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Gcnt2 glucosaminyl (N-acetyl) transferase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 306860, updated on 9-Dec-2024

Summary

Official Symbol
Gcnt2provided by RGD
Official Full Name
glucosaminyl (N-acetyl) transferase 2provided by RGD
Primary source
RGD:1303198
See related
EnsemblRapid:ENSRNOG00000023778 AllianceGenome:RGD:1303198
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ignt; Gcnt6
Summary
Predicted to enable N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity. Predicted to be involved in several processes, including maintenance of lens transparency; positive regulation of intracellular signal transduction; and transforming growth factor beta receptor signaling pathway. Predicted to be located in Golgi apparatus. Human ortholog(s) of this gene implicated in cataract and cataract 13 with adult i phenotype. Orthologous to human GCNT2 (glucosaminyl (N-acetyl) transferase 2 (I blood group)). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Lung (RPKM 53.1), Kidney (RPKM 49.9) and 9 other tissues See more
Orthologs
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Genomic context

See Gcnt2 in Genome Data Viewer
Location:
17p12
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (24002592..24107339, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (23796859..23901625, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (21634546..21677477, complement)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482840 Neighboring gene PAK1 interacting protein 1 Neighboring gene similar to human chromosome 6 open reading frame 52 Neighboring gene uncharacterized LOC103694058 Neighboring gene uncharacterized LOC120097872 Neighboring gene uncharacterized LOC120097871 Neighboring gene ribosomal protein L9-like Neighboring gene glucosaminyl (N-acetyl) transferase 2, pseudogene 1 Neighboring gene ribosomal protein L29, pseudogene 4

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Gene Ontology Provided by RGD

Component Evidence Code Pubs
located_in Golgi apparatus  
located_in Golgi membrane  

General protein information

Preferred Names
N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase
Names
I-branching beta-1,6-acetylglucosaminyltransferase
N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase-like
glucosaminyl (N-acetyl) transferase 2 (I blood group)
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme
glucosaminyl (N-acetyl) transferase 6
NP_001001511.1
NP_001387780.1
XP_038951614.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001511.4NP_001001511.1  N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase isoform 2

    See identical proteins and their annotated locations for NP_001001511.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000017
    UniProtKB/TrEMBL
    Q6T5D9
    Related
    ENSRNOP00000029151.3, ENSRNOT00000035448.6
    Conserved Domains (1) summary
    pfam02485
    Location:95356
    Branch; Core-2/I-Branching enzyme
  2. NM_001400851.1NP_001387780.1  N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000017
    UniProtKB/TrEMBL
    A0A0G2KAF0, Q6T5E0
    Related
    ENSRNOP00000075374.1, ENSRNOT00000078010.3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    24002592..24107339 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039095686.2XP_038951614.1  N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase isoform X1

    UniProtKB/TrEMBL
    F7FDB0, Q6T5E1
    Related
    ENSRNOP00000057083.3, ENSRNOT00000060335.5
    Conserved Domains (1) summary
    pfam02485
    Location:95356
    Branch; Core-2/I-Branching enzyme

RNA

  1. XR_005495276.2 RNA Sequence

  2. XR_005495275.2 RNA Sequence

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