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    Lrp2 LDL receptor related protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29216, updated on 9-Dec-2024

    Summary

    Official Symbol
    Lrp2provided by RGD
    Official Full Name
    LDL receptor related protein 2provided by RGD
    Primary source
    RGD:68407
    See related
    EnsemblRapid:ENSRNOG00000056184 AllianceGenome:RGD:68407
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables several functions, including PDZ domain binding activity; insulin-like growth factor I binding activity; and low-density lipoprotein particle receptor binding activity. Involved in several processes, including chemoattraction of axon; positive regulation of transport; and protein transport. Located in several cellular components, including apical plasma membrane; axonal growth cone; and brush border membrane. Part of receptor complex. Used to study hypertension. Biomarker of autosomal dominant polycystic kidney disease; end stage renal disease; membranous glomerulonephritis; and nephrosis. Human ortholog(s) of this gene implicated in Donnai-Barrow syndrome and autoimmune thyroiditis. Orthologous to human LRP2 (LDL receptor related protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 5350.7) See more
    Orthologs
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    Genomic context

    See Lrp2 in Genome Data Viewer
    Location:
    3q21
    Exon count:
    79
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (74597148..74754535, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (54189305..54346769, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (55665153..55822484, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene ATP binding cassette subfamily B member 11 Neighboring gene DNA mismatch repair protein Msh6-like Neighboring gene dehydrogenase/reductase 9 Neighboring gene cofilin 1, pseudogene 10 Neighboring gene uncharacterized LOC108350390

