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Ncf2 neutrophil cytosolic factor 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 364018, updated on 9-Dec-2024

Summary

Official Symbol
Ncf2provided by RGD
Official Full Name
neutrophil cytosolic factor 2provided by RGD
Primary source
RGD:1309424
See related
EnsemblRapid:ENSRNOG00000028016 AllianceGenome:RGD:1309424
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
NCF-2; p67phox
Summary
Predicted to enable small GTPase binding activity and superoxide-generating NADPH oxidase activator activity. Predicted to contribute to superoxide-generating NAD(P)H oxidase activity. Involved in several processes, including response to hyperoxia; response to laminar fluid shear stress; and response to progesterone. Predicted to be located in acrosomal vesicle; cytosol; and membrane. Predicted to be part of NADPH oxidase complex. Used to study proteinuria; renal fibrosis; and visual epilepsy. Biomarker of hypertension and obesity. Human ortholog(s) of this gene implicated in Alzheimer's disease; autosomal recessive chronic granulomatous disease 2; and rheumatoid arthritis. Orthologous to human NCF2 (neutrophil cytosolic factor 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Spleen (RPKM 78.3), Lung (RPKM 54.4) and 9 other tissues See more
Orthologs
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Genomic context

See Ncf2 in Genome Data Viewer
Location:
13q21
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (67505492..67536015)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (64955622..64986144)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (70226441..70259019)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481515 Neighboring gene ribosomal protein L15, pseudogene 10 Neighboring gene SMG7 nonsense mediated mRNA decay factor Neighboring gene uncharacterized LOC134481570

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in cellular response to hormone stimulus PubMed 
involved_in phagocytosis  
involved_in positive regulation of blood pressure PubMed 
involved_in positive regulation of neuron apoptotic process PubMed 
involved_in regulation of reactive oxygen species biosynthetic process PubMed 
involved_in respiratory burst  
involved_in response to activity PubMed 
involved_in response to glucose PubMed 
involved_in response to hyperoxia PubMed 
involved_in response to laminar fluid shear stress PubMed 
involved_in response to lipid PubMed 
involved_in response to lipopolysaccharide PubMed 
involved_in response to organic cyclic compound PubMed 
involved_in response to progesterone PubMed 
involved_in response to xenobiotic stimulus PubMed 
involved_in superoxide anion generation  
involved_in superoxide anion generation  
acts_upstream_of_or_within superoxide anion generation  
involved_in superoxide anion generation  
Component Evidence Code Pubs
part_of NADPH oxidase complex  
part_of NADPH oxidase complex  
located_in acrosomal vesicle  
located_in acrosomal vesicle  
located_in cytoplasm  
located_in cytosol  
located_in cytosol  
located_in membrane  

General protein information

Preferred Names
neutrophil cytosol factor 2
Names
67 kDa neutrophil oxidase factor
neutrophil NADPH oxidase factor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001395185.1NP_001382114.1  neutrophil cytosol factor 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/TrEMBL
    A6ICU1, R4I3Z7
    Related
    ENSRNOP00000079682.1, ENSRNOT00000088724.3
    Conserved Domains (6) summary
    cd06406
    Location:351429
    PB1_P67; A PB1 domain is present in p67 proteins which forms a signaling complex with p40, a crucial step for activation of NADPH oxidase during phagocytosis. PB1 domain is a modular domain mediating specific protein-protein interactions which play a role in ...
    cd11871
    Location:244297
    SH3_p67phox_N; N-terminal (or first) Src Homology 3 domain of the p67phox subunit of NADPH oxidase
    cd12046
    Location:461512
    SH3_p67phox_C; C-terminal (or second) Src Homology 3 domain of the p67phox subunit of NADPH oxidase
    COG0457
    Location:4122
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:632
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:7199
    TPR_1; Tetratricopeptide repeat

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    67505492..67536015
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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