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    Slc25a18 solute carrier family 25 member 18 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 681896, updated on 9-Dec-2024

    Summary

    Official Symbol
    Slc25a18provided by RGD
    Official Full Name
    solute carrier family 25 member 18provided by RGD
    Primary source
    RGD:1590470
    See related
    EnsemblRapid:ENSRNOG00000042731 AllianceGenome:RGD:1590470
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable L-aspartate transmembrane transporter activity; L-glutamate transmembrane transporter activity; and amino acid:proton symporter activity. Predicted to be involved in L-glutamate transmembrane transport; aspartate transmembrane transport; and malate-aspartate shuttle. Located in mitochondrial inner membrane. Orthologous to human SLC25A18 (solute carrier family 25 member 18). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 124.1), Testes (RPKM 16.3) and 2 other tissues See more
    Orthologs
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    Genomic context

    See Slc25a18 in Genome Data Viewer
    Location:
    4q42
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (155672939..155693549)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (154000808..154021373)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (153330069..153350447)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108350753 Neighboring gene CECR2, histone acetyl-lysine reader Neighboring gene ATPase H+ transporting V1 subunit E1 Neighboring gene Bcl2-like 13

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • MGC105602

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables L-aspartate transmembrane transporter activity  
    enables L-glutamate transmembrane transporter activity  
    enables amino acid:proton symporter activity  
    enables amino acid:proton symporter activity  
    enables amino acid:proton symporter activity  
    Process Evidence Code Pubs
    involved_in L-aspartate transmembrane transport  
    involved_in L-glutamate transmembrane transport  
    involved_in L-glutamate transmembrane transport  
    involved_in L-glutamate transmembrane transport  
    involved_in L-glutamate transmembrane transport  
    involved_in aspartate transmembrane transport  
    involved_in malate-aspartate shuttle  
    involved_in proton transmembrane transport  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane PubMed 
    located_in mitochondrial inner membrane  
    located_in mitochondrial inner membrane  
    located_in mitochondrion PubMed 

    General protein information

    Preferred Names
    mitochondrial glutamate carrier 2
    Names
    GC-2
    glutamate carrier 2, mitochondrial
    glutamate/H(+) symporter 2
    solute carrier family 25 (glutamate carrier), member 18
    solute carrier family 25 (mitochondrial carrier), member 18

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001044280.2NP_001037745.2  mitochondrial glutamate carrier 2

      See identical proteins and their annotated locations for NP_001037745.2

      Status: VALIDATED

      Source sequence(s)
      BC094517, BG380364, CB726923
      UniProtKB/Swiss-Prot
      Q505J6
      UniProtKB/TrEMBL
      A0A8I5ZRK2, A6ILB0
      Related
      ENSRNOP00000015561.4, ENSRNOT00000015560.9
      Conserved Domains (1) summary
      pfam00153
      Location:9102
      Mito_carr; Mitochondrial carrier protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      155672939..155693549
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039108348.2XP_038964276.1  mitochondrial glutamate carrier 2 isoform X3

      Conserved Domains (1) summary
      pfam00153
      Location:124209
      Mito_carr; Mitochondrial carrier protein
    2. XM_063286684.1XP_063142754.1  mitochondrial glutamate carrier 2 isoform X1

      UniProtKB/Swiss-Prot
      Q505J6
      UniProtKB/TrEMBL
      A0A8I5ZRK2, A6ILB0
    3. XM_039108347.1XP_038964275.1  mitochondrial glutamate carrier 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZRK2
      Related
      ENSRNOP00000081133.1, ENSRNOT00000113398.2
      Conserved Domains (1) summary
      pfam00153
      Location:176261
      Mito_carr; Mitochondrial carrier protein
    4. XM_063286685.1XP_063142755.1  mitochondrial glutamate carrier 2 isoform X3

    5. XM_063286686.1XP_063142756.1  mitochondrial glutamate carrier 2 isoform X4

    RNA

    1. XR_010065706.1 RNA Sequence

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