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Cdh2 cadherin 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 83501, updated on 9-Dec-2024

Summary

Official Symbol
Cdh2provided by RGD
Official Full Name
cadherin 2provided by RGD
Primary source
RGD:69280
See related
EnsemblRapid:ENSRNOG00000015602 AllianceGenome:RGD:69280
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
N-cadherin
Summary
Enables beta-catenin binding activity; nitric-oxide synthase binding activity; and protein tyrosine kinase binding activity. Involved in several processes, including calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; regulation of Rho protein signal transduction; and regulation of myelination. Located in several cellular components, including T-tubule; adherens junction; and fascia adherens. Part of protein-containing complex. Is active in glutamatergic synapse. Human ortholog(s) of this gene implicated in agenesis of corpus callosum, cardiac, ocular, and genital syndrome; arrhythmogenic right ventricular cardiomyopathy; and arrhythmogenic right ventricular dysplasia 14. Orthologous to human CDH2 (cadherin 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Heart (RPKM 381.9), Liver (RPKM 194.3) and 6 other tissues See more
Orthologs
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Genomic context

See Cdh2 in Genome Data Viewer
Location:
18p13
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (8051097..8265288, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (7776704..7990934, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (8146971..8366037, complement)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L27a pseudogene Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC120098221 Neighboring gene uncharacterized LOC134482995 Neighboring gene small nucleolar RNA SNORA17

