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Klhl40 kelch-like family member 40 [ Rattus norvegicus (Norway rat) ]

Gene ID: 316088, updated on 9-Dec-2024

Summary

Official Symbol
Klhl40provided by RGD
Official Full Name
kelch-like family member 40provided by RGD
Primary source
RGD:1305368
See related
EnsemblRapid:ENSRNOG00000019390 AllianceGenome:RGD:1305368
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Kbtbd5
Summary
Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process; regulation of protein metabolic process; and skeletal muscle fiber development. Predicted to act upstream of or within skeletal muscle fiber differentiation. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in A band and I band. Human ortholog(s) of this gene implicated in nemaline myopathy 8. Orthologous to human KLHL40 (kelch like family member 40). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Muscle (RPKM 378.2), Adrenal (RPKM 53.3) and 1 other tissue See more
Orthologs
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Genomic context

See Klhl40 in Genome Data Viewer
Location:
8q32
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (130318793..130324309)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (121441285..121446801)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (130416265..130421871)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene natural killer cell triggering receptor Neighboring gene zinc finger and BTB domain containing 47 Neighboring gene hedgehog acyltransferase-like Neighboring gene coiled-coil domain containing 13 Neighboring gene HIG1 hypoxia inducible domain family, member 1A

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process  
acts_upstream_of_or_within negative regulation of proteasomal ubiquitin-dependent protein catabolic process  
involved_in negative regulation of protein ubiquitination  
acts_upstream_of_or_within negative regulation of protein ubiquitination  
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process  
involved_in positive regulation of protein ubiquitination  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process  
acts_upstream_of proteasome-mediated ubiquitin-dependent protein catabolic process  
acts_upstream_of protein ubiquitination  
involved_in skeletal muscle fiber development  
acts_upstream_of_or_within skeletal muscle fiber development  
involved_in skeletal muscle fiber development  
acts_upstream_of_or_within skeletal muscle fiber differentiation  
involved_in skeletal muscle fiber differentiation  
Component Evidence Code Pubs
is_active_in A band  
located_in A band  
part_of Cul3-RING ubiquitin ligase complex  
part_of Cul3-RING ubiquitin ligase complex  
is_active_in I band  
located_in I band  
is_active_in cytoplasm  
located_in cytoplasm  

General protein information

Preferred Names
kelch-like protein 40
Names
kelch repeat and BTB (POZ) domain containing 5
kelch repeat and BTB domain-containing protein 5
kelch-like 40

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108195.2NP_001101665.2  kelch-like protein 40

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    A6I459, D4AA43
    Related
    ENSRNOP00000026234.6, ENSRNOT00000026234.7
    Conserved Domains (3) summary
    PHA03098
    Location:47594
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:402448
    Kelch; KELCH repeat [structural motif]
    cl38908
    Location:6137
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    130318793..130324309
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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