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Edem2 ER degradation enhancing alpha-mannosidase like protein 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 296304, updated on 9-Dec-2024

Summary

Official Symbol
Edem2provided by RGD
Official Full Name
ER degradation enhancing alpha-mannosidase like protein 2provided by RGD
Primary source
RGD:1303074
See related
EnsemblRapid:ENSRNOG00000019299 AllianceGenome:RGD:1303074
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1303074
Summary
Predicted to enable mannosyl-oligosaccharide 1,2-alpha-mannosidase activity. Predicted to be involved in endoplasmic reticulum unfolded protein response; glycoprotein catabolic process; and positive regulation of retrograde protein transport, ER to cytosol. Predicted to be located in endoplasmic reticulum quality control compartment and membrane. Predicted to be active in endoplasmic reticulum. Orthologous to human EDEM2 (ER degradation enhancing alpha-mannosidase like protein 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Liver (RPKM 150.3), Spleen (RPKM 127.4) and 9 other tissues See more
Orthologs
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Genomic context

See Edem2 in Genome Data Viewer
Location:
3q42
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (164661741..164687559, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (144201604..144227423, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (151232741..151258559, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene myosin heavy chain 7B Neighboring gene microRNA 499a Neighboring gene transient receptor potential cation channel, subfamily C, member 4 associated protein Neighboring gene protein C receptor Neighboring gene proteasome maturation protein, pseudogene 2

Genomic regions, transcripts, and products

General gene information

Clone Names

  • MGC93956

Gene Ontology Provided by RGD

Component Evidence Code Pubs
located_in endoplasmic reticulum  
located_in endoplasmic reticulum quality control compartment  
located_in membrane  

General protein information

Preferred Names
ER degradation-enhancing alpha-mannosidase-like protein 2
Names
ER degradation enhancer, mannosidase alpha-like 2
ER degradation-enhancing alpha-mannosidase-like 2
ER degradation-enhancing-mannosidase-like protein 2
NP_001004230.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004230.1NP_001004230.1  ER degradation-enhancing alpha-mannosidase-like protein 2 precursor

    See identical proteins and their annotated locations for NP_001004230.1

    Status: PROVISIONAL

    Source sequence(s)
    BC079029
    UniProtKB/TrEMBL
    A0A8I6AA03, A6KI53, F7FAW8, Q6AYI8
    Related
    ENSRNOP00000026120.4, ENSRNOT00000026120.7
    Conserved Domains (1) summary
    pfam01532
    Location:42480
    Glyco_hydro_47; Glycosyl hydrolase family 47

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    164661741..164687559 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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