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Tlcd1 TLC domain containing 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 287472, updated on 9-Dec-2024

Summary

Official Symbol
Tlcd1provided by RGD
Official Full Name
TLC domain containing 1provided by RGD
Primary source
RGD:1359195
See related
EnsemblRapid:ENSRNOG00000071015 AllianceGenome:RGD:1359195
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in several processes, including membrane assembly; phospholipid homeostasis; and regulation of membrane lipid distribution. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human TLCD1 (TLC domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Kidney (RPKM 124.2), Brain (RPKM 47.6) and 9 other tissues See more
Orthologs
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Genomic context

See Tlcd1 in Genome Data Viewer
Location:
10q25
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (63572541..63574574)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (63074469..63076502)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (65439104..65441140)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene Tnf receptor associated factor 4 Neighboring gene NIMA-related kinase 8 Neighboring gene small nucleolar RNA, C/D box 42A Neighboring gene ribosomal protein L23A Neighboring gene small nucleolar RNA, C/D box 4A

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in membrane assembly  
involved_in membrane assembly  
involved_in phospholipid homeostasis  
involved_in phospholipid homeostasis  
involved_in plasma membrane organization  
involved_in plasma membrane organization  
involved_in regulation of membrane lipid distribution  
involved_in regulation of membrane lipid distribution  
Component Evidence Code Pubs
located_in membrane  
is_active_in plasma membrane  
located_in plasma membrane  

General protein information

Preferred Names
TLC domain-containing protein 1
Names
calfacilitin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013858.1NP_001013880.1  TLC domain-containing protein 1 precursor

    See identical proteins and their annotated locations for NP_001013880.1

    Status: PROVISIONAL

    Source sequence(s)
    BC085876
    UniProtKB/Swiss-Prot
    Q5U2T1
    UniProtKB/TrEMBL
    A0A8I6A667, A6HH14
    Related
    ENSRNOP00000084592.1, ENSRNOT00000098225.2
    Conserved Domains (1) summary
    smart00724
    Location:41234
    TLC; TRAM, LAG1 and CLN8 homology domains

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    63572541..63574574
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008767957.3XP_008766179.1  TLC domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_008766179.1

    UniProtKB/TrEMBL
    A6HH15
    Conserved Domains (1) summary
    smart00724
    Location:14163
    TLC; TRAM, LAG1 and CLN8 homology domains
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