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Nedd9 neural precursor cell expressed, developmentally down-regulated 9 [ Rattus norvegicus (Norway rat) ]

Gene ID: 291044, updated on 9-Dec-2024

Summary

Official Symbol
Nedd9provided by RGD
Official Full Name
neural precursor cell expressed, developmentally down-regulated 9provided by RGD
Primary source
RGD:1306276
See related
EnsemblRapid:ENSRNOG00000014548 AllianceGenome:RGD:1306276
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable protein tyrosine kinase binding activity. Predicted to be involved in several processes, including positive regulation of dendritic spine maintenance; positive regulation of immunological synapse formation; and regulation of cell migration. Predicted to act upstream of or within activation of GTPase activity. Predicted to be located in several cellular components, including basolateral plasma membrane; focal adhesion; and microtubule cytoskeleton. Predicted to be active in cytoplasm. Predicted to colocalize with plasma membrane. Orthologous to human NEDD9 (neural precursor cell expressed, developmentally down-regulated 9). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Lung (RPKM 451.0), Spleen (RPKM 243.1) and 9 other tissues See more
Orthologs
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Genomic context

See Nedd9 in Genome Data Viewer
Location:
17p12
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (23495531..23673780)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (23289793..23468026)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (22984792..23179701)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 170B Neighboring gene uncharacterized LOC134482837 Neighboring gene uncharacterized LOC134482836 Neighboring gene uncharacterized LOC102548345 Neighboring gene small integral membrane protein 13 Neighboring gene small integral membrane protein 13 like Neighboring gene microRNA 3566

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Gene Ontology Provided by RGD

Process Evidence Code Pubs
acts_upstream_of_or_within activation of GTPase activity  
involved_in cell adhesion  
involved_in cell migration  
involved_in cell surface receptor protein tyrosine kinase signaling pathway  
involved_in cilium disassembly  
involved_in learning or memory  
involved_in lymphocyte migration into lymphoid organs  
involved_in negative regulation of cell migration  
involved_in positive regulation of cell migration  
involved_in positive regulation of dendritic spine maintenance  
involved_in positive regulation of immunological synapse formation  
involved_in positive regulation of lymphocyte chemotaxis  
involved_in positive regulation of osteoclast differentiation  
involved_in positive regulation of protein localization  
involved_in positive regulation of protein tyrosine kinase activity  
involved_in positive regulation of substrate adhesion-dependent cell spreading  
involved_in regulation of actin cytoskeleton organization  
Component Evidence Code Pubs
located_in basolateral plasma membrane  
located_in ciliary basal body  
is_active_in cytoplasm  
located_in cytosol  
located_in cytosol  
located_in focal adhesion  
located_in immunological synapse  
located_in mitotic spindle  
located_in nucleoplasm  
located_in nucleoplasm  
located_in nucleus  
colocalizes_with plasma membrane  
located_in plasma membrane  
located_in spindle pole  

General protein information

Preferred Names
enhancer of filamentation 1
Names
neural precursor cell expressed, developmentally down-regulated gene 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001011922.3NP_001011922.1  enhancer of filamentation 1

    See identical proteins and their annotated locations for NP_001011922.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000017
    UniProtKB/TrEMBL
    A6J767, F7F3Z5, Q5U2Y4
    Related
    ENSRNOP00000112768.1, ENSRNOT00000174126.1
    Conserved Domains (3) summary
    cd12002
    Location:763
    SH3_NEDD9; Src homology 3 domain of CAS (Crk-Associated Substrate) scaffolding protein family member, Neural precursor cell Expressed, Developmentally Down-regulated 9
    pfam12026
    Location:620827
    DUF3513; Domain of unknown function (DUF3513)
    cl07433
    Location:400561
    Serine_rich_CAS; Serine rich Four helix bundle domain of CAS (Crk-Associated Substrate) scaffolding proteins; a protein interaction module

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    23495531..23673780
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006253786.5XP_006253848.1  enhancer of filamentation 1 isoform X1

    See identical proteins and their annotated locations for XP_006253848.1

    UniProtKB/TrEMBL
    A0A0G2JZL7, A6J766
    Related
    ENSRNOP00000071096.2, ENSRNOT00000078310.3
    Conserved Domains (3) summary
    cd12002
    Location:763
    SH3_NEDD9; Src homology 3 domain of CAS (Crk-Associated Substrate) scaffolding protein family member, Neural precursor cell Expressed, Developmentally Down-regulated 9
    pfam12026
    Location:620827
    DUF3513; Domain of unknown function (DUF3513)
    cl07433
    Location:400561
    Serine_rich_CAS; Serine rich Four helix bundle domain of CAS (Crk-Associated Substrate) scaffolding proteins; a protein interaction module
  2. XM_039095477.2XP_038951405.1  enhancer of filamentation 1 isoform X2

    Related
    ENSRNOP00000060831.2, ENSRNOT00000067374.4
    Conserved Domains (3) summary
    cd12002
    Location:157
    SH3_NEDD9; Src homology 3 domain of CAS (Crk-Associated Substrate) scaffolding protein family member, Neural precursor cell Expressed, Developmentally Down-regulated 9
    pfam12026
    Location:614821
    DUF3513; Domain of unknown function (DUF3513)
    cl07433
    Location:394555
    Serine_rich_CAS; Serine rich Four helix bundle domain of CAS (Crk-Associated Substrate) scaffolding proteins; a protein interaction module
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