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Myh4 myosin heavy chain 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 360543, updated on 9-Dec-2024

Summary

Official Symbol
Myh4provided by RGD
Official Full Name
myosin heavy chain 4provided by RGD
Primary source
RGD:3139
See related
EnsemblRapid:ENSRNOG00000049695 AllianceGenome:RGD:3139
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable actin filament binding activity; double-stranded RNA binding activity; and microfilament motor activity. Involved in several processes, including response to gravity; response to muscle activity; and response to muscle stretch. Predicted to be located in myofibril. Predicted to be part of myosin II complex. Predicted to be active in cytoplasm and myosin filament. Biomarker of sciatic neuropathy. Orthologous to human MYH4 (myosin heavy chain 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Restricted expression toward (RPKM 80591.3) See more
Orthologs
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Genomic context

See Myh4 in Genome Data Viewer
Location:
10q24
Exon count:
40
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (52422148..52445296)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (51923149..51946297)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (53778456..53801605)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene myosin heavy chain 2 Neighboring gene uncharacterized LOC102555216 Neighboring gene myosin heavy chain 1 Neighboring gene myosin heavy chain 8 Neighboring gene myosin heavy chain 13

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Related articles in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding  
enables actin filament binding  
enables actin filament binding  
enables calmodulin binding  
enables double-stranded RNA binding  
enables microfilament motor activity  
Process Evidence Code Pubs
involved_in muscle contraction  
involved_in muscle contraction  
involved_in muscle structure development PubMed 
involved_in response to gravity PubMed 
involved_in response to muscle activity PubMed 
acts_upstream_of_or_within response to muscle activity  
involved_in response to muscle stretch PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm  
located_in myofibril  
part_of myosin II complex  
is_active_in myosin filament  
located_in myosin filament  

General protein information

Preferred Names
myosin-4
Names
2B myosin heavy chain
myHC-2b
myosin heavy chain 2b
myosin heavy chain type IIb
myosin, heavy chain 4, skeletal muscle
myosin, heavy polypeptide 4, skeletal muscle

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019325.1NP_062198.1  myosin-4

    See identical proteins and their annotated locations for NP_062198.1

    Status: PROVISIONAL

    Source sequence(s)
    BC113948
    UniProtKB/Swiss-Prot
    Q29RW1
    UniProtKB/TrEMBL
    F1LMU0
    Related
    ENSRNOP00000046362.3, ENSRNOT00000045718.6
    Conserved Domains (8) summary
    cd14915
    Location:100770
    MYSc_Myh4; class II myosin heavy chain 4, motor domain
    pfam00063
    Location:88770
    Myosin_head; Myosin head (motor domain)
    pfam01576
    Location:8501927
    Myosin_tail_1; Myosin tail
    pfam02736
    Location:3673
    Myosin_N; Myosin N-terminal SH3-like domain
    cl00459
    Location:12991411
    MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
    cl19219
    Location:15061582
    DUF342; Protein of unknown function (DUF342)
    cl19764
    Location:13761511
    COG6; Conserved oligomeric complex COG6
    cl23720
    Location:9941098
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    52422148..52445296
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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