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    Sash1 SAM and SH3 domain containing 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 365037, updated on 9-Dec-2024

    Summary

    Official Symbol
    Sash1provided by RGD
    Official Full Name
    SAM and SH3 domain containing 1provided by RGD
    Primary source
    RGD:1566017
    See related
    EnsemblRapid:ENSRNOG00000013160 AllianceGenome:RGD:1566017
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1566017
    Summary
    Predicted to enable G-protein alpha-subunit binding activity; mitogen-activated protein kinase kinase kinase binding activity; and molecular adaptor activity. Predicted to be involved in positive regulation of non-canonical NF-kappaB signal transduction and regulation of epithelial cell migration. Predicted to act upstream of or within several processes, including positive regulation of angiogenesis; positive regulation of signal transduction; and regulation of protein modification process. Predicted to be located in cytosol; membrane; and nucleoplasm. Predicted to be part of protein-containing complex. Human ortholog(s) of this gene implicated in dyschromatosis universalis hereditaria. Orthologous to human SASH1 (SAM and SH3 domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 165.4), Kidney (RPKM 153.4) and 9 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Sash1 in Genome Data Viewer
    Location:
    1p13
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (4940207..5238777, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (3119915..3418536, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (2782905..2950749, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134484939 Neighboring gene RNA, U6 small nuclear 884 Neighboring gene small nucleolar RNA SNORA36 family Neighboring gene V-type proton ATPase catalytic subunit A-like Neighboring gene cytochrome c, somatic, pseudogene 7

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    General gene information

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in cytoplasm  
    located_in cytosol  
    located_in cytosol  
    located_in membrane  
    located_in nucleoplasm  
    located_in nucleoplasm  
    part_of protein-containing complex  

    General protein information

    Preferred Names
    SAM and SH3 domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427579.1NP_001414508.1  SAM and SH3 domain-containing protein 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I6G377, A0A8I6GLI1
      Related
      ENSRNOP00000076776.2, ENSRNOT00000095438.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      4940207..5238777 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039101481.2XP_038957409.1  SAM and SH3 domain-containing protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A8I6G377
      Conserved Domains (5) summary
      cd09492
      Location:12781347
      SAM_SASH1_repeat2; SAM domain of SASH1 proteins, repeat 2
      cd09559
      Location:748812
      SAM_SASH1_repeat1; SAM domain of SASH1 proteins, repeat 1
      cd11967
      Location:671727
      SH3_SASH1; Src homology 3 domain of SAM And SH3 Domain Containing Protein 1
      PHA03247
      Location:9361163
      PHA03247; large tegument protein UL36; Provisional
      pfam12485
      Location:517669
      SLY; Lymphocyte signaling adaptor protein
    2. XM_039101480.2XP_038957408.1  SAM and SH3 domain-containing protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A020
      Conserved Domains (5) summary
      cd09492
      Location:12811350
      SAM_SASH1_repeat2; SAM domain of SASH1 proteins, repeat 2
      cd09559
      Location:751815
      SAM_SASH1_repeat1; SAM domain of SASH1 proteins, repeat 1
      cd11967
      Location:674730
      SH3_SASH1; Src homology 3 domain of SAM And SH3 Domain Containing Protein 1
      PHA03247
      Location:9391166
      PHA03247; large tegument protein UL36; Provisional
      pfam12485
      Location:520672
      SLY; Lymphocyte signaling adaptor protein
    3. XM_039101479.2XP_038957407.1  SAM and SH3 domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6G377
      Related
      ENSRNOP00000096222.2, ENSRNOT00000112617.2
      Conserved Domains (5) summary
      cd09492
      Location:13231392
      SAM_SASH1_repeat2; SAM domain of SASH1 proteins, repeat 2
      cd09559
      Location:793857
      SAM_SASH1_repeat1; SAM domain of SASH1 proteins, repeat 1
      cd11967
      Location:716772
      SH3_SASH1; Src homology 3 domain of SAM And SH3 Domain Containing Protein 1
      PHA03247
      Location:9811208
      PHA03247; large tegument protein UL36; Provisional
      pfam12485
      Location:562714
      SLY; Lymphocyte signaling adaptor protein
    4. XM_039101484.2XP_038957412.1  SAM and SH3 domain-containing protein 1 isoform X5

      UniProtKB/TrEMBL
      F1LU97
      Conserved Domains (5) summary
      cd09492
      Location:10871156
      SAM_SASH1_repeat2; SAM domain of SASH1 proteins, repeat 2
      cd09559
      Location:557621
      SAM_SASH1_repeat1; SAM domain of SASH1 proteins, repeat 1
      cd11967
      Location:480536
      SH3_SASH1; Src homology 3 domain of SAM And SH3 Domain Containing Protein 1
      PHA03247
      Location:745972
      PHA03247; large tegument protein UL36; Provisional
      pfam12485
      Location:326478
      SLY; Lymphocyte signaling adaptor protein
    5. XM_039101486.2XP_038957414.1  SAM and SH3 domain-containing protein 1 isoform X7

      UniProtKB/TrEMBL
      A0A8I5Y723, F1LU97
      Conserved Domains (5) summary
      cd09492
      Location:925994
      SAM_SASH1_repeat2; SAM domain of SASH1 proteins, repeat 2
      cd09559
      Location:395459
      SAM_SASH1_repeat1; SAM domain of SASH1 proteins, repeat 1
      cd11967
      Location:318374
      SH3_SASH1; Src homology 3 domain of SAM And SH3 Domain Containing Protein 1
      PHA03247
      Location:583810
      PHA03247; large tegument protein UL36; Provisional
      pfam12485
      Location:162316
      SLY; Lymphocyte signaling adaptor protein
    6. XM_039101483.2XP_038957411.1  SAM and SH3 domain-containing protein 1 isoform X4

      UniProtKB/TrEMBL
      F1LU97
      Conserved Domains (5) summary
      cd09492
      Location:10991168
      SAM_SASH1_repeat2; SAM domain of SASH1 proteins, repeat 2
      cd09559
      Location:569633
      SAM_SASH1_repeat1; SAM domain of SASH1 proteins, repeat 1
      cd11967
      Location:492548
      SH3_SASH1; Src homology 3 domain of SAM And SH3 Domain Containing Protein 1
      PHA03247
      Location:757984
      PHA03247; large tegument protein UL36; Provisional
      pfam12485
      Location:338490
      SLY; Lymphocyte signaling adaptor protein
    7. XM_039101485.2XP_038957413.1  SAM and SH3 domain-containing protein 1 isoform X6

      UniProtKB/TrEMBL
      F1LU97
      Conserved Domains (5) summary
      cd09492
      Location:10461115
      SAM_SASH1_repeat2; SAM domain of SASH1 proteins, repeat 2
      cd09559
      Location:516580
      SAM_SASH1_repeat1; SAM domain of SASH1 proteins, repeat 1
      cd11967
      Location:439495
      SH3_SASH1; Src homology 3 domain of SAM And SH3 Domain Containing Protein 1
      PHA03247
      Location:704931
      PHA03247; large tegument protein UL36; Provisional
      pfam12485
      Location:285437
      SLY; Lymphocyte signaling adaptor protein
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