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    Pln phospholamban [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64672, updated on 9-Dec-2024

    Summary

    Official Symbol
    Plnprovided by RGD
    Official Full Name
    phospholambanprovided by RGD
    Primary source
    RGD:619894
    See related
    EnsemblRapid:ENSRNOG00000079579 AllianceGenome:RGD:619894
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Plm
    Summary
    Enables ATPase inhibitor activity and identical protein binding activity. Involved in several processes, including response to insulin; response to testosterone; and response to zinc ion. Located in sarcoplasmic reticulum and vesicle. Part of protein-containing complex. Used to study congestive heart failure; heart disease; and myocardial infarction. Biomarker of myocardial infarction and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 1P and hypertrophic cardiomyopathy 18. Orthologous to human PLN (phospholamban). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 9042.3) See more
    Orthologs
    NEW
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    Genomic context

    See Pln in Genome Data Viewer
    Location:
    20q11
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (33166512..33182241)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (32629537..32639559)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (34633157..34642904)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 35, member F1 Neighboring gene uncharacterized LOC120098878 Neighboring gene uncharacterized LOC134483813 Neighboring gene centrosomal protein 85-like Neighboring gene NADH:ubiquinone oxidoreductase subunit B4, pseudogene 9 Neighboring gene minichromosome maintenance 9 homologous recombination repair factor Neighboring gene anti-silencing function 1A histone chaperone Neighboring gene minichromosome maintenance 9 homologous recombination repair factor like

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATPase inhibitor activity  
    enables ATPase inhibitor activity PubMed 
    enables ATPase inhibitor activity  
    enables identical protein binding PubMed 
    enables protein binding PubMed 
    enables protein homodimerization activity  
    enables protein homodimerization activity  
    Items 1 - 25 of 46
    Process Evidence Code Pubs
    acts_upstream_of_or_within Notch signaling pathway  
    involved_in acrosome assembly  
    involved_in acrosome assembly  
    acts_upstream_of_or_within adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process  
    involved_in calcium ion transport PubMed 
    involved_in calcium ion transport PubMed 
    acts_upstream_of_or_within cardiac muscle tissue development  
    involved_in circadian sleep/wake cycle, sleep  
    involved_in circadian sleep/wake cycle, sleep  
    acts_upstream_of_or_within intracellular calcium ion homeostasis  
    involved_in intracellular calcium ion homeostasis  
    involved_in intracellular calcium ion homeostasis  
    involved_in locomotor rhythm  
    involved_in locomotor rhythm  
    acts_upstream_of_or_within muscle cell cellular homeostasis  
    involved_in negative regulation of ATP-dependent activity  
    acts_upstream_of_or_within negative regulation of ATPase-coupled calcium transmembrane transporter activity  
    involved_in negative regulation of ATPase-coupled calcium transmembrane transporter activity  
    involved_in negative regulation of ATPase-coupled calcium transmembrane transporter activity  
    involved_in negative regulation of calcium ion import into sarcoplasmic reticulum  
    involved_in negative regulation of calcium ion import into sarcoplasmic reticulum  
    involved_in negative regulation of calcium ion import into sarcoplasmic reticulum  
    involved_in negative regulation of calcium ion transmembrane transporter activity  
    involved_in negative regulation of calcium ion transport  
    acts_upstream_of_or_within negative regulation of heart contraction  
    involved_in negative regulation of heart rate  
    involved_in negative regulation of heart rate  
    involved_in regulation of ATPase-coupled calcium transmembrane transporter activity  
    acts_upstream_of_or_within regulation of calcium ion import  
    involved_in regulation of calcium ion transport  
    involved_in regulation of calcium ion transport  
    acts_upstream_of_or_within regulation of cardiac muscle cell contraction  
    acts_upstream_of_or_within regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion  
    acts_upstream_of_or_within regulation of heart contraction  
    involved_in regulation of heart contraction  
    acts_upstream_of_or_within regulation of relaxation of muscle  
    acts_upstream_of_or_within regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum  
    acts_upstream_of_or_within regulation of ryanodine-sensitive calcium-release channel activity  
    acts_upstream_of_or_within regulation of the force of heart contraction  
    acts_upstream_of_or_within regulation of the force of heart contraction by cardiac conduction  
    involved_in response to insulin PubMed 
    involved_in response to testosterone PubMed 
    involved_in response to zinc ion PubMed 
    involved_in spermatogenesis  
    involved_in visual learning  
    involved_in visual learning  
    Items 1 - 25 of 46
    Component Evidence Code Pubs
    part_of calcium ion-transporting ATPase complex  
    is_active_in endoplasmic reticulum membrane  
    located_in endoplasmic reticulum membrane  
    located_in endoplasmic reticulum membrane  
    is_active_in membrane  
    located_in membrane  
    located_in mitochondrial membrane  
    part_of protein-containing complex PubMed 
    is_active_in sarcoplasmic reticulum  
    located_in sarcoplasmic reticulum PubMed 
    located_in sarcoplasmic reticulum  
    located_in sarcoplasmic reticulum membrane  
    located_in sarcoplasmic reticulum membrane  
    located_in vesicle PubMed 

    General protein information

    Preferred Names
    cardiac phospholamban
    Names
    PLB

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022707.2 → NP_073198.1  cardiac phospholamban

      See identical proteins and their annotated locations for NP_073198.1

      Status: VALIDATED

      Source sequence(s)
      CK356371, FM050525, FM055105, FM056997, FM111426
      UniProtKB/Swiss-Prot
      P61016
      UniProtKB/TrEMBL
      A6K492
      Related
      ENSRNOP00000105613.1, ENSRNOT00000122906.1
      Conserved Domains (1) summary
      TIGR01294
      Location:1 → 52
      P_lamban; phospholamban

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      33166512..33182241
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039099053.2 → XP_038954981.1  cardiac phospholamban isoform X1

      UniProtKB/Swiss-Prot
      P61016
      UniProtKB/TrEMBL
      A6K492
      Conserved Domains (1) summary
      TIGR01294
      Location:1 → 52
      P_lamban; phospholamban
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