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Impdh2 inosine monophosphate dehydrogenase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 301005, updated on 9-Dec-2024

Summary

Official Symbol
Impdh2provided by RGD
Official Full Name
inosine monophosphate dehydrogenase 2provided by RGD
Primary source
RGD:735092
See related
EnsemblRapid:ENSRNOG00000031965 AllianceGenome:RGD:735092
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
IMPD 2; IMPDH 2
Summary
Enables IMP dehydrogenase activity and identical protein binding activity. Involved in retina development in camera-type eye. Predicted to be located in cytosol and nucleus. Predicted to be active in cytoplasm. Orthologous to human IMPDH2 (inosine monophosphate dehydrogenase 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Spleen (RPKM 642.9), Thymus (RPKM 626.9) and 9 other tissues See more
Orthologs
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Genomic context

See Impdh2 in Genome Data Viewer
Location:
8q32
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (118135204..118139892)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (109256705..109261365)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (117346983..117351619)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene glutaminyl-tRNA synthetase 1 Neighboring gene glutamine-rich 1 Neighboring gene NADH:ubiquinone oxidoreductase complex assembly factor 3 Neighboring gene microRNA 3555 Neighboring gene DALR anticodon binding domain containing 3 Neighboring gene microRNA 191 Neighboring gene microRNA 425

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Clone Names

  • MGC72938

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables IMP dehydrogenase activity  
enables IMP dehydrogenase activity PubMed 
enables IMP dehydrogenase activity  
enables IMP dehydrogenase activity  
enables identical protein binding PubMed 
enables metal ion binding  
enables nucleotide binding  
enables nucleotide binding  
Process Evidence Code Pubs
involved_in 'de novo' XMP biosynthetic process  
involved_in 'de novo' XMP biosynthetic process  
involved_in GMP biosynthetic process  
involved_in GMP biosynthetic process  
involved_in GTP biosynthetic process  
involved_in GTP biosynthetic process  
involved_in GTP biosynthetic process  
involved_in GTP biosynthetic process  
involved_in cellular response to interleukin-4  
acts_upstream_of_or_within cellular response to interleukin-4  
involved_in circadian rhythm  
involved_in circadian rhythm  
involved_in circadian rhythm  
involved_in lymphocyte proliferation  
acts_upstream_of_or_within lymphocyte proliferation  
acts_upstream_of_or_within purine nucleotide biosynthetic process  
involved_in retina development in camera-type eye PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm  
located_in cytoplasm  
located_in cytosol  
located_in cytosol  
located_in cytosol  
located_in nucleus  
located_in nucleus  

General protein information

Preferred Names
inosine-5'-monophosphate dehydrogenase 2
Names
IMP (inosine 5'-monophosphate) dehydrogenase 2
IMP (inosine monophosphate) dehydrogenase 2
IMP dehydrogenase 2
inosine 5'-phosphate dehydrogenase 2
inosine 5-monophosphate dehydrogenase 2
NP_954530.2
XP_006243813.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199099.3NP_954530.2  inosine-5'-monophosphate dehydrogenase 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/Swiss-Prot
    E9PU28
    UniProtKB/TrEMBL
    Q6P9U9
    Related
    ENSRNOP00000040635.3, ENSRNOT00000047717.6
    Conserved Domains (1) summary
    PLN02274
    Location:15514
    PLN02274; inosine-5'-monophosphate dehydrogenase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    118135204..118139892
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006243751.5XP_006243813.1  inosine-5'-monophosphate dehydrogenase 2 isoform X1

    UniProtKB/TrEMBL
    Q6P9U9
    Related
    ENSRNOP00000108718.1, ENSRNOT00000166384.1
    Conserved Domains (3) summary
    PLN02274
    Location:15538
    PLN02274; inosine-5'-monophosphate dehydrogenase
    cd00381
    Location:29504
    IMPDH; IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine ...
    cd04602
    Location:115230
    CBS_pair_IMPDH_2; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key ...
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