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    Srsf3 serine and arginine rich splicing factor 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361814, updated on 9-Dec-2024

    Summary

    Official Symbol
    Srsf3provided by RGD
    Official Full Name
    serine and arginine rich splicing factor 3provided by RGD
    Primary source
    RGD:1309233
    See related
    EnsemblRapid:ENSRNOG00000000520 AllianceGenome:RGD:1309233
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Sfrs3
    Summary
    Enables sequence-specific mRNA binding activity. Predicted to be involved in mRNA export from nucleus; primary miRNA processing; and regulation of mRNA splicing, via spliceosome. Predicted to act upstream of or within cellular response to leukemia inhibitory factor. Predicted to be located in nucleus. Predicted to be active in nuclear speck. Orthologous to human SRSF3 (serine and arginine rich splicing factor 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 933.5), Spleen (RPKM 600.8) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Srsf3 in Genome Data Viewer
    Location:
    20p12
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (7093529..7103517)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (7091928..7101860)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (6288285..6298218)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene serine/threonine kinase 38 Neighboring gene uncharacterized LOC134483866 Neighboring gene small Cajal body-specific RNA 14 like 1 Neighboring gene uncharacterized LOC120098812

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding  
    enables mRNA binding  
    enables phospholipase binding  
    NOT enables pre-mRNA binding  
    enables primary miRNA binding  
    enables protein-RNA sequence-specific adaptor activity  
    enables sequence-specific mRNA binding PubMed 
    Process Evidence Code Pubs
    involved_in RNA splicing  
    involved_in biological_process  
    acts_upstream_of_or_within cellular response to leukemia inhibitory factor  
    involved_in mRNA cis splicing, via spliceosome  
    involved_in mRNA export from nucleus  
    involved_in mRNA processing  
    involved_in primary miRNA processing  
    involved_in regulation of mRNA splicing, via spliceosome  
    Component Evidence Code Pubs
    is_active_in nuclear speck  
    is_active_in nuclear speck  
    located_in nuclear speck  

    General protein information

    Preferred Names
    serine/arginine-rich splicing factor 3
    Names
    splicing factor, arginine/serine-rich 3 (SRp20)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001047907.4NP_001041372.1  serine/arginine-rich splicing factor 3

      See identical proteins and their annotated locations for NP_001041372.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000020
      UniProtKB/TrEMBL
      Q0ZFS8
      Related
      ENSRNOP00000085609.2, ENSRNOT00000117194.2
      Conserved Domains (1) summary
      cd12645
      Location:686
      RRM_SRSF3; RNA recognition motif (RRM) found in vertebrate serine/arginine-rich splicing factor 3 (SRSF3)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      7093529..7103517
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063279228.1XP_063135298.1  serine/arginine-rich splicing factor 3 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZSN8, A0A8I6A2L6, A6JJT3
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