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Adam19 ADAM metallopeptidase domain 19 [ Rattus norvegicus (Norway rat) ]

Gene ID: 303068, updated on 9-Dec-2024

Summary

Official Symbol
Adam19provided by RGD
Official Full Name
ADAM metallopeptidase domain 19provided by RGD
Primary source
RGD:1585017
See related
EnsemblRapid:ENSRNOG00000042980 AllianceGenome:RGD:1585017
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Sox30
Summary
Predicted to enable SH3 domain binding activity and metalloendopeptidase activity involved in amyloid precursor protein catabolic process. Predicted to be involved in several processes, including amyloid precursor protein catabolic process; membrane protein ectodomain proteolysis; and positive regulation of cell-cell adhesion mediated by cadherin. Predicted to act upstream of or within heart development. Predicted to be located in Golgi apparatus and nucleus. Orthologous to human ADAM19 (ADAM metallopeptidase domain 19). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Heart (RPKM 306.1), Thymus (RPKM 156.4) and 7 other tissues See more
Orthologs
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Genomic context

See Adam19 in Genome Data Viewer
Location:
10q21
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (30992713..31084455)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (30491362..30583115)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (31146107..31240582)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene activated RNA polymerase II transcriptional coactivator p15 pseudogene Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC120095083 Neighboring gene NIPA-like domain containing 4 Neighboring gene uncharacterized LOC134480683 Neighboring gene cytoplasmic FMR1 interacting protein 2

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Related articles in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Gene Ontology Provided by RGD

Component Evidence Code Pubs
located_in Golgi apparatus  
NOT located_in external side of plasma membrane  
located_in nucleus  

General protein information

Preferred Names
disintegrin and metalloproteinase domain-containing protein 19
Names
SRY-box containing gene 30
a disintegrin and metallopeptidase domain 19 (meltrin beta)
a disintegrin and metalloproteinase domain 19 (meltrin beta)
meltrin beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001160228.1NP_001153700.1  disintegrin and metalloproteinase domain-containing protein 19 precursor

    See identical proteins and their annotated locations for NP_001153700.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A0A8I5Y236, A6HDQ9, D3ZPM7
    Related
    ENSRNOP00000008184.6, ENSRNOT00000008184.8
    Conserved Domains (5) summary
    smart00050
    Location:440500
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:502650
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:211407
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam01421
    Location:211409
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:62162
    Pep_M12B_propep; Reprolysin family propeptide

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    30992713..31084455
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063268971.1XP_063125041.1  disintegrin and metalloproteinase domain-containing protein 19 isoform X2

  2. XM_039085916.2XP_038941844.1  disintegrin and metalloproteinase domain-containing protein 19 isoform X3

    Conserved Domains (3) summary
    pfam01421
    Location:211409
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:45163
    Pep_M12B_propep; Reprolysin family propeptide
    cl10507
    Location:440460
    Disintegrin
  3. XM_039085915.2XP_038941843.1  disintegrin and metalloproteinase domain-containing protein 19 isoform X1

    UniProtKB/TrEMBL
    D3ZPM7
    Conserved Domains (4) summary
    smart00050
    Location:386446
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:448596
    ACR; ADAM Cysteine-Rich Domain
    pfam01421
    Location:157355
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:15109
    Pep_M12B_propep; Reprolysin family propeptide
  4. XM_039085917.2XP_038941845.1  disintegrin and metalloproteinase domain-containing protein 19 isoform X4

    Conserved Domains (2) summary
    smart00608
    Location:34182
    ACR; ADAM Cysteine-Rich Domain
    cl10507
    Location:132
    Disintegrin
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