse and presynaptic active zone membrane. Used to study impotence. Orthologous to human P2RY1 (purinergic receptor P2Y1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 119.4), Spleen (RPKM 41.7) and 8 other tissues See more
    Orthologs
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    Genomic context

    See P2ry1 in Genome Data Viewer
    Location:
    2q31
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (147391661..147397870)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (145241975..145248186)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (151314818..151320312)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene zinc finger, MYND-type containing 8, pseudogene 1 Neighboring gene mitochondrial transcription termination factor 1, pseudogene 3 Neighboring gene serine and arginine rich splicing factor 10, pseudogene 2 Neighboring gene RAP2B, member of RAS oncogene family

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Items 1 - 25 of 42
    Process Evidence Code Pubs
    involved_in G protein-coupled adenosine receptor signaling pathway PubMed 
    involved_in G protein-coupled purinergic nucleotide receptor signaling pathway PubMed 
    involved_in G protein-coupled receptor signaling pathway PubMed 
    involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway PubMed 
    involved_in blood vessel diameter maintenance PubMed 
    acts_upstream_of_or_within cellular response to organic cyclic compound  
    involved_in cellular response to purine-containing compound  
    involved_in cellular response to purine-containing compound  
    involved_in eating behavior PubMed 
    acts_upstream_of establishment of localization in cell  
    involved_in glial cell migration PubMed 
    NOT involved_in microglial cell activation PubMed 
    acts_upstream_of monoatomic ion transport  
    involved_in negative regulation of norepinephrine secretion PubMed 
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway  
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway  
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway  
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway PubMed 
    involved_in platelet activation  
    involved_in positive regulation of ERK1 and ERK2 cascade PubMed 
    involved_in positive regulation of cytosolic calcium ion concentration PubMed 
    involved_in positive regulation of cytosolic calcium ion concentration PubMed 
    involved_in positive regulation of hormone secretion PubMed 
    involved_in positive regulation of inositol trisphosphate biosynthetic process PubMed 
    acts_upstream_of_or_within positive regulation of monoatomic ion transport  
    involved_in positive regulation of penile erection PubMed 
    involved_in positive regulation of protein phosphorylation PubMed 
    involved_in positive regulation of transcription by RNA polymerase II PubMed 
    involved_in protein localization to plasma membrane PubMed 
    involved_in regulation of cell shape  
    involved_in regulation of cell shape  
    involved_in regulation of presynaptic cytosolic calcium ion concentration PubMed 
    involved_in regulation of presynaptic cytosolic calcium ion concentration PubMed 
    involved_in regulation of presynaptic cytosolic calcium ion concentration PubMed 
    involved_in regulation of signaling receptor activity PubMed 
    involved_in regulation of synaptic vesicle exocytosis PubMed 
    involved_in regulation of synaptic vesicle exocytosis PubMed 
    involved_in regulation of synaptic vesicle exocytosis PubMed 
    involved_in relaxation of muscle  
    involved_in response to growth factor PubMed 
    involved_in response to mechanical stimulus PubMed 
    involved_in signal transduction involved in regulation of gene expression PubMed 
    Items 1 - 25 of 42
    Component Evidence Code Pubs
    located_in apical plasma membrane PubMed 
    located_in basolateral plasma membrane PubMed 
    located_in cell body PubMed 
    located_in cilium  
    located_in dendrite PubMed 
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse PubMed 
    is_active_in plasma membrane  
    located_in plasma membrane PubMed 
    located_in plasma membrane  
    located_in plasma membrane  
    located_in postsynaptic density PubMed 
    located_in postsynaptic membrane PubMed 
    is_active_in presynaptic active zone membrane PubMed 

    General protein information

    Preferred Names
    P2Y purinoceptor 1
    Names
    ATP receptor
    P2 purinoreceptor subclass 2Y
    P2Y ATP receptor 1
    purinergic receptor P2Y, G-protein coupled, 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012800.3NP_036932.1  P2Y purinoceptor 1

      See identical proteins and their annotated locations for NP_036932.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      P49651
      UniProtKB/TrEMBL
      A6JVM2
      Related
      ENSRNOP00000019304.3, ENSRNOT00000019305.6
      Conserved Domains (1) summary
      pfam00001
      Location:68324
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      147391661..147397870
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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