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    Arhgap28 Rho GTPase activating protein 28 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 301709, updated on 9-Dec-2024

    Summary

    Official Symbol
    Arhgap28provided by RGD
    Official Full Name
    Rho GTPase activating protein 28provided by RGD
    Primary source
    RGD:1559882
    See related
    EnsemblRapid:ENSRNOG00000017065 AllianceGenome:RGD:1559882
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1559882
    Summary
    Predicted to enable GTPase activator activity. Predicted to be involved in negative regulation of stress fiber assembly; regulation of actin filament polymerization; and regulation of small GTPase mediated signal transduction. Predicted to be located in cell junction and nucleoplasm. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in allergic disease. Orthologous to human ARHGAP28 (Rho GTPase activating protein 28). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 72.8), Lung (RPKM 46.5) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Arhgap28 in Genome Data Viewer
    Location:
    9q38
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (115277849..115444789, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (107832584..107998030, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (116057229..116222440, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 30 Neighboring gene laminin subunit alpha 1 Neighboring gene uncharacterized LOC120094776 Neighboring gene uncharacterized LOC134480307 Neighboring gene ribosomal protein S26, pseudogene 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase activator activity  
    Component Evidence Code Pubs
    located_in cell junction  
    located_in cell junction  
    is_active_in cytoplasm  
    located_in nucleoplasm  
    located_in nucleoplasm  

    General protein information

    Preferred Names
    rho GTPase-activating protein 28

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191815.1NP_001178744.1  rho GTPase-activating protein 28

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      F1M332
      Related
      ENSRNOP00000063588.5, ENSRNOT00000067900.5
      Conserved Domains (1) summary
      cd04391
      Location:378589
      RhoGAP_ARHGAP18; RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      115277849..115444789 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039083430.2XP_038939358.1  rho GTPase-activating protein 28 isoform X1

      Conserved Domains (1) summary
      cd04391
      Location:378588
      RhoGAP_ARHGAP18; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but ...
    2. XM_006245626.5XP_006245688.1  rho GTPase-activating protein 28 isoform X2

      UniProtKB/TrEMBL
      A0A0G2JWW2
      Related
      ENSRNOP00000070038.2, ENSRNOT00000090111.3
      Conserved Domains (1) summary
      cd04391
      Location:360571
      RhoGAP_ARHGAP18; RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their ...
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