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    Gabarap GABA type A receptor-associated protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 58974, updated on 9-Dec-2024

    Summary

    Official Symbol
    Gabarapprovided by RGD
    Official Full Name
    GABA type A receptor-associated proteinprovided by RGD
    Primary source
    RGD:61911
    See related
    AllianceGenome:RGD:61911
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables GABA receptor binding activity. Predicted to be involved in several processes, including macroautophagy; positive regulation of protein metabolic process; and regulation of neurotransmitter receptor localization to postsynaptic specialization membrane. Predicted to act upstream of or within microtubule cytoskeleton organization. Located in cell body and perinuclear region of cytoplasm. Is active in GABA-ergic synapse and postsynaptic specialization, intracellular component. Orthologous to human GABARAP (GABA type A receptor-associated protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 1314.7), Testes (RPKM 947.4) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Gabarap in Genome Data Viewer
    Location:
    10q24
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (55213465..55216787)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (54714777..54718099)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (56601288..56604223)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene elongator acetyltransferase complex subunit 5 Neighboring gene CTD nuclear envelope phosphatase 1 Neighboring gene PHD finger protein 23 Neighboring gene dishevelled segment polarity protein 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GABA receptor binding  
    enables GABA receptor binding  
    enables GABA receptor binding PubMed 
    enables GABA receptor binding  
    enables beta-tubulin binding  
    enables beta-tubulin binding  
    enables microtubule binding  
    enables phosphatidylethanolamine binding  
    enables phosphatidylethanolamine binding  
    enables phosphatidylethanolamine binding  
    enables protein binding PubMed 
    enables ubiquitin protein ligase binding  
    enables ubiquitin protein ligase binding  
    enables ubiquitin protein ligase binding  
    Process Evidence Code Pubs
    involved_in apoptotic process  
    involved_in autophagosome assembly  
    involved_in autophagosome maturation  
    involved_in autophagy  
    involved_in cellular response to nitrogen starvation  
    involved_in extrinsic apoptotic signaling pathway via death domain receptors  
    involved_in extrinsic apoptotic signaling pathway via death domain receptors  
    involved_in extrinsic apoptotic signaling pathway via death domain receptors  
    acts_upstream_of_or_within microtubule cytoskeleton organization  
    involved_in mitophagy  
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process  
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process  
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process  
    involved_in positive regulation of protein K48-linked ubiquitination  
    involved_in positive regulation of protein K48-linked ubiquitination  
    involved_in positive regulation of protein K48-linked ubiquitination  
    involved_in protein transport  
    involved_in regulation of Rac protein signal transduction  
    involved_in regulation of Rac protein signal transduction  
    involved_in regulation of Rac protein signal transduction  
    involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane  
    Items 1 - 20 of 23
    Component Evidence Code Pubs
    is_active_in GABA-ergic synapse PubMed 
    is_active_in GABA-ergic synapse  
    located_in Golgi apparatus  
    located_in Golgi membrane  
    located_in actin cytoskeleton  
    located_in autophagosome  
    located_in autophagosome  
    located_in autophagosome  
    is_active_in autophagosome membrane  
    located_in autophagosome membrane  
    located_in autophagosome membrane  
    located_in axoneme  
    located_in axoneme  
    located_in cell body PubMed 
    located_in cytoplasmic vesicle  
    located_in lysosome  
    located_in microtubule  
    part_of microtubule associated complex  
    located_in perinuclear region of cytoplasm PubMed 
    located_in plasma membrane  
    is_active_in postsynaptic specialization, intracellular component PubMed 
    located_in smooth endoplasmic reticulum  
    located_in sperm midpiece  
    Items 1 - 20 of 23

    General protein information

    Preferred Names
    gamma-aminobutyric acid receptor-associated protein
    Names
    GABA(A) receptor-associated protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172036.4NP_742033.1  gamma-aminobutyric acid receptor-associated protein

      See identical proteins and their annotated locations for NP_742033.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      P60517
      UniProtKB/TrEMBL
      A6HFZ8
      Conserved Domains (1) summary
      cd17232
      Location:2116
      Ubl_ATG8_GABARAP; ubiquitin-like (Ubl) domain found in gamma-aminobutyric acid receptor-associated protein (GABARAP)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      55213465..55216787
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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