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Birc5 baculoviral IAP repeat-containing 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 64041, updated on 9-Dec-2024

Summary

Official Symbol
Birc5provided by RGD
Official Full Name
baculoviral IAP repeat-containing 5provided by RGD
Primary source
RGD:70499
See related
EnsemblRapid:ENSRNOG00000050819 AllianceGenome:RGD:70499
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
AP14
Summary
Predicted to enable several functions, including cysteine-type endopeptidase inhibitor activity involved in apoptotic process; protein dimerization activity; and small GTPase binding activity. Involved in several processes, including cellular response to ethanol; cellular response to stem cell factor stimulus; and response to glucocorticoid. Located in apical plasma membrane. Used to study endometriosis and pulmonary hypertension. Biomarker of acute pancreatitis (multiple); artery disease (multiple); congestive heart failure; high grade glioma; and stomach carcinoma. Human ortholog(s) of this gene implicated in prostate cancer and transitional cell carcinoma. Orthologous to human BIRC5 (baculoviral IAP repeat containing 5). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Thymus (RPKM 156.5), Spleen (RPKM 102.8) and 9 other tissues See more
Orthologs
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Genomic context

See Birc5 in Genome Data Viewer
Location:
10q32.2
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (103567369..103580069)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (103072530..103081382)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (106856097..106864419)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene thymidine kinase 1 Neighboring gene arylformamidase Neighboring gene uncharacterized LOC102548046 Neighboring gene transmembrane protein 235 Neighboring gene threonine aldolase 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cysteine-type endopeptidase inhibitor activity  
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process  
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process  
enables enzyme binding  
enables identical protein binding  
enables microtubule binding  
enables microtubule binding  
enables protein heterodimerization activity  
enables protein homodimerization activity  
enables protein homodimerization activity  
enables protein-folding chaperone binding  
enables small GTPase binding  
enables tubulin binding  
enables tubulin binding  
enables zinc ion binding  
enables zinc ion binding  
Items 1 - 25 of 52
Process Evidence Code Pubs
involved_in G2/M transition of mitotic cell cycle  
involved_in G2/M transition of mitotic cell cycle  
involved_in apoptotic process  
involved_in cell division  
involved_in cell division  
involved_in cell division  
involved_in cellular response to ethanol PubMed 
involved_in cellular response to stem cell factor stimulus PubMed 
involved_in chromosome segregation  
involved_in chromosome segregation  
involved_in establishment of chromosome localization  
involved_in establishment of chromosome localization  
involved_in meiosis I  
involved_in meiosis I  
involved_in microtubule cytoskeleton organization  
acts_upstream_of_or_within microtubule cytoskeleton organization  
involved_in mitotic cytokinesis  
involved_in mitotic cytokinesis  
involved_in mitotic cytokinesis  
involved_in mitotic spindle assembly checkpoint signaling  
involved_in mitotic spindle assembly checkpoint signaling  
involved_in mitotic spindle organization  
involved_in negative regulation of DNA-templated transcription  
involved_in negative regulation of DNA-templated transcription  
involved_in negative regulation of apoptotic process  
involved_in negative regulation of apoptotic process PubMed 
acts_upstream_of_or_within negative regulation of apoptotic process  
involved_in negative regulation of apoptotic process  
involved_in negative regulation of apoptotic process  
involved_in negative regulation of cysteine-type endopeptidase activity  
involved_in negative regulation of cysteine-type endopeptidase activity  
involved_in negative regulation of neuron apoptotic process  
acts_upstream_of_or_within negative regulation of neuron apoptotic process  
involved_in positive regulation of cell cycle PubMed 
involved_in positive regulation of exit from mitosis  
involved_in positive regulation of exit from mitosis  
involved_in positive regulation of mitotic cell cycle  
involved_in positive regulation of mitotic cell cycle  
involved_in protein phosphorylation  
involved_in protein phosphorylation  
involved_in protein-containing complex localization  
involved_in protein-containing complex localization  
involved_in regulation of insulin secretion involved in cellular response to glucose stimulus  
acts_upstream_of_or_within regulation of insulin secretion involved in cellular response to glucose stimulus  
involved_in regulation of mitotic cell cycle  
acts_upstream_of_or_within regulation of mitotic cell cycle  
involved_in regulation of type B pancreatic cell proliferation  
acts_upstream_of_or_within regulation of type B pancreatic cell proliferation  
involved_in response to glucocorticoid PubMed 
involved_in response to peptide hormone PubMed 
involved_in response to xenobiotic stimulus PubMed 
involved_in sensory perception of sound  
Items 1 - 25 of 52
Items 1 - 20 of 36
Component Evidence Code Pubs
located_in apical plasma membrane PubMed 
located_in centriole  
located_in centriole  
part_of chromosome passenger complex  
part_of chromosome passenger complex  
part_of chromosome passenger complex  
is_active_in chromosome, centromeric region  
located_in chromosome, centromeric region  
located_in chromosome, centromeric region  
is_active_in cytoplasm  
located_in cytoplasm  
located_in cytoplasm  
located_in cytoplasm  
located_in cytoplasmic microtubule  
located_in cytoplasmic microtubule  
located_in cytosol  
located_in cytosol  
located_in interphase microtubule organizing center  
located_in interphase microtubule organizing center  
is_active_in kinetochore  
located_in kinetochore  
located_in kinetochore  
located_in kinetochore  
located_in microtubule cytoskeleton  
located_in midbody  
located_in midbody  
located_in midbody  
located_in nuclear chromosome  
located_in nucleus  
located_in nucleus  
part_of protein-containing complex  
located_in spindle  
located_in spindle microtubule  
located_in spindle microtubule  
is_active_in spindle midzone  
part_of survivin complex  
Items 1 - 20 of 36

General protein information

Preferred Names
baculoviral IAP repeat-containing protein 5
Names
apoptosis inhibitor survivin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022274.2 → NP_071610.2  baculoviral IAP repeat-containing protein 5

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/Swiss-Prot
    Q9JHY7
    UniProtKB/TrEMBL
    A6HL35
    Conserved Domains (1) summary
    pfam00653
    Location:18 → 88
    BIR; Inhibitor of Apoptosis domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    103567369..103580069
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063269805.1 → XP_063125875.1  baculoviral IAP repeat-containing protein 5 isoform X1

    UniProtKB/Swiss-Prot
    Q9JHY7
    UniProtKB/TrEMBL
    M0R8I8
    Related
    ENSRNOP00000065784.2, ENSRNOT00000072387.3
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