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Cfp complement factor properdin [ Rattus norvegicus (Norway rat) ]

Gene ID: 299314, updated on 9-Dec-2024

Summary

Official Symbol
Cfpprovided by RGD
Official Full Name
complement factor properdinprovided by RGD
Primary source
RGD:1594557
See related
EnsemblRapid:ENSRNOG00000025811 AllianceGenome:RGD:1594557
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Pfc
Summary
Predicted to be involved in complement activation, alternative pathway. Predicted to be located in cytoplasmic side of Golgi membrane; extracellular space; and secretory granule. Human ortholog(s) of this gene implicated in X-linked properdin deficiency. Orthologous to human CFP (complement factor properdin). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Spleen (RPKM 1392.2), Liver (RPKM 224.7) and 3 other tissues See more
Orthologs
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Genomic context

See Cfp in Genome Data Viewer
Location:
Xq11
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (3715551..3721113)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (1162014..1167576)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (1311121..1316683)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein 81 Neighboring gene ubiquitously-expressed, prefoldin-like chaperone Neighboring gene ETS transcription factor ELK1 Neighboring gene synapsin I Neighboring gene 60S ribosomal protein L12-like Neighboring gene TIMP metallopeptidase inhibitor 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Gene Ontology Provided by RGD

Component Evidence Code Pubs
located_in cytoplasmic side of Golgi membrane  
located_in extracellular space  
located_in secretory granule  

General protein information

Preferred Names
properdin
Names
Properdin P factor, complement
properdin factor, complement

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106757.2NP_001100227.1  properdin precursor

    See identical proteins and their annotated locations for NP_001100227.1

    Status: PROVISIONAL

    Source sequence(s)
    BC158889
    UniProtKB/TrEMBL
    A6JZQ8, B0BNN4, F7EX91
    Related
    ENSRNOP00000031039.5, ENSRNOT00000038909.8
    Conserved Domains (2) summary
    smart00209
    Location:192251
    TSP1; Thrombospondin type 1 repeats
    pfam00090
    Location:136184
    TSP_1; Thrombospondin type 1 domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    3715551..3721113
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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