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Hk1 hexokinase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25058, updated on 9-Dec-2024

Summary

Official Symbol
Hk1provided by RGD
Official Full Name
hexokinase 1provided by RGD
Primary source
RGD:2796
See related
EnsemblRapid:ENSRNOG00000046891 AllianceGenome:RGD:2796
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
HKI; HEXOKIN
Summary
Enables several functions, including ATP binding activity; D-glucose binding activity; and hexokinase activity. Involved in several processes, including phosphorylation; response to ischemia; and response to ketamine. Located in caveola and mitochondrion. Part of protein-containing complex. Used to study obesity and urinary bladder cancer. Biomarker of colorectal cancer and pulmonary hypertension. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 4G; anemia (multiple); hematologic cancer (multiple); obesity; and retinitis pigmentosa. Orthologous to human HK1 (hexokinase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Testes (RPKM 630.4), Brain (RPKM 381.5) and 8 other tissues See more
Orthologs
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Genomic context

See Hk1 in Genome Data Viewer
Location:
20q11
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (30773222..30874814, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (30230488..30332099, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (31911460..31979780, complement)

Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene cytosolic iron-sulfur assembly component 2A, pseudogene 1 Neighboring gene tachykinin receptor 2 Neighboring gene synaptic defective enhancer 1-like Neighboring gene uncharacterized LOC134483920 Neighboring gene hexokinase domain containing 1 Neighboring gene Suv3 like RNA helicase

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding PubMed 
enables ATP binding PubMed 
enables ATP binding  
enables ATP hydrolysis activity PubMed 
enables D-glucose binding PubMed 
enables D-glucose binding  
enables fructokinase activity  
enables fructokinase activity PubMed 
enables glucokinase activity  
enables glucokinase activity PubMed 
enables glucokinase activity  
enables glucokinase activity  
enables glucosamine kinase activity  
enables hexokinase activity PubMed 
enables hexokinase activity  
enables hexokinase activity  
enables identical protein binding PubMed 
enables mannokinase activity  
enables mannokinase activity PubMed 
enables mannokinase activity  
enables peptidoglycan binding  
enables peptidoglycan binding  
enables protein binding PubMed 
enables protein kinase activity PubMed 
enables protein-containing complex binding PubMed 
Items 1 - 25 of 42
Process Evidence Code Pubs
involved_in GDP-mannose biosynthetic process from glucose  
involved_in GDP-mannose biosynthetic process from glucose  
involved_in GDP-mannose biosynthetic process from mannose  
involved_in GDP-mannose biosynthetic process from mannose  
involved_in canonical glycolysis  
involved_in canonical glycolysis  
involved_in carbohydrate phosphorylation PubMed 
involved_in carbohydrate phosphorylation  
involved_in carbohydrate phosphorylation  
involved_in establishment of protein localization to mitochondrion  
involved_in establishment of protein localization to mitochondrion  
involved_in fructose 6-phosphate metabolic process PubMed 
involved_in glucose 6-phosphate metabolic process  
involved_in glucose 6-phosphate metabolic process PubMed 
involved_in glucose 6-phosphate metabolic process  
involved_in glucose metabolic process  
involved_in glycolytic process  
involved_in glycolytic process PubMed 
involved_in glycolytic process  
involved_in hexose metabolic process  
involved_in inflammatory response  
involved_in innate immune response  
involved_in intracellular glucose homeostasis  
involved_in intracellular glucose homeostasis  
involved_in maintenance of protein location in mitochondrion  
involved_in maintenance of protein location in mitochondrion  
involved_in mannose metabolic process PubMed 
involved_in negative regulation of apoptotic process PubMed 
involved_in peptidyl-serine phosphorylation PubMed 
involved_in peptidyl-threonine phosphorylation PubMed 
involved_in peptidyl-tyrosine phosphorylation PubMed 
involved_in positive regulation of cytokine production involved in immune response  
involved_in positive regulation of cytokine production involved in immune response  
involved_in positive regulation of interleukin-1 beta production  
involved_in positive regulation of interleukin-1 beta production  
involved_in protein autophosphorylation PubMed 
involved_in protein phosphorylation PubMed 
involved_in regulation of anion channel activity PubMed 
involved_in response to brassinosteroid PubMed 
involved_in response to hypoxia PubMed 
involved_in response to ischemia PubMed 
involved_in response to ketamine PubMed 
Items 1 - 25 of 42
Component Evidence Code Pubs
located_in caveola PubMed 
is_active_in cytosol  
located_in cytosol  
is_active_in cytosol  
located_in cytosol  
located_in membrane raft  
located_in membrane raft  
located_in mitochondrial outer membrane  
is_active_in mitochondrion  
located_in mitochondrion PubMed 
located_in mitochondrion  
part_of protein-containing complex PubMed 

General protein information

Preferred Names
hexokinase-1
Names
brain form hexokinase
hexokinase type I
hexokinase-A
NP_001380640.1
NP_036866.2
XP_038954360.2
XP_038954362.1
XP_038954363.1
XP_063135041.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001393711.1 → NP_001380640.1  hexokinase-1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000020
    UniProtKB/TrEMBL
    A0A8I5YBQ4
    Related
    ENSRNOP00000077266.1, ENSRNOT00000099595.2
    Conserved Domains (3) summary
    PTZ00107
    Location:23 → 464
    PTZ00107; hexokinase; Provisional
    pfam00349
    Location:473 → 671
    Hexokinase_1
    pfam03727
    Location:677 → 911
    Hexokinase_2
  2. NM_012734.2 → NP_036866.2  hexokinase-1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000020
    UniProtKB/Swiss-Prot
    P05708
    UniProtKB/TrEMBL
    A0A8I6AJ28
    Related
    ENSRNOP00000098666.1, ENSRNOT00000168329.1
    Conserved Domains (1) summary
    PTZ00107
    Location:462 → 907
    PTZ00107; hexokinase; Provisional

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086038.1 Reference GRCr8

    Range
    30773222..30874814 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039098432.2 → XP_038954360.2  hexokinase-1 isoform X1

    UniProtKB/TrEMBL
    A0A8I5YBQ4, A0A8I6AUZ1
    Related
    ENSRNOP00000097442.1, ENSRNOT00000112632.2
  2. XM_039098434.2 → XP_038954362.1  hexokinase-1 isoform X2

    UniProtKB/TrEMBL
    A0A8I5YBQ4
    Conserved Domains (3) summary
    PTZ00107
    Location:23 → 464
    PTZ00107; hexokinase; Provisional
    pfam00349
    Location:473 → 671
    Hexokinase_1
    pfam03727
    Location:677 → 911
    Hexokinase_2
  3. XM_039098435.2 → XP_038954363.1  hexokinase-1 isoform X3

    UniProtKB/Swiss-Prot
    P05708
    UniProtKB/TrEMBL
    A0A8I6ARQ9
    Related
    ENSRNOP00000097394.1, ENSRNOT00000105408.2
    Conserved Domains (3) summary
    PTZ00107
    Location:18 → 459
    PTZ00107; hexokinase; Provisional
    pfam00349
    Location:468 → 666
    Hexokinase_1
    pfam03727
    Location:672 → 906
    Hexokinase_2
  4. XM_063278971.1 → XP_063135041.1  hexokinase-1 isoform X4

    UniProtKB/Swiss-Prot
    P05708
    Related
    ENSRNOP00000093592.2, ENSRNOT00000115199.2
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