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Lrrn4 leucine rich repeat neuronal 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 311443, updated on 9-Dec-2024

Summary

Official Symbol
Lrrn4provided by RGD
Official Full Name
leucine rich repeat neuronal 4provided by RGD
Primary source
RGD:1305256
See related
EnsemblRapid:ENSRNOG00000032989 AllianceGenome:RGD:1305256
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1305256
Summary
Predicted to be involved in long-term memory. Predicted to act upstream of or within visual learning. Predicted to be active in plasma membrane. Orthologous to human LRRN4 (leucine rich repeat neuronal 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Lung (RPKM 57.1), Adrenal (RPKM 47.5) and 9 other tissues See more
Orthologs
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Genomic context

See Lrrn4 in Genome Data Viewer
Location:
3q36
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (140592303..140603986, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (120138093..120150877, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (125521879..125547685, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene minichromosome maintenance 8 homologous recombination repair factor Neighboring gene cardiolipin synthase 1 Neighboring gene FERM domain containing kindlin 1 Neighboring gene zinc finger and SCAN domain containing 5B, pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in long-term memory  
acts_upstream_of_or_within long-term memory  
acts_upstream_of_or_within visual learning  
Component Evidence Code Pubs
is_active_in plasma membrane  
located_in plasma membrane  

General protein information

Preferred Names
leucine-rich repeat neuronal protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001430451.1NP_001417380.1  leucine-rich repeat neuronal protein 4 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    F1LTX4

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    140592303..140603986 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_230550.11XP_230550.4  leucine-rich repeat neuronal protein 4

    Related
    ENSRNOP00000048191.4, ENSRNOT00000040802.7
    Conserved Domains (5) summary
    cd00063
    Location:580661
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00116
    Location:163296
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00031
    Location:305317
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:6483
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:177238
    LRR_8; Leucine rich repeat
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