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Ppp3r1 protein phosphatase 3, regulatory subunit B, alpha [ Rattus norvegicus (Norway rat) ]

Gene ID: 29748, updated on 9-Dec-2024

Summary

Official Symbol
Ppp3r1provided by RGD
Official Full Name
protein phosphatase 3, regulatory subunit B, alphaprovided by RGD
Primary source
RGD:69230
See related
EnsemblRapid:ENSRNOG00000065686 AllianceGenome:RGD:69230
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables phosphoprotein phosphatase activity. Involved in protein dephosphorylation. Predicted to be located in postsynapse and sarcolemma. Predicted to be part of calcineurin complex. Predicted to be active in several cellular components, including Schaffer collateral - CA1 synapse; hippocampal mossy fiber to CA3 synapse; and parallel fiber to Purkinje cell synapse. Biomarker of traumatic brain injury. Human ortholog(s) of this gene implicated in Alzheimer's disease and dilated cardiomyopathy. Orthologous to human PPP3R1 (protein phosphatase 3 regulatory subunit B, alpha). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Brain (RPKM 361.5), Muscle (RPKM 249.0) and 9 other tissues See more
Orthologs
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Genomic context

See Ppp3r1 in Genome Data Viewer
Location:
14q22
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (95758333..95808015)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (91556743..91606391)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (100311224..100360879)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481790 Neighboring gene pleckstrin Neighboring gene uncharacterized LOC120096673 Neighboring gene cannabinoid receptor interacting protein 1 Neighboring gene uncharacterized LOC134481791 Neighboring gene dynein axonemal assembly factor 10 Neighboring gene partner of NOB1 homolog

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium ion binding  
enables calcium-dependent protein serine/threonine phosphatase regulator activity  
enables enzyme binding  
enables phosphatase binding  
enables phosphatase binding  
enables phosphoprotein phosphatase activity PubMed 
enables phosphoprotein phosphatase activity  
enables protein binding PubMed 
enables protein domain specific binding  
Process Evidence Code Pubs
acts_upstream_of_or_within Schwann cell development  
acts_upstream_of_or_within branching involved in blood vessel morphogenesis  
involved_in calcineurin-NFAT signaling cascade  
acts_upstream_of_or_within calcineurin-NFAT signaling cascade  
involved_in calcineurin-NFAT signaling cascade  
acts_upstream_of_or_within epithelial to mesenchymal transition  
acts_upstream_of_or_within heart development  
acts_upstream_of_or_within lung epithelial cell differentiation  
acts_upstream_of_or_within myelination in peripheral nervous system  
involved_in positive regulation of transcription by RNA polymerase II  
involved_in postsynaptic modulation of chemical synaptic transmission  
involved_in protein dephosphorylation PubMed 
acts_upstream_of_or_within protein dephosphorylation  
acts_upstream_of_or_within protein import into nucleus  
acts_upstream_of_or_within protein localization to nucleus  
involved_in regulation of postsynaptic neurotransmitter receptor internalization  
involved_in regulation of synaptic vesicle cycle  
Component Evidence Code Pubs
is_active_in Schaffer collateral - CA1 synapse  
part_of calcineurin complex  
part_of calcineurin complex  
located_in cytosol  
is_active_in glutamatergic synapse  
is_active_in hippocampal mossy fiber to CA3 synapse  
is_active_in parallel fiber to Purkinje cell synapse  
located_in sarcolemma  
is_active_in synapse  

General protein information

Preferred Names
calcineurin subunit B type 1
Names
protein phosphatase 2B regulatory subunit 1
NP_059005.1
XP_006251579.3
XP_063129082.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017309.3NP_059005.1  calcineurin subunit B type 1

    See identical proteins and their annotated locations for NP_059005.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014
    UniProtKB/Swiss-Prot
    P63100
    UniProtKB/TrEMBL
    A6JPY9
    Related
    ENSRNOP00000111194.1, ENSRNOT00000158230.1
    Conserved Domains (1) summary
    COG5126
    Location:13157
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    95758333..95808015
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006251517.5XP_006251579.3  calcineurin subunit B type 1 isoform X1

    UniProtKB/Swiss-Prot
    P63100
    Related
    ENSRNOP00000037143.6, ENSRNOT00000031275.8
    Conserved Domains (2) summary
    PTZ00184
    Location:64200
    PTZ00184; calmodulin; Provisional
    cd00051
    Location:137203
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
  2. XM_063273012.1XP_063129082.1  calcineurin subunit B type 1 isoform X2

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