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    Drd4 dopamine receptor D4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25432, updated on 9-Dec-2024

    Summary

    Official Symbol
    Drd4provided by RGD
    Official Full Name
    dopamine receptor D4provided by RGD
    Primary source
    RGD:2522
    See related
    EnsemblRapid:ENSRNOG00000017927 AllianceGenome:RGD:2522
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    D4RA
    Summary
    Enables dopamine binding activity; dopamine neurotransmitter receptor activity, coupled via Gi/Go; and heterocyclic compound binding activity. Involved in several processes, including learning or memory; modulation of chemical synaptic transmission; and regulation of signal transduction. Located in several cellular components, including cytoplasmic side of plasma membrane; dendrite; and perikaryon. Is active in GABA-ergic synapse; glutamatergic synapse; and synaptic membrane. Biomarker of attention deficit hyperactivity disorder and obesity. Human ortholog(s) of this gene implicated in several diseases, including Gilles de la Tourette syndrome; antisocial personality disorder; attention deficit hyperactivity disorder; conduct disorder; and substance abuse (multiple). Orthologous to human DRD4 (dopamine receptor D4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 5.8), Thymus (RPKM 0.8) and 3 other tissues See more
    Orthologs
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    Genomic context

    See Drd4 in Genome Data Viewer
    Location:
    1q41
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (205825937..205829124)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (196396366..196400824)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (214278296..214282818)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene cadherin-related family member 5 Neighboring gene secretin Neighboring gene DEAF1 transcription factor Neighboring gene transmembrane protein 80

