U.S. flag

An official website of the United States government

Med15 mediator complex subunit 15 [ Rattus norvegicus (Norway rat) ]

Gene ID: 360743, updated on 9-Dec-2024

Summary

Official Symbol
Med15provided by RGD
Official Full Name
mediator complex subunit 15provided by RGD
Primary source
RGD:1307560
See related
EnsemblRapid:ENSRNOG00000001877 AllianceGenome:RGD:1307560
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Pcqap
Summary
Predicted to enable transcription coregulator activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to act upstream of or within somatic stem cell population maintenance. Predicted to be located in nucleoplasm. Predicted to be part of core mediator complex. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human MED15 (mediator complex subunit 15). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Thymus (RPKM 97.8), Spleen (RPKM 95.3) and 9 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Med15 in Genome Data Viewer
Location:
11q23
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (96784974..96859635)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (83280722..83356006)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (87553868..87628631, complement)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene kelch-like family member 22 Neighboring gene large ribosomal subunit protein eL31-like Neighboring gene ribosomal protein S15, pseudogene 13 Neighboring gene ribosomal protein L34, pseudogene 2 Neighboring gene U6 spliceosomal RNA Neighboring gene coiled-coil domain containing 74A

Genomic regions, transcripts, and products

General gene information

Gene Ontology Provided by RGD

Component Evidence Code Pubs
part_of core mediator complex  
part_of core mediator complex  
located_in nucleoplasm  
located_in nucleoplasm  
located_in nucleus  

General protein information

Preferred Names
mediator of RNA polymerase II transcription subunit 15
Names
positive cofactor 2, multiprotein complex, glutamine/Q-rich-associated protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108325.1NP_001101795.1  mediator of RNA polymerase II transcription subunit 15

    See identical proteins and their annotated locations for NP_001101795.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473999
    UniProtKB/TrEMBL
    A0A8I5ZVE0, A6JSK4, G3V684
    Related
    ENSRNOP00000002568.5, ENSRNOT00000002568.7
    Conserved Domains (1) summary
    pfam09606
    Location:17786
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    96784974..96859635
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039088530.2XP_038944458.1  mediator of RNA polymerase II transcription subunit 15 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZVE0
    Related
    ENSRNOP00000099696.1, ENSRNOT00000132602.1
    Conserved Domains (1) summary
    pfam09606
    Location:17715
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
  2. XM_006248702.5XP_006248764.1  mediator of RNA polymerase II transcription subunit 15 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A373, A0A8I6GJV4
    Related
    ENSRNOP00000085424.1, ENSRNOT00000117596.2
    Conserved Domains (1) summary
    pfam09606
    Location:17746
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
  3. XM_063270660.1XP_063126730.1  mediator of RNA polymerase II transcription subunit 15 isoform X7

  4. XM_063270659.1XP_063126729.1  mediator of RNA polymerase II transcription subunit 15 isoform X6

  5. XM_006248706.5XP_006248768.1  mediator of RNA polymerase II transcription subunit 15 isoform X8

    UniProtKB/TrEMBL
    A0A8I5ZVE0
    Conserved Domains (1) summary
    pfam09606
    Location:17763
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
  6. XM_039088531.2XP_038944459.1  mediator of RNA polymerase II transcription subunit 15 isoform X3

    UniProtKB/TrEMBL
    A0A8I6GJV4
    Related
    ENSRNOP00000099727.1, ENSRNOT00000152972.1
    Conserved Domains (1) summary
    pfam09606
    Location:17703
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
  7. XM_039088532.2XP_038944460.1  mediator of RNA polymerase II transcription subunit 15 isoform X4

    UniProtKB/TrEMBL
    A0A8I5ZVE0
    Conserved Domains (1) summary
    pfam09606
    Location:17675
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
  8. XM_039088533.2XP_038944461.1  mediator of RNA polymerase II transcription subunit 15 isoform X5

    UniProtKB/TrEMBL
    A0A8I6GJV4
    Conserved Domains (1) summary
    pfam09606
    Location:344632
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
External link. Please review our privacy policy.