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

General gene information

Gene Ontology Provided by RGD

Items 1 - 25 of 26
Function Evidence Code Pubs
enables RNA binding  
enables RNA binding  
enables alpha-catenin binding  
enables alpha-catenin binding  
enables beta-catenin binding  
enables beta-catenin binding  
enables beta-catenin binding PubMed 
enables beta-catenin binding  
enables cadherin binding  
enables calcium ion binding  
enables calcium ion binding  
enables calcium ion binding  
enables enzyme binding  
enables gamma-catenin binding  
enables gamma-catenin binding  
enables identical protein binding  
enables identical protein binding  
enables nitric-oxide synthase binding PubMed 
enables protein binding PubMed 
enables protein kinase binding  
enables protein kinase binding PubMed 
enables protein kinase binding  
enables protein phosphatase binding  
enables protein phosphatase binding  
enables protein tyrosine kinase binding PubMed 
enables protein-containing complex binding PubMed 
Items 1 - 25 of 26
Items 1 - 25 of 76
Process Evidence Code Pubs
involved_in adherens junction organization  
involved_in blood vessel morphogenesis  
acts_upstream_of_or_within blood vessel morphogenesis  
involved_in brain morphogenesis  
acts_upstream_of_or_within brain morphogenesis  
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules  
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules  
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules PubMed 
acts_upstream_of_or_within calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules  
acts_upstream_of_or_within cell adhesion  
involved_in cell migration  
acts_upstream_of_or_within cell migration  
involved_in cell morphogenesis  
involved_in cell-cell adhesion PubMed 
involved_in cell-cell adhesion  
involved_in cell-cell adhesion mediated by cadherin  
involved_in cell-cell adhesion mediated by cadherin  
involved_in cell-cell adhesion mediated by cadherin  
involved_in cell-cell adhesion mediated by cadherin  
involved_in cell-cell junction assembly  
involved_in cell-cell junction assembly  
involved_in cell-cell junction assembly  
involved_in cell-cell junction assembly  
involved_in cerebral cortex development  
acts_upstream_of_or_within cerebral cortex development  
involved_in glial cell differentiation  
involved_in glial cell differentiation  
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules  
acts_upstream_of_or_within heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules  
involved_in homeostasis of number of cells  
acts_upstream_of_or_within homeostasis of number of cells  
involved_in homophilic cell adhesion via plasma membrane adhesion molecules  
acts_upstream_of_or_within homophilic cell adhesion via plasma membrane adhesion molecules  
involved_in mesenchymal cell migration  
acts_upstream_of_or_within mesenchymal cell migration  
involved_in modulation of chemical synaptic transmission PubMed 
involved_in modulation of chemical synaptic transmission PubMed 
involved_in negative regulation of canonical Wnt signaling pathway  
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway  
involved_in neural crest cell development  
involved_in neural crest cell development  
involved_in neural crest cell development  
involved_in neuroepithelial cell differentiation  
acts_upstream_of_or_within neuroepithelial cell differentiation  
involved_in neuroligin clustering involved in postsynaptic membrane assembly  
involved_in neuroligin clustering involved in postsynaptic membrane assembly  
involved_in neuronal stem cell population maintenance  
involved_in neuronal stem cell population maintenance  
involved_in neuronal stem cell population maintenance  
involved_in positive regulation of MAPK cascade  
acts_upstream_of_or_within positive regulation of MAPK cascade  
involved_in positive regulation of synaptic vesicle clustering  
involved_in positive regulation of synaptic vesicle clustering  
involved_in protein localization to plasma membrane  
involved_in protein localization to plasma membrane  
involved_in radial glial cell differentiation  
acts_upstream_of_or_within radial glial cell differentiation  
involved_in regulation of Rho protein signal transduction PubMed 
involved_in regulation of axonogenesis PubMed 
involved_in regulation of myelination PubMed 
involved_in regulation of oligodendrocyte progenitor proliferation  
acts_upstream_of_or_within regulation of oligodendrocyte progenitor proliferation  
involved_in regulation of postsynaptic density protein 95 clustering  
involved_in regulation of postsynaptic density protein 95 clustering  
involved_in regulation of protein localization PubMed 
involved_in striated muscle cell differentiation  
acts_upstream_of_or_within striated muscle cell differentiation  
involved_in synapse assembly  
involved_in synapse assembly PubMed 
involved_in synaptic vesicle clustering  
involved_in synaptic vesicle clustering  
involved_in synaptic vesicle clustering  
acts_upstream_of_or_within telencephalon development  
involved_in type B pancreatic cell development  
involved_in type B pancreatic cell development  
involved_in type B pancreatic cell development  
Items 1 - 25 of 76
Items 1 - 20 of 55
Component Evidence Code Pubs
located_in T-tubule PubMed 
is_active_in adherens junction  
located_in adherens junction PubMed 
located_in adherens junction  
located_in adherens junction  
is_active_in apical part of cell  
located_in apical plasma membrane  
located_in apical plasma membrane  
located_in apicolateral plasma membrane  
located_in apicolateral plasma membrane  
located_in basolateral plasma membrane  
located_in basolateral plasma membrane  
part_of catenin complex  
part_of catenin complex  
part_of catenin complex  
located_in cell junction  
located_in cell surface  
located_in cell surface  
located_in cell surface  
located_in cell-cell junction  
located_in cortical actin cytoskeleton  
located_in cortical actin cytoskeleton  
is_active_in cytoplasm  
located_in cytoplasm  
located_in desmosome PubMed 
located_in desmosome  
located_in desmosome  
located_in desmosome  
located_in fascia adherens PubMed 
located_in fascia adherens  
located_in fascia adherens  
is_active_in glutamatergic synapse PubMed 
is_active_in glutamatergic synapse PubMed 
is_active_in intercalated disc  
located_in intercalated disc PubMed 
located_in intercalated disc  
is_active_in lamellipodium  
located_in lamellipodium  
located_in lamellipodium  
located_in membrane PubMed 
is_active_in neuron projection  
located_in plasma membrane PubMed 
located_in plasma membrane  
located_in plasma membrane  
located_in plasma membrane raft  
located_in plasma membrane raft  
is_active_in postsynaptic density  
is_active_in postsynaptic specialization membrane  
located_in presynapse  
is_active_in presynaptic active zone membrane  
part_of protein-containing complex PubMed 
located_in sarcolemma  
located_in sarcolemma  
located_in synapse PubMed 
located_in synapse  
Items 1 - 20 of 55

General protein information

Preferred Names
cadherin-2
Names
cadherin 2, type 1, N-cadherin (neuronal)
neural cadherin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031333.2NP_112623.2  cadherin-2 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/Swiss-Prot
    Q9R0T5, Q9Z1Y3
    UniProtKB/TrEMBL
    A6J2E5, G3V803
    Related
    ENSRNOP00000021170.5, ENSRNOT00000021170.8
    Conserved Domains (5) summary
    cd11304
    Location:273378
    Cadherin_repeat; Cadherin tandem repeat domain
    pfam01049
    Location:751904
    Cadherin_C; Cadherin cytoplasmic region
    pfam08758
    Location:31121
    Cadherin_pro; Cadherin prodomain like
    cl28889
    Location:163263
    CA_like; Cadherin repeat-like domain
    cl29226
    Location:608701
    Cadherin; Cadherin domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    8051097..8265288 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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