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    Mocos molybdenum cofactor sulfurase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361300, updated on 9-Dec-2024

    Summary

    Official Symbol
    Mocosprovided by RGD
    Official Full Name
    molybdenum cofactor sulfuraseprovided by RGD
    Primary source
    RGD:1308496
    See related
    EnsemblRapid:ENSRNOG00000015113 AllianceGenome:RGD:1308496
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable molybdenum cofactor sulfurtransferase activity. Predicted to be involved in molybdopterin cofactor biosynthetic process. Human ortholog(s) of this gene implicated in xanthinuria type II. Orthologous to human MOCOS (molybdenum cofactor sulfurase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 48.3), Lung (RPKM 38.3) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Mocos in Genome Data Viewer
    Location:
    18p12
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (16206402..16251928)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (15931659..15977415)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (16590086..16636312)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 39 member 6 Neighboring gene elongator acetyltransferase complex subunit 2 Neighboring gene formin homology 2 domain containing 3 Neighboring gene uncharacterized LOC120098112 Neighboring gene heat shock cognate protein 70, pseudogene 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables lyase activity  
    enables molybdenum cofactor sulfurtransferase activity  
    enables molybdenum cofactor sulfurtransferase activity  
    enables molybdenum ion binding  
    enables pyridoxal phosphate binding  

    General protein information

    Preferred Names
    molybdenum cofactor sulfurase
    NP_001382600.1
    XP_017456477.1
    XP_063133533.1
    XP_063133534.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395671.1NP_001382600.1  molybdenum cofactor sulfurase

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/TrEMBL
      A0A1W2Q693, A6J2K9
      Related
      ENSRNOP00000076171.1, ENSRNOT00000093715.3
      Conserved Domains (1) summary
      PLN02724
      Location:28854
      PLN02724; Molybdenum cofactor sulfurase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      16206402..16251928
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063277464.1XP_063133534.1  molybdenum cofactor sulfurase isoform X2

    2. XM_063277463.1XP_063133533.1  molybdenum cofactor sulfurase isoform X1

      Related
      ENSRNOP00000100317.1, ENSRNOT00000129170.1
    3. XM_017600988.3XP_017456477.1  molybdenum cofactor sulfurase isoform X3

    RNA

    1. XR_001842027.3 RNA Sequence

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