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    Abca8a ATP-binding cassette, subfamily A (ABC1), member 8a [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303638, updated on 9-Dec-2024

    Summary

    Official Symbol
    Abca8aprovided by RGD
    Official Full Name
    ATP-binding cassette, subfamily A (ABC1), member 8aprovided by RGD
    Primary source
    RGD:1307333
    See related
    EnsemblRapid:ENSRNOG00000004147 AllianceGenome:RGD:1307333
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ATPase-coupled transmembrane transporter activity and lipid transporter activity. Predicted to be involved in lipid transport. Predicted to be located in membrane. Predicted to be active in intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 582.0), Muscle (RPKM 530.6) and 8 other tissues See more
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    Genomic context

    See Abca8a in Genome Data Viewer
    Location:
    10q32.1
    Exon count:
    39
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (95501798..95571770, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (95002334..95072315, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (98319480..98390484, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L23a, pseudogene 1 Neighboring gene ATP binding cassette subfamily A member 8 Neighboring gene ATP binding cassette subfamily A member 9 Neighboring gene ATP binding cassette subfamily A member 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ABC-type transporter activity  
    enables ATP binding  
    enables ATP hydrolysis activity  
    enables ATPase-coupled transmembrane transporter activity  
    enables lipid transporter activity  
    Process Evidence Code Pubs
    involved_in biological_process  
    involved_in lipid transport  
    involved_in transmembrane transport  
    Component Evidence Code Pubs
    is_active_in intracellular membrane-bounded organelle  
    located_in membrane  

    General protein information

    Preferred Names
    ATP-binding cassette sub-family A member 8-A
    Names
    ATP-binding cassette, sub-family A (ABC1), member 8a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001281824.1NP_001268753.1  ATP-binding cassette sub-family A member 8-A

      See identical proteins and their annotated locations for NP_001268753.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      D3ZCF8
      Related
      ENSRNOP00000005665.6, ENSRNOT00000005665.8
      Conserved Domains (5) summary
      TIGR01188
      Location:493787
      drrA; daunorubicin resistance ABC transporter ATP-binding subunit
      cd03263
      Location:12791500
      ABC_subfamily_A; ATP-binding cassette domain of the lipid transporters, subfamily A
      COG1131
      Location:12721591
      CcmA; ABC-type multidrug transport system, ATPase component [Defense mechanisms]
      pfam12698
      Location:27416
      ABC2_membrane_3; ABC-2 family transporter protein
      pfam13664
      Location:267354
      DUF4149; Domain of unknown function (DUF4149)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      95501798..95571770 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006247611.5XP_006247673.1  ATP-binding cassette sub-family A member 8-A isoform X1

      See identical proteins and their annotated locations for XP_006247673.1

      UniProtKB/TrEMBL
      D3ZCF8
      Related
      ENSRNOP00000059943.4, ENSRNOT00000065947.6
      Conserved Domains (5) summary
      TIGR01188
      Location:493787
      drrA; daunorubicin resistance ABC transporter ATP-binding subunit
      cd03263
      Location:12791500
      ABC_subfamily_A; ATP-binding cassette domain of the lipid transporters, subfamily A
      COG1131
      Location:12721591
      CcmA; ABC-type multidrug transport system, ATPase component [Defense mechanisms]
      pfam12698
      Location:27416
      ABC2_membrane_3; ABC-2 family transporter protein
      pfam13664
      Location:267354
      DUF4149; Domain of unknown function (DUF4149)
    2. XM_063269226.1XP_063125296.1  ATP-binding cassette sub-family A member 8-A isoform X2

    RNA

    1. XR_005489862.2 RNA Sequence

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