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    Slc8a2 solute carrier family 8 member A2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 140447, updated on 9-Dec-2024

    Summary

    Official Symbol
    Slc8a2provided by RGD
    Official Full Name
    solute carrier family 8 member A2provided by RGD
    Primary source
    RGD:620194
    See related
    EnsemblRapid:ENSRNOG00000001492 AllianceGenome:RGD:620194
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ncx2
    Summary
    Enables calcium:monoatomic cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration and calcium:sodium antiporter activity. Involved in monoatomic cation transmembrane transport; response to vitamin D; and telencephalon development. Acts upstream of or within intracellular calcium ion homeostasis. Located in several cellular components, including dendritic spine; microtubule; and neuronal cell body. Is active in postsynaptic membrane. Biomarker of brain ischemia and status epilepticus. Orthologous to human SLC8A2 (solute carrier family 8 member A2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 340.5) and Uterus (RPKM 29.6) See more
    Orthologs
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    Genomic context

    See Slc8a2 in Genome Data Viewer
    Location:
    1q21
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (85944752..85982900)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (76816583..76852928)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (78029555..78054042)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene NSF attachment protein alpha Neighboring gene kaptin (actin binding protein) Neighboring gene Meis homeobox 3 Neighboring gene DExH-box helicase 34

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Items 1 - 25 of 56
    Process Evidence Code Pubs
    involved_in calcium ion export across plasma membrane PubMed 
    involved_in calcium ion export across plasma membrane  
    involved_in calcium ion export across plasma membrane  
    involved_in calcium ion homeostasis  
    involved_in calcium ion import across plasma membrane  
    involved_in calcium ion import across plasma membrane PubMed 
    involved_in calcium ion transmembrane transport PubMed 
    involved_in calcium ion transmembrane transport PubMed 
    involved_in calcium ion transmembrane transport  
    involved_in calcium ion transport  
    involved_in calcium ion transport into cytosol PubMed 
    involved_in cell communication  
    acts_upstream_of_or_within cognition  
    acts_upstream_of_or_within intracellular calcium ion homeostasis PubMed 
    acts_upstream_of_or_within intracellular calcium ion homeostasis PubMed 
    acts_upstream_of_or_within intracellular calcium ion homeostasis  
    involved_in intracellular calcium ion homeostasis  
    involved_in learning  
    involved_in learning  
    involved_in learning  
    acts_upstream_of_or_within learning or memory  
    involved_in long-term synaptic potentiation  
    acts_upstream_of_or_within long-term synaptic potentiation  
    involved_in long-term synaptic potentiation  
    involved_in long-term synaptic potentiation  
    involved_in memory  
    involved_in memory  
    involved_in memory  
    involved_in modulation of excitatory postsynaptic potential  
    acts_upstream_of_or_within modulation of excitatory postsynaptic potential  
    involved_in neuron cellular homeostasis  
    involved_in neuron cellular homeostasis  
    acts_upstream_of_or_within positive regulation of protein serine/threonine kinase activity  
    involved_in regulation of action potential firing pattern  
    acts_upstream_of_or_within regulation of action potential firing pattern  
    involved_in regulation of calcineurin-mediated signaling  
    acts_upstream_of regulation of calcineurin-mediated signaling  
    involved_in regulation of cytosolic calcium ion concentration  
    acts_upstream_of_or_within regulation of cytosolic calcium ion concentration  
    involved_in regulation of gene expression  
    acts_upstream_of_or_within regulation of gene expression  
    involved_in regulation of postsynaptic cytosolic calcium ion concentration  
    involved_in regulation of short-term neuronal synaptic plasticity  
    involved_in regulation of short-term neuronal synaptic plasticity  
    involved_in regulation of short-term neuronal synaptic plasticity  
    involved_in response to ischemia  
    acts_upstream_of_or_within response to ischemia  
    involved_in response to vitamin D PubMed 
    involved_in sodium ion transmembrane transport  
    involved_in sodium ion transmembrane transport PubMed 
    involved_in sodium ion transmembrane transport  
    involved_in sodium ion transmembrane transport  
    involved_in sodium ion transport PubMed 
    involved_in synapse organization  
    acts_upstream_of_or_within synapse organization  
    involved_in telencephalon development PubMed 
    Items 1 - 25 of 56
    Items 1 - 20 of 23
    Component Evidence Code Pubs
    is_active_in axon  
    located_in axon PubMed 
    located_in axon  
    located_in axon terminus  
    located_in axon terminus  
    located_in basolateral plasma membrane  
    located_in cell projection PubMed 
    located_in dendrite PubMed 
    located_in dendritic spine PubMed 
    located_in microtubule PubMed 
    located_in neuronal cell body PubMed 
    located_in perikaryon  
    located_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane  
    is_active_in postsynapse  
    located_in postsynapse  
    located_in postsynaptic density  
    located_in postsynaptic density  
    is_active_in postsynaptic membrane PubMed 
    located_in presynapse  
    is_active_in sarcolemma  
    located_in synapse  
    Items 1 - 20 of 23

    General protein information

    Preferred Names
    sodium/calcium exchanger 2
    Names
    Na(+)/Ca(2+)-exchange protein 2
    solute carrier family 8 (sodium/calcium exchanger), member 2
    solute carrier family 8 member 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_078619.2NP_511174.2  sodium/calcium exchanger 2 precursor

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      P48768
      UniProtKB/TrEMBL
      A0A0G2JZK7, A6J898
      Related
      ENSRNOP00000104936.1, ENSRNOT00000130528.1
      Conserved Domains (1) summary
      TIGR00845
      Location:1921
      caca; sodium/calcium exchanger 1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      85944752..85982900
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039080746.2XP_038936674.1  sodium/calcium exchanger 2 isoform X3

      UniProtKB/Swiss-Prot
      P48768
      Related
      ENSRNOP00000071086.3, ENSRNOT00000086396.3
      Conserved Domains (1) summary
      TIGR00845
      Location:1852
      caca; sodium/calcium exchanger 1
    2. XM_039080711.2XP_038936639.1  sodium/calcium exchanger 2 isoform X1

      UniProtKB/Swiss-Prot
      P48768
      UniProtKB/TrEMBL
      A0A0G2JZK7, A6J898
      Related
      ENSRNOP00000042012.7, ENSRNOT00000047289.7
      Conserved Domains (1) summary
      TIGR00845
      Location:1921
      caca; sodium/calcium exchanger 1
    3. XM_063270123.1XP_063126193.1  sodium/calcium exchanger 2 isoform X4

      UniProtKB/Swiss-Prot
      P48768
    4. XM_063270095.1XP_063126165.1  sodium/calcium exchanger 2 isoform X2

      UniProtKB/Swiss-Prot
      P48768
      UniProtKB/TrEMBL
      F1M9A2
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