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Map4k3 mitogen-activated protein kinase kinase kinase kinase 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 170920, updated on 9-Dec-2024

Summary

Official Symbol
Map4k3provided by RGD
Official Full Name
mitogen-activated protein kinase kinase kinase kinase 3provided by RGD
Primary source
RGD:621280
See related
EnsemblRapid:ENSRNOG00000007172 AllianceGenome:RGD:621280
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables SH3 domain binding activity. Predicted to be involved in several processes, including protein phosphorylation; response to UV; and response to tumor necrosis factor. Predicted to be active in cytoplasm. Orthologous to human MAP4K3 (mitogen-activated protein kinase kinase kinase kinase 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Kidney (RPKM 225.0), Lung (RPKM 194.0) and 9 other tissues See more
Orthologs
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Genomic context

See Map4k3 in Genome Data Viewer
Location:
6q12
Exon count:
38
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (20029246..20198583)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (14276623..14446321)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (3276732..3444519, complement)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479322 Neighboring gene uncharacterized LOC102551891 Neighboring gene eukaryotic translation initiation factor 1-like Neighboring gene cyclin-dependent kinase-like 4 Neighboring gene Rho guanine nucleotide exchange factor 33 Neighboring gene SOS Ras/Rac guanine nucleotide exchange factor 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by RGD

Items 1 - 25 of 29
Function Evidence Code Pubs
enables 3-phosphoinositide-dependent protein kinase activity  
enables AMP-activated protein kinase activity  
enables ATP binding  
enables ATP binding  
enables ATP binding  
enables DNA-dependent protein kinase activity  
enables MAP kinase kinase kinase kinase activity  
enables MAP kinase kinase kinase kinase activity  
enables Rho-dependent protein serine/threonine kinase activity  
enables SH3 domain binding PubMed 
enables eukaryotic translation initiation factor 2alpha kinase activity  
enables histone H2AS1 kinase activity  
enables histone H2AS121 kinase activity  
enables histone H2AT120 kinase activity  
enables histone H2AXS139 kinase activity  
enables histone H2BS14 kinase activity  
enables histone H2BS36 kinase activity  
enables histone H3S10 kinase activity  
enables histone H3S28 kinase activity  
enables histone H3S57 kinase activity  
enables histone H3T11 kinase activity  
enables histone H3T3 kinase activity  
enables histone H3T45 kinase activity  
enables histone H3T6 kinase activity  
enables histone H4S1 kinase activity  
enables protein serine kinase activity  
enables protein serine/threonine kinase activity  
enables protein serine/threonine kinase activity  
enables ribosomal protein S6 kinase activity  
Items 1 - 25 of 29
Process Evidence Code Pubs
involved_in MAPK cascade  
involved_in chromatin remodeling  
involved_in intracellular signal transduction  
involved_in intracellular signal transduction  
involved_in intracellular signal transduction  
involved_in protein phosphorylation  
involved_in protein phosphorylation  
involved_in response to UV  
involved_in response to UV  
involved_in response to UV  
involved_in response to tumor necrosis factor  
involved_in response to tumor necrosis factor  
Component Evidence Code Pubs
is_active_in cytoplasm  

General protein information

Preferred Names
mitogen-activated protein kinase kinase kinase kinase 3
Names
GLK
MAPK/ERK kinase kinase kinase 3
MEK kinase kinase 3
MEKKK 3
germinal center kinase-related protein kinase
NP_596898.1
XP_006239718.2
XP_017449508.2
XP_017449509.2
XP_017449510.2
XP_038967654.1
XP_038967655.1
XP_038967656.1
XP_038967657.1
XP_038967658.1
XP_038967659.1
XP_038967660.1
XP_038967661.1
XP_063117574.1
XP_063117575.1
XP_063117576.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133407.1NP_596898.1  mitogen-activated protein kinase kinase kinase kinase 3

    See identical proteins and their annotated locations for NP_596898.1

    Status: VALIDATED

    Source sequence(s)
    AA819812, AF312224, AI502900, CK474868, DV716943
    UniProtKB/Swiss-Prot
    Q924I2
    UniProtKB/TrEMBL
    A6H9Q1, R9PXT4
    Conserved Domains (3) summary
    smart00036
    Location:540853
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:16273
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06613
    Location:15273
    STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    20029246..20198583
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039111726.2XP_038967654.1  mitogen-activated protein kinase kinase kinase kinase 3 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AV17
    Conserved Domains (2) summary
    smart00036
    Location:583926
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cd06613
    Location:15273
    STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases
  2. XM_039111728.2XP_038967656.1  mitogen-activated protein kinase kinase kinase kinase 3 isoform X4

