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    Knstrn kinetochore-localized astrin/SPAG5 binding protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311325, updated on 9-Dec-2024

    Summary

    Official Symbol
    Knstrnprovided by RGD
    Official Full Name
    kinetochore-localized astrin/SPAG5 binding proteinprovided by RGD
    Primary source
    RGD:1303240
    See related
    EnsemblRapid:ENSRNOG00000009334 AllianceGenome:RGD:1303240
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    SKAP; C15orf23; Traf4af1
    Summary
    Predicted to enable microtubule plus-end binding activity and protein homodimerization activity. Predicted to be involved in several processes, including cellular response to epidermal growth factor stimulus; mitotic sister chromatid segregation; and regulation of attachment of spindle microtubules to kinetochore. Predicted to be located in microtubule organizing center; plasma membrane; and ruffle. Predicted to be active in kinetochore and microtubule cytoskeleton. Human ortholog(s) of this gene implicated in actinic keratosis and skin squamous cell carcinoma. Orthologous to human KNSTRN (kinetochore localized astrin (SPAG5) binding protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 194.0), Thymus (RPKM 109.1) and 8 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Knstrn in Genome Data Viewer
    Location:
    3q35
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (126254633..126274412)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (105800762..105820555)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (110618256..110638024)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene proline, histidine and glycine rich 1 Neighboring gene dispatched RND transporter family member 2 Neighboring gene isovaleryl-CoA dehydrogenase Neighboring gene uncharacterized LOC134486300

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Clone Names

    • MGC94986

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables microtubule plus-end binding  
    enables microtubule plus-end binding  
    enables protein homodimerization activity  
    enables protein homodimerization activity  
    Process Evidence Code Pubs
    involved_in cell division  
    involved_in cell migration  
    involved_in cell migration  
    involved_in cellular response to epidermal growth factor stimulus  
    involved_in cellular response to epidermal growth factor stimulus  
    involved_in chromosome segregation  
    involved_in chromosome segregation  
    involved_in microtubule cytoskeleton organization  
    involved_in mitotic sister chromatid segregation  
    involved_in mitotic sister chromatid segregation  
    involved_in mitotic sister chromatid segregation  
    involved_in mitotic sister chromatid segregation  
    involved_in regulation of attachment of spindle microtubules to kinetochore  
    involved_in regulation of attachment of spindle microtubules to kinetochore  
    involved_in regulation of attachment of spindle microtubules to kinetochore  
    involved_in regulation of attachment of spindle microtubules to kinetochore  
    involved_in spindle organization  
    involved_in spindle organization  
    involved_in spindle organization  
    involved_in spindle organization  
    Items 1 - 20 of 23
    Component Evidence Code Pubs
    is_active_in centriolar satellite  
    located_in centriolar satellite  
    located_in centriolar satellite  
    located_in cytoplasm  
    is_active_in kinetochore  
    located_in kinetochore  
    located_in kinetochore  
    located_in kinetochore  
    located_in microtubule organizing center  
    is_active_in microtubule plus-end  
    located_in microtubule plus-end  
    located_in microtubule plus-end  
    located_in microtubule plus-end  
    is_active_in mitotic spindle  
    located_in mitotic spindle  
    located_in mitotic spindle  
    located_in mitotic spindle  
    located_in nucleus  
    located_in plasma membrane  
    located_in plasma membrane  
    located_in ruffle  
    located_in ruffle  
    located_in spindle pole  
    Items 1 - 20 of 23

    General protein information

    Preferred Names
    small kinetochore-associated protein
    Names
    TRAF4-associated factor 1
    kinastrin
    kinetochore-localized astrin-binding protein
    putative TRAF4-associated factor 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004264.1NP_001004264.1  small kinetochore-associated protein

      See identical proteins and their annotated locations for NP_001004264.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079438
      UniProtKB/Swiss-Prot
      Q6AXN6
      Related
      ENSRNOP00000104011.1, ENSRNOT00000131514.1
      Conserved Domains (1) summary
      cl17190
      Location:115192
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      126254633..126274412
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063283710.1XP_063139780.1  small kinetochore-associated protein isoform X3

    2. XM_006234757.5XP_006234819.1  small kinetochore-associated protein isoform X1

      Related
      ENSRNOP00000012454.6, ENSRNOT00000012454.7
      Conserved Domains (1) summary
      cl17190
      Location:115192
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
    3. XM_006234758.5XP_006234820.1  small kinetochore-associated protein isoform X2

      UniProtKB/TrEMBL
      A0A8L2Q5L7
      Conserved Domains (1) summary
      cl17190
      Location:57134
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
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