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity  
    enables G protein-coupled serotonin receptor activity  
    enables SH3 domain binding  
    enables SH3 domain binding  
    enables dopamine binding PubMed 
    enables dopamine binding  
    enables dopamine binding PubMed 
    enables dopamine binding  
    enables dopamine neurotransmitter receptor activity  
    enables dopamine neurotransmitter receptor activity, coupled via Gi/Go PubMed 
    enables dopamine neurotransmitter receptor activity, coupled via Gi/Go  
    enables dopamine neurotransmitter receptor activity, coupled via Gi/Go  
    enables epinephrine binding  
    enables epinephrine binding  
    enables heterocyclic compound binding PubMed 
    enables heterocyclic compound binding PubMed 
    enables identical protein binding  
    enables identical protein binding  
    enables metal ion binding  
    enables neurotransmitter receptor activity  
    enables norepinephrine binding  
    enables norepinephrine binding  
    enables protein binding PubMed 
    Items 1 - 25 of 67
    Process Evidence Code Pubs
    involved_in G protein-coupled dopamine receptor signaling pathway PubMed 
    involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger  
    involved_in adenylate cyclase-inhibiting dopamine receptor signaling pathway  
    acts_upstream_of_or_within adenylate cyclase-inhibiting dopamine receptor signaling pathway  
    involved_in adenylate cyclase-inhibiting dopamine receptor signaling pathway  
    involved_in adenylate cyclase-inhibiting dopamine receptor signaling pathway  
    involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway  
    involved_in adult locomotory behavior  
    acts_upstream_of_or_within adult locomotory behavior  
    involved_in arachidonate secretion  
    involved_in arachidonate secretion  
    involved_in associative learning PubMed 
    involved_in behavioral fear response PubMed 
    involved_in behavioral response to cocaine  
    acts_upstream_of_or_within behavioral response to cocaine  
    involved_in chemical synaptic transmission  
    involved_in circadian rhythm PubMed 
    involved_in fear response  
    acts_upstream_of_or_within fear response  
    involved_in inhibitory postsynaptic potential  
    acts_upstream_of_or_within inhibitory postsynaptic potential  
    involved_in intracellular calcium ion homeostasis  
    involved_in intracellular calcium ion homeostasis  
    involved_in modulation of inhibitory postsynaptic potential PubMed 
    involved_in negative regulation of protein secretion  
    involved_in negative regulation of protein secretion  
    involved_in negative regulation of synaptic transmission PubMed 
    involved_in negative regulation of synaptic transmission, GABAergic PubMed 
    involved_in negative regulation of vascular associated smooth muscle cell migration PubMed 
    involved_in negative regulation of vascular associated smooth muscle cell proliferation PubMed 
    involved_in olfactory learning PubMed 
    involved_in phospholipase C-activating dopamine receptor signaling pathway  
    involved_in phospholipase C-activating dopamine receptor signaling pathway  
    involved_in photoperiodism PubMed 
    acts_upstream_of positive regulation of MAP kinase activity  
    involved_in positive regulation of excitatory postsynaptic potential PubMed 
    involved_in positive regulation of penile erection PubMed 
    involved_in prepulse inhibition PubMed 
    involved_in presynaptic modulation of chemical synaptic transmission PubMed 
    involved_in presynaptic modulation of chemical synaptic transmission PubMed 
    involved_in regulation of calcium-mediated signaling PubMed 
    involved_in regulation of circadian rhythm  
    involved_in regulation of circadian rhythm  
    involved_in regulation of circadian rhythm  
    involved_in regulation of dopamine metabolic process  
    acts_upstream_of_or_within regulation of dopamine metabolic process  
    involved_in regulation of locomotion  
    involved_in regulation of neurotransmitter secretion PubMed 
    involved_in regulation of postsynaptic membrane neurotransmitter receptor levels PubMed 
    involved_in regulation of postsynaptic membrane neurotransmitter receptor levels PubMed 
    involved_in regulation of postsynaptic membrane neurotransmitter receptor levels PubMed 
    involved_in regulation of postsynaptic neurotransmitter receptor internalization  
    involved_in regulation of postsynaptic neurotransmitter receptor internalization  
    involved_in regulation of protein kinase A signaling PubMed 
    involved_in response to amphetamine  
    acts_upstream_of_or_within response to amphetamine  
    involved_in response to epinephrine PubMed 
    involved_in response to ethanol PubMed 
    involved_in response to histamine  
    involved_in response to histamine  
    involved_in response to light stimulus PubMed 
    involved_in response to steroid hormone PubMed 
    involved_in response to thyroid hormone PubMed 
    involved_in retina development in camera-type eye PubMed 
    involved_in short-term memory PubMed 
    involved_in synaptic transmission, dopaminergic  
    involved_in synaptic transmission, dopaminergic PubMed 
    Items 1 - 25 of 67
    Items 1 - 20 of 36
    Component Evidence Code Pubs
    is_active_in GABA-ergic synapse PubMed 
    is_active_in GABA-ergic synapse PubMed 
    located_in Golgi apparatus PubMed 
    located_in axon PubMed 
    located_in axon terminus PubMed 
    located_in cell cortex PubMed 
    located_in centrosome  
    located_in centrosome  
    located_in cytoplasm PubMed 
    located_in cytoplasmic side of plasma membrane PubMed 
    is_active_in dendrite  
    located_in dendrite PubMed 
    located_in dendrite terminus PubMed 
    located_in dendritic microtubule PubMed 
    located_in dendritic shaft PubMed 
    located_in dendritic spine PubMed 
    located_in endoplasmic reticulum PubMed 
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse PubMed 
    located_in glutamatergic synapse  
    is_active_in glutamatergic synapse  
    located_in membrane  
    located_in mitochondrion PubMed 
    located_in neuronal cell body PubMed 
    located_in perikaryon PubMed 
    is_active_in plasma membrane  
    located_in plasma membrane PubMed 
    located_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane  
    located_in postsynapse  
    is_active_in postsynaptic membrane PubMed 
    located_in presynapse PubMed 
    is_active_in presynaptic membrane PubMed 
    located_in synapse PubMed 
    located_in terminal bouton PubMed 
    Items 1 - 20 of 36

    General protein information

    Preferred Names
    D(4) dopamine receptor
    Names
    d(2C) dopamine receptor
    dopamine D4 receptor
    dopamine receptor 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012944.2NP_037076.2  D(4) dopamine receptor

      See identical proteins and their annotated locations for NP_037076.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      P30729, Q62610
      UniProtKB/TrEMBL
      A6HXT7, F1LLX2
      Conserved Domains (1) summary
      pfam00001
      Location:50368
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      205825937..205829124
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006230521.4XP_006230583.1  D(4) dopamine receptor isoform X1

      UniProtKB/Swiss-Prot
      P30729, Q62610
      Related
      ENSRNOP00000024137.4, ENSRNOT00000024137.6
      Conserved Domains (1) summary
      pfam00001
      Location:50370
      7tm_1; 7 transmembrane receptor (rhodopsin family)
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