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Lgmn legumain [ Rattus norvegicus (Norway rat) ]

Gene ID: 63865, updated on 9-Dec-2024

Summary

Official Symbol
Lgmnprovided by RGD
Official Full Name
legumainprovided by RGD
Primary source
RGD:619832
See related
EnsemblRapid:ENSRNOG00000007089 AllianceGenome:RGD:619832
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Prsc1
Summary
Enables cysteine-type endopeptidase activity. Predicted to be involved in several processes, including learning or memory; positive regulation of chemotaxis; and protein processing. Predicted to act upstream of or within negative regulation of neuron apoptotic process; regulation of growth; and response to acidic pH. Located in lysosome. Orthologous to human LGMN (legumain). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Kidney (RPKM 2645.7), Spleen (RPKM 942.6) and 9 other tissues See more
Orthologs
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Genomic context

See Lgmn in Genome Data Viewer
Location:
6q32
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (127308913..127347355, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (121544048..121582495, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (126282246..126308207, complement)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 24 member 4 Neighboring gene Ras and Rab interactor 3 Neighboring gene uncharacterized LOC134479252 Neighboring gene uncharacterized LOC102548124 Neighboring gene golgin A5

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Clone Names

  • MGC105274

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cysteine-type endopeptidase activity  
enables cysteine-type endopeptidase activity  
enables cysteine-type endopeptidase activity PubMed 
enables cysteine-type endopeptidase activity  
enables cysteine-type endopeptidase activity  
enables endopeptidase activator activity  
enables endopeptidase activator activity  
enables peptidase activity  
Items 1 - 25 of 56
Process Evidence Code Pubs
involved_in activation of cysteine-type endopeptidase activity  
involved_in antigen processing and presentation of exogenous peptide antigen via MHC class II  
involved_in antigen processing and presentation of exogenous peptide antigen via MHC class II  
involved_in antigen processing and presentation of exogenous peptide antigen via MHC class II  
involved_in associative learning  
involved_in associative learning  
involved_in cellular response to amyloid-beta  
involved_in cellular response to amyloid-beta  
involved_in cellular response to calcium ion  
involved_in cellular response to calcium ion  
involved_in cellular response to hepatocyte growth factor stimulus  
involved_in cellular response to hepatocyte growth factor stimulus  
involved_in dendritic spine organization  
involved_in dendritic spine organization  
involved_in memory  
involved_in memory  
involved_in negative regulation of ERBB signaling pathway  
involved_in negative regulation of ERBB signaling pathway  
involved_in negative regulation of ERBB signaling pathway  
involved_in negative regulation of gene expression  
involved_in negative regulation of gene expression  
involved_in negative regulation of multicellular organism growth  
acts_upstream_of_or_within negative regulation of multicellular organism growth  
involved_in negative regulation of neuron apoptotic process  
acts_upstream_of_or_within negative regulation of neuron apoptotic process  
involved_in positive regulation of cell population proliferation  
involved_in positive regulation of cell population proliferation  
involved_in positive regulation of endothelial cell chemotaxis  
involved_in positive regulation of endothelial cell chemotaxis  
involved_in positive regulation of long-term synaptic potentiation  
involved_in positive regulation of long-term synaptic potentiation  
involved_in positive regulation of mitotic cell cycle  
involved_in positive regulation of mitotic cell cycle  
involved_in positive regulation of monocyte chemotaxis  
involved_in positive regulation of monocyte chemotaxis  
involved_in protein maturation  
involved_in protein maturation  
acts_upstream_of_or_within proteolysis  
involved_in proteolysis  
involved_in proteolysis  
involved_in proteolysis involved in protein catabolic process  
involved_in proteolysis involved in protein catabolic process  
involved_in proteolysis involved in protein catabolic process  
involved_in proteolysis involved in protein catabolic process  
involved_in receptor catabolic process  
involved_in receptor catabolic process  
involved_in receptor catabolic process  
involved_in renal system process  
involved_in renal system process  
involved_in renal system process  
involved_in response to acidic pH  
acts_upstream_of_or_within response to acidic pH  
involved_in response to acidic pH  
involved_in self proteolysis  
involved_in self proteolysis  
involved_in vacuolar protein processing  
Items 1 - 25 of 56
Component Evidence Code Pubs
located_in apical part of cell  
located_in apical part of cell  
located_in cytoplasm  
located_in extracellular region  
located_in extracellular region  
located_in late endosome  
located_in late endosome  
located_in lysosomal lumen  
is_active_in lysosomal lumen  
is_active_in lysosomal lumen  
located_in lysosome PubMed 
located_in lysosome  
located_in perinuclear region of cytoplasm  
located_in perinuclear region of cytoplasm  

General protein information

Preferred Names
legumain
Names
asparaginyl endopeptidase
protease, cysteine 1
protease, cysteine, 1 (legumain)
NP_071562.3
XP_038968798.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022226.3NP_071562.3  legumain precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/Swiss-Prot
    Q9JLN3, Q9R0J8
    UniProtKB/TrEMBL
    A6JEK1, F7EX67, Q5PPG2
    Related
    ENSRNOP00000010101.3, ENSRNOT00000010101.7
    Conserved Domains (2) summary
    pfam01650
    Location:31287
    Peptidase_C13; Peptidase C13 family
    cd21115
    Location:311431
    legumain_C; C-terminal prodomain of legumain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    127308913..127347355 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039112870.1XP_038968798.1  legumain isoform X1

    UniProtKB/Swiss-Prot
    Q9JLN3, Q9R0J8
    UniProtKB/TrEMBL
    A6JEK1, F7EX67, Q5PPG2
    Conserved Domains (2) summary
    pfam01650
    Location:31287
    Peptidase_C13; Peptidase C13 family
    cd21115
    Location:311431
    legumain_C; C-terminal prodomain of legumain
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