U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Tdg thymine-DNA glycosylase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 114521, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tdgprovided by RGD
    Official Full Name
    thymine-DNA glycosylaseprovided by RGD
    Primary source
    RGD:620959
    See related
    EnsemblRapid:ENSRNOG00000027124 AllianceGenome:RGD:620959
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables DNA-binding transcription factor binding activity and protein domain specific binding activity. Involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in PML body and plasma membrane. Predicted to be active in nucleus. Orthologous to human TDG (thymine DNA glycosylase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 281.5), Spleen (RPKM 162.2) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Tdg in Genome Data Viewer
    Location:
    7q13
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (22965388..22990311, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (21077853..21097617, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (27194000..27213676, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene nuclear transcription factor Y subunit beta Neighboring gene host cell factor C2 Neighboring gene glycosyltransferase 8 domain containing 2 Neighboring gene ubiquinol-cytochrome c reductase complex assembly factor 6 Neighboring gene heat shock protein 90 beta family member 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding  
    enables DNA N-glycosylase activity  
    enables DNA binding  
    enables DNA-binding transcription factor binding PubMed 
    enables G/U mismatch-specific uracil-DNA glycosylase activity  
    enables SUMO binding  
    enables chloride ion binding  
    enables double-stranded DNA binding  
    enables magnesium ion binding  
    enables mismatched DNA binding  
    enables nucleic acid binding  
    enables protein domain specific binding PubMed 
    enables protein kinase C binding  
    enables pyrimidine-specific mismatch base pair DNA N-glycosylase activity  
    enables pyrimidine-specific mismatch base pair DNA N-glycosylase activity  
    enables sodium ion binding  
    enables transcription coregulator activity  
    enables uracil DNA N-glycosylase activity  
    enables uracil DNA N-glycosylase activity  
    Component Evidence Code Pubs
    located_in PML body  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus  
    located_in plasma membrane  
    located_in plasma membrane  

    General protein information

    Preferred Names
    G/T mismatch-specific thymine DNA glycosylase
    NP_001375432.1
    NP_446181.2
    XP_038934169.1
    XP_038934170.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001388503.1NP_001375432.1  G/T mismatch-specific thymine DNA glycosylase isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A0A096MIY3, A0A096MK32
      Related
      ENSRNOP00000067921.1, ENSRNOT00000077041.4
      Conserved Domains (2) summary
      TIGR00584
      Location:2325
      mug; mismatch-specific thymine-DNA glycosylate (mug)
      cd10028
      Location:134138
      UDG-F2_TDG_MUG; motif A [structural motif]
    2. NM_053729.2NP_446181.2  G/T mismatch-specific thymine DNA glycosylase isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A6IFI8, Q99NG8
      Related
      ENSRNOP00000068361.2, ENSRNOT00000076468.4
      Conserved Domains (2) summary
      TIGR00584
      Location:1301
      mug; mismatch-specific thymine-DNA glycosylate (mug)
      cd10028
      Location:110114
      UDG-F2_TDG_MUG; motif A [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      22965388..22990311 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039078241.2XP_038934169.1  G/T mismatch-specific thymine DNA glycosylase isoform X1

      UniProtKB/TrEMBL
      A0A096MK32
      Conserved Domains (2) summary
      TIGR00584
      Location:2325
      mug; mismatch-specific thymine-DNA glycosylate (mug)
      cd10028
      Location:134138
      UDG-F2_TDG_MUG; motif A [structural motif]
    2. XM_039078242.2XP_038934170.1  G/T mismatch-specific thymine DNA glycosylase isoform X2

      UniProtKB/TrEMBL
      A1L1J2, Q99NG8
      Conserved Domains (2) summary
      TIGR00584
      Location:1301
      mug; mismatch-specific thymine-DNA glycosylate (mug)
      cd10028
      Location:110114
      UDG-F2_TDG_MUG; motif A [structural motif]
    External link. Please review our privacy policy.