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    Pde1c phosphodiesterase 1C [ Rattus norvegicus (Norway rat) ]

    Gene ID: 81742, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pde1cprovided by RGD
    Official Full Name
    phosphodiesterase 1Cprovided by RGD
    Primary source
    RGD:68332
    See related
    EnsemblRapid:ENSRNOG00000012337 AllianceGenome:RGD:68332
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables cAMP binding activity; calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity; and calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity. Involved in negative regulation of insulin secretion involved in cellular response to glucose stimulus. Acts upstream of or within response to calcium ion. Located in neuronal cell body. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 74. Orthologous to human PDE1C (phosphodiesterase 1C). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 43.5), Kidney (RPKM 40.2) and 8 other tissues See more
    Orthologs
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    Genomic context

    See Pde1c in Genome Data Viewer
    Location:
    4q24
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (86629074..87108147, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (85300858..85777948, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (86359762..86925044, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1, regulatory subunit 17 Neighboring gene uncharacterized LOC134486774 Neighboring gene apolipoprotein O, pseudogene 4 Neighboring gene transfer RNA serine (anticodon AGA) 44 Neighboring gene transfer RNA threonine (anticodon AGU) 9 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene small nucleolar RNA SNORA17

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 3',5'-cyclic-AMP phosphodiesterase activity  
    enables 3',5'-cyclic-AMP phosphodiesterase activity  
    enables 3',5'-cyclic-GMP phosphodiesterase activity  
    enables 3',5'-cyclic-GMP phosphodiesterase activity  
    enables 3',5'-cyclic-nucleotide phosphodiesterase activity  
    enables cAMP binding PubMed 
    enables calmodulin binding  
    enables calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity  
    enables calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity PubMed 
    enables calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity  
    enables calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity PubMed 
    enables calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity  
    enables calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity  
    enables metal ion binding  
    Component Evidence Code Pubs
    located_in cilium  
    located_in lysosome  
    located_in lysosome  
    is_active_in neuronal cell body  
    located_in neuronal cell body PubMed 

    General protein information

    Preferred Names
    dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C
    Names
    3',5'-cyclic-AMP phosphodiesterase
    3',5'-cyclic-GMP phosphodiesterase
    calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C
    cam-PDE 1C
    cyclic nucleotide phosphodiesterase 1 C
    dual specificity Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C
    phosphodiesterase 1C calmodulin-dependent (70kD)
    NP_112340.1
    XP_008761144.2
    XP_038964360.1
    XP_038964361.1
    XP_038964362.1
    XP_038964363.1
    XP_063142821.1
    XP_063142822.1
    XP_063142823.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031078.2NP_112340.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C

      See identical proteins and their annotated locations for NP_112340.1

      Status: PROVISIONAL

      Source sequence(s)
      L41045
      UniProtKB/Swiss-Prot
      Q63421
      UniProtKB/TrEMBL
      A0A8I6AQQ1, A6K104
      Related
      ENSRNOP00000096395.2, ENSRNOT00000098186.2
      Conserved Domains (2) summary
      pfam00233
      Location:287515
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08499
      Location:146202
      PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      86629074..87108147 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008762922.4XP_008761144.2  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X2

      UniProtKB/TrEMBL
      A0A8I5Y1F5, A6K105, F1LMX4
      Conserved Domains (3) summary
      PTZ00121
      Location:543635
      PTZ00121; MAEBL; Provisional
      pfam00233
      Location:227455
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08499
      Location:86142
      PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal
    2. XM_039108434.2XP_038964362.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X2

      UniProtKB/TrEMBL
      A0A8I5Y1F5, A6K105, F1LMX4
      Related
      ENSRNOP00000017531.8, ENSRNOT00000017531.9
      Conserved Domains (3) summary
      PTZ00121
      Location:543635
      PTZ00121; MAEBL; Provisional
      pfam00233
      Location:227455
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08499
      Location:86142
      PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal
    3. XM_039108433.2XP_038964361.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1

      UniProtKB/TrEMBL
      A0A8I6AQQ1, A6K104
      Conserved Domains (3) summary
      PTZ00121
      Location:603695
      PTZ00121; MAEBL; Provisional
      pfam00233
      Location:287515
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08499
      Location:146202
      PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal
    4. XM_039108432.2XP_038964360.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1

      UniProtKB/TrEMBL
      A0A8I6AQQ1, A6K104
      Related
      ENSRNOP00000099233.1, ENSRNOT00000146532.1
      Conserved Domains (3) summary
      PTZ00121
      Location:603695
      PTZ00121; MAEBL; Provisional
      pfam00233
      Location:287515
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08499
      Location:146202
      PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal
    5. XM_063286751.1XP_063142821.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X4

      UniProtKB/TrEMBL
      A0A8I5Y1F5, A0A8I6AMU0, A6K107
      Related
      ENSRNOP00000099194.1, ENSRNOT00000167670.1
    6. XM_039108435.2XP_038964363.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X3

      UniProtKB/TrEMBL
      A0A8I6A8V6, A0A8I6AQQ1, A6K104
      Related
      ENSRNOP00000089783.1, ENSRNOT00000118567.2
      Conserved Domains (3) summary
      PTZ00121
      Location:603690
      PTZ00121; MAEBL; Provisional
      pfam00233
      Location:287515
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08499
      Location:146202
      PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal
    7. XM_063286753.1XP_063142823.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X5

      UniProtKB/TrEMBL
      A0A8I5Y1F5, A6K108
      Related
      ENSRNOP00000077659.1, ENSRNOT00000098034.2
    8. XM_063286752.1XP_063142822.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X5

      UniProtKB/TrEMBL
      A0A8I5Y1F5, A6K108
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