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Ptger1 prostaglandin E receptor 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25637, updated on 9-Dec-2024

Summary

Official Symbol
Ptger1provided by RGD
Official Full Name
prostaglandin E receptor 1provided by RGD
Primary source
RGD:3434
See related
EnsemblRapid:ENSRNOG00000004094 AllianceGenome:RGD:3434
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
EP1
Summary
Enables prostaglandin E receptor activity. Predicted to be involved in several processes, including adenylate cyclase-activating dopamine receptor signaling pathway; positive regulation of cytosolic calcium ion concentration; and response to prostaglandin E. Predicted to act upstream of or within response to lipopolysaccharide. Predicted to be active in plasma membrane. Used to study gastric ulcer. Orthologous to human PTGER1 (prostaglandin E receptor 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Lung (RPKM 58.9), Kidney (RPKM 51.2) and 9 other tissues See more
Orthologs
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Genomic context

See Ptger1 in Genome Data Viewer
Location:
19q11
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (41374983..41379593, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (24470258..24473687, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (24799422..24803373)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC120098561 Neighboring gene protein kinase N1 Neighboring gene GIPC PDZ domain containing family, member 1 Neighboring gene cytochrome c-like Neighboring gene ribosomal protein S10, pseudogene 10

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by RGD

Component Evidence Code Pubs
is_active_in plasma membrane  
located_in plasma membrane  
is_active_in plasma membrane  

General protein information

Preferred Names
prostaglandin E2 receptor EP1 subtype
Names
EP1 prostanoid receptor
PGE receptor, EP1 subtype
PGE2 receptor EP1 subtype
prostaglandin E receptor 1 (subtype EP1)
prostaglandin E receptor EP1 subtype
prostanoid EP1 receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278475.1NP_001265404.1  prostaglandin E2 receptor EP1 subtype

    See identical proteins and their annotated locations for NP_001265404.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000019
    UniProtKB/Swiss-Prot
    P70597, P97537
    UniProtKB/TrEMBL
    A6IYD3
    Conserved Domains (1) summary
    pfam00001
    Location:302354
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    41374983..41379593 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039097501.2XP_038953429.1  prostaglandin E2 receptor EP1 subtype isoform X1

    UniProtKB/TrEMBL
    A0A8I6A021, A6IYD4
    Related
    ENSRNOP00000084861.2, ENSRNOT00000113609.2
    Conserved Domains (2) summary
    cd14964
    Location:81107
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:80405
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

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