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables PDZ domain binding PubMed 
    enables SH3 domain binding  
    NOT enables amyloid-beta binding  
    enables calcium ion binding  
    enables calcium ion binding  
    enables calcium ion binding  
    enables cargo receptor activity  
    enables hemoglobin binding PubMed 
    enables hormone binding  
    enables hormone binding PubMed 
    enables insulin-like growth factor I binding PubMed 
    enables low-density lipoprotein particle receptor binding PubMed 
    enables nuclear receptor binding PubMed 
    enables protein binding PubMed 
    enables protein transporter activity PubMed 
    enables protein-containing complex binding PubMed 
    enables protein-folding chaperone binding  
    enables protein-folding chaperone binding  
    Items 1 - 25 of 99
    Process Evidence Code Pubs
    involved_in amyloid-beta clearance PubMed 
    involved_in animal organ regeneration PubMed 
    involved_in aorta development  
    acts_upstream_of_or_within aorta development  
    involved_in cell population proliferation  
    acts_upstream_of_or_within cell population proliferation  
    involved_in cellular response to growth factor stimulus PubMed 
    involved_in chemoattraction of axon PubMed 
    involved_in coronary artery morphogenesis  
    involved_in coronary artery morphogenesis  
    involved_in coronary artery morphogenesis  
    acts_upstream_of_or_within coronary vasculature development  
    involved_in cranial skeletal system development  
    acts_upstream_of_or_within cranial skeletal system development  
    involved_in diol metabolic process  
    acts_upstream_of_or_within diol metabolic process  
    involved_in endocytic hemoglobin import into cell PubMed 
    involved_in endocytosis  
    involved_in endocytosis PubMed 
    involved_in endosomal transport PubMed 
    involved_in folate import across plasma membrane  
    involved_in folate import across plasma membrane  
    involved_in folate import across plasma membrane  
    involved_in forebrain development  
    acts_upstream_of_or_within forebrain development  
    involved_in gene expression  
    acts_upstream_of_or_within gene expression  
    acts_upstream_of_or_within heart development  
    involved_in kidney development  
    acts_upstream_of_or_within kidney development  
    involved_in male gonad development  
    involved_in male gonad development  
    involved_in male gonad development  
    involved_in metal ion transport PubMed 
    involved_in metal ion transport  
    involved_in metal ion transport  
    involved_in metanephric proximal tubule development PubMed 
    involved_in negative regulation of BMP signaling pathway  
    involved_in negative regulation of BMP signaling pathway  
    involved_in negative regulation of BMP signaling pathway  
    involved_in negative regulation of apoptotic process  
    acts_upstream_of negative regulation of apoptotic process  
    involved_in negative regulation of endopeptidase activity PubMed 
    involved_in neural tube closure  
    involved_in neural tube closure  
    involved_in neural tube closure  
    involved_in neuron projection arborization  
    involved_in neuron projection arborization  
    involved_in neuron projection arborization  
    acts_upstream_of_or_within outflow tract morphogenesis  
    involved_in outflow tract septum morphogenesis  
    involved_in outflow tract septum morphogenesis  
    involved_in outflow tract septum morphogenesis  
    involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    involved_in positive regulation of endocytosis PubMed 
    involved_in positive regulation of lipoprotein transport PubMed 
    involved_in positive regulation of lysosomal protein catabolic process  
    involved_in positive regulation of neurogenesis  
    involved_in positive regulation of neurogenesis  
    involved_in positive regulation of oligodendrocyte progenitor proliferation  
    involved_in positive regulation of oligodendrocyte progenitor proliferation  
    involved_in positive regulation of oligodendrocyte progenitor proliferation  
    involved_in protein import PubMed 
    involved_in protein transport  
    involved_in protein transport  
    involved_in pulmonary artery morphogenesis  
    involved_in pulmonary artery morphogenesis  
    involved_in pulmonary artery morphogenesis  
    involved_in receptor-mediated endocytosis  
    involved_in receptor-mediated endocytosis PubMed 
    involved_in receptor-mediated endocytosis  
    involved_in receptor-mediated endocytosis PubMed 
    acts_upstream_of_or_within receptor-mediated endocytosis  
    involved_in receptor-mediated endocytosis  
    involved_in response to X-ray PubMed 
    involved_in response to leptin  
    involved_in response to leptin PubMed 
    involved_in response to leptin  
    involved_in response to retinoic acid PubMed 
    involved_in response to vitamin D PubMed 
    involved_in response to xenobiotic stimulus PubMed 
    involved_in secondary heart field specification  
    involved_in secondary heart field specification  
    involved_in secondary heart field specification  
    involved_in sensory perception of sound  
    involved_in sensory perception of sound  
    involved_in sensory perception of sound  
    involved_in transcytosis PubMed 
    involved_in vagina development  
    involved_in vagina development  
    involved_in vagina development  
    involved_in ventricular compact myocardium morphogenesis  
    involved_in ventricular compact myocardium morphogenesis  
    involved_in ventricular compact myocardium morphogenesis  
    involved_in ventricular septum development  
    acts_upstream_of_or_within ventricular septum development  
    involved_in vitamin D metabolic process  
    acts_upstream_of_or_within vitamin D metabolic process  
    Items 1 - 25 of 99
    Items 1 - 20 of 44
    Component Evidence Code Pubs
    located_in Golgi apparatus  
    located_in Golgi apparatus  
    located_in apical part of cell  
    is_active_in apical plasma membrane  
    located_in apical plasma membrane PubMed 
    located_in apical plasma membrane  
    located_in apical plasma membrane  
    located_in axon  
    located_in axon  
    located_in axon  
    located_in axonal growth cone PubMed 
    located_in brush border PubMed 
    located_in brush border  
    located_in brush border membrane PubMed 
    located_in brush border membrane  
    located_in brush border membrane  
    located_in cell surface PubMed 
    located_in clathrin-coated pit  
    located_in clathrin-coated pit  
    located_in dendrite  
    located_in dendrite  
    located_in dendrite  
    located_in endocytic vesicle  
    located_in endocytic vesicle  
    located_in endoplasmic reticulum  
    located_in endoplasmic reticulum  
    located_in endosome PubMed 
    located_in endosome  
    located_in endosome  
    located_in endosome lumen  
    located_in external side of plasma membrane  
    located_in external side of plasma membrane  
    located_in external side of plasma membrane  
    located_in extracellular space PubMed 
    located_in membrane  
    located_in membrane  
    is_active_in plasma membrane  
    located_in plasma membrane PubMed 
    located_in plasma membrane  
    part_of protein-containing complex PubMed 
    part_of receptor complex  
    part_of receptor complex PubMed 
    part_of receptor complex  
    part_of receptor complex  
    Items 1 - 20 of 44

    General protein information

    Preferred Names
    low-density lipoprotein receptor-related protein 2
    Names
    LRP-2
    glycoprotein 330
    gp330
    low density lipoprotein-related protein 2
    megalin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_030827.2NP_110454.2  low-density lipoprotein receptor-related protein 2 precursor

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      P98158
      UniProtKB/TrEMBL
      A0A0G2K9W7, A6HM07
      Related
      ENSRNOP00000075159.1, ENSRNOT00000082624.3
      Conserved Domains (11) summary
      smart00192
      Location:29072939
      LDLa; Low-density lipoprotein receptor domain class A
      smart00135
      Location:15021544
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00179
      Location:13911430
      EGF_CA; Calcium-binding EGF-like domain
      COG3391
      Location:21102302
      YncE; DNA-binding beta-propeller fold protein YncE [General function prediction only]
      cd00112
      Location:37613795
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam00057
      Location:10651101
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam00058
      Location:18841928
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      pfam12662
      Location:31343157
      cEGF; Complement Clr-like EGF-like
      pfam14670
      Location:20232059
      FXa_inhibition; Coagulation Factor Xa inhibitory site
      NF033759
      Location:27433131
      exchanger_TraA; outer membrane exchange protein TraA
      cl39070
      Location:837877
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      74597148..74754535 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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