    UniProtKB/TrEMBL
    R9PXT4
    Conserved Domains (2) summary
    smart00036
    Location:562905
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cd06613
    Location:15273
    STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases
  3. XM_039111729.2XP_038967657.1  mitogen-activated protein kinase kinase kinase kinase 3 isoform X6

    UniProtKB/TrEMBL
    A0A8I6AV17
    Conserved Domains (2) summary
    smart00036
    Location:583896
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cd06613
    Location:15273
    STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases
  4. XM_039111727.2XP_038967655.1  mitogen-activated protein kinase kinase kinase kinase 3 isoform X3

    UniProtKB/TrEMBL
    A0A8I6AV17
    Conserved Domains (2) summary
    smart00036
    Location:572915
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cd06613
    Location:15273
    STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases
  5. XM_017594019.3XP_017449508.2  mitogen-activated protein kinase kinase kinase kinase 3 isoform X2

    UniProtKB/TrEMBL
    A0A8I6AV17
    Conserved Domains (2) summary
    smart00036
    Location:572915
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cd06613
    Location:15273
    STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases
  6. XM_017594021.3XP_017449510.2  mitogen-activated protein kinase kinase kinase kinase 3 isoform X7

    UniProtKB/TrEMBL
    R9PXT4
    Conserved Domains (2) summary
    smart00036
    Location:551894
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cd06613
    Location:15273
    STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases
  7. XM_017594020.3XP_017449509.2  mitogen-activated protein kinase kinase kinase kinase 3 isoform X5

    UniProtKB/TrEMBL
    A0A8I6AV17
    Related
    ENSRNOP00000090754.2, ENSRNOT00000110847.2
    Conserved Domains (2) summary
    smart00036
    Location:561904
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cd06613
    Location:15273
    STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases
  8. XM_063261505.1XP_063117575.1  mitogen-activated protein kinase kinase kinase kinase 3 isoform X9

    UniProtKB/TrEMBL
    R9PXT4
    Related
    ENSRNOP00000010366.8, ENSRNOT00000010366.9
  9. XM_063261504.1XP_063117574.1  mitogen-activated protein kinase kinase kinase kinase 3 isoform X8

    UniProtKB/TrEMBL
    A0A8I6AV17
    Related
    ENSRNOP00000069683.3, ENSRNOT00000084602.3
  10. XM_006239656.5XP_006239718.2  mitogen-activated protein kinase kinase kinase kinase 3 isoform X10

    UniProtKB/TrEMBL
    A0A0G2JVZ8, A0A8I6AV17
    Related
    ENSRNOP00000097492.1, ENSRNOT00000118971.2
    Conserved Domains (2) summary
    smart00036
    Location:561874
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cd06613
    Location:15273
    STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases
  11. XM_039111730.2XP_038967658.1  mitogen-activated protein kinase kinase kinase kinase 3 isoform X11

    UniProtKB/TrEMBL
    R9PXT4
    Conserved Domains (2) summary
    smart00036
    Location:551864
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cd06613
    Location:15273
    STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases
  12. XM_039111731.2XP_038967659.1  mitogen-activated protein kinase kinase kinase kinase 3 isoform X12

    UniProtKB/TrEMBL
    A0A0G2JYP2
    Conserved Domains (2) summary
    smart00036
    Location:520863
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cd06613
    Location:1210
    STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases
  13. XM_039111732.1XP_038967660.1  mitogen-activated protein kinase kinase kinase kinase 3 isoform X14

    UniProtKB/TrEMBL
    A0A0G2JYP2
    Conserved Domains (2) summary
    smart00036
    Location:494837
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:1184
    PKc_like; Protein Kinases, catalytic domain
  14. XM_063261506.1XP_063117576.1  mitogen-activated protein kinase kinase kinase kinase 3 isoform X13

    UniProtKB/TrEMBL
    A0A0G2JYP2
  15. XM_039111733.2XP_038967661.1  mitogen-activated protein kinase kinase kinase kinase 3 isoform X15

    UniProtKB/TrEMBL
    A0A0G2JYP2
    Conserved Domains (2) summary
    smart00036
    Location:406749
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:196
    PKc_like; Protein Kinases, catalytic domain
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