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Arl3 ARF like GTPase 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 64664, updated on 9-Dec-2024

Summary

Official Symbol
Arl3provided by RGD
Official Full Name
ARF like GTPase 3provided by RGD
Primary source
RGD:69327
See related
EnsemblRapid:ENSRNOG00000019973 AllianceGenome:RGD:69327
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables GDP binding activity and GTP binding activity. Predicted to be involved in several processes, including Golgi to plasma membrane transport; protein localization to ciliary membrane; and small GTPase-mediated signal transduction. Predicted to act upstream of or within intraciliary transport; post-Golgi vesicle-mediated transport; and smoothened signaling pathway. Predicted to be located in several cellular components, including cytoskeleton; midbody; and photoreceptor connecting cilium. Predicted to be active in cytoplasm and microtubule cytoskeleton. Human ortholog(s) of this gene implicated in Joubert syndrome and retinitis pigmentosa 83. Orthologous to human ARL3 (ADP ribosylation factor like GTPase 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Brain (RPKM 191.5), Kidney (RPKM 151.1) and 9 other tissues See more
Orthologs
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Genomic context

See Arl3 in Genome Data Viewer
Location:
1q54
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (255342078..255388087, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (245400659..245446673, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (266287015..266333099, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene SUFU negative regulator of hedgehog signaling Neighboring gene uncharacterized LOC134484077 Neighboring gene tripartite motif-containing 8 Neighboring gene transfer RNA histidin (anticodon AUG) Neighboring gene sideroflexin 2 Neighboring gene WW domain binding protein 1-like Neighboring gene uncharacterized LOC120100047

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GDP binding PubMed 
enables GDP binding  
enables GDP binding  
enables GTP binding  
enables GTP binding PubMed 
enables GTP binding  
enables GTP binding  
enables GTPase activity  
enables GTPase activity  
enables magnesium ion binding  
enables magnesium ion binding  
enables microtubule binding  
enables microtubule binding  
enables microtubule binding  
Items 1 - 25 of 30
Process Evidence Code Pubs
involved_in Golgi to plasma membrane transport  
involved_in Golgi to plasma membrane transport  
involved_in Golgi to plasma membrane transport  
involved_in cell division  
involved_in cilium assembly  
involved_in cilium assembly  
involved_in cilium assembly  
involved_in cilium assembly  
involved_in intraciliary transport  
acts_upstream_of_or_within intraciliary transport  
involved_in kidney development  
involved_in kidney development  
involved_in kidney development  
involved_in mitotic cytokinesis  
involved_in mitotic cytokinesis  
involved_in mitotic cytokinesis  
involved_in photoreceptor cell development  
involved_in photoreceptor cell development  
involved_in photoreceptor cell development  
acts_upstream_of_or_within post-Golgi vesicle-mediated transport  
involved_in protein localization to ciliary membrane  
involved_in protein localization to ciliary membrane  
involved_in protein localization to ciliary membrane  
involved_in protein localization to cilium  
involved_in protein transport  
involved_in small GTPase-mediated signal transduction  
involved_in small GTPase-mediated signal transduction  
involved_in small GTPase-mediated signal transduction  
involved_in smoothened signaling pathway  
acts_upstream_of_or_within smoothened signaling pathway  
Items 1 - 25 of 30
Items 1 - 20 of 35
Component Evidence Code Pubs
located_in Golgi apparatus  
located_in Golgi apparatus  
located_in Golgi membrane  
located_in axoneme  
located_in axoneme  
located_in centrosome  
located_in centrosome  
located_in centrosome  
located_in ciliary basal body  
located_in ciliary basal body  
located_in ciliary transition zone  
located_in cilium  
NOT located_in cilium  
located_in cilium  
located_in cilium  
is_active_in cytoplasm  
located_in cytoplasmic microtubule  
located_in cytoplasmic microtubule  
located_in cytoplasmic microtubule  
is_active_in microtubule cytoskeleton  
located_in midbody  
located_in midbody  
located_in midbody  
located_in nucleoplasm  
located_in nucleoplasm  
located_in nucleus  
located_in nucleus  
located_in nucleus  
located_in photoreceptor connecting cilium  
located_in photoreceptor connecting cilium  
located_in photoreceptor connecting cilium  
located_in spindle  
located_in spindle microtubule  
located_in spindle microtubule  
located_in spindle microtubule  
Items 1 - 20 of 35

General protein information

Preferred Names
ADP-ribosylation factor-like protein 3
Names
ADP ribosylation factor like GTPase 3
ADP-ribosylation factor-like 3
ADP-ribosylation-like 3
ARD3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022700.2NP_073191.1  ADP-ribosylation factor-like protein 3

    See identical proteins and their annotated locations for NP_073191.1

    Status: PROVISIONAL

    Source sequence(s)
    BC084722
    UniProtKB/Swiss-Prot
    P37996
    UniProtKB/TrEMBL
    A0A8I6A6P9, A6JHM9
    Related
    ENSRNOP00000093371.1, ENSRNOT00000118411.2
    Conserved Domains (2) summary
    smart00178
    Location:15177
    SAR; Sar1p-like members of the Ras-family of small GTPases
    cd04155
    Location:3176
    Arl3; Arf-like 3 (Arl3) GTPase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    255342078..255388087 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006231559.5XP_006231621.1  ADP-ribosylation factor-like protein 3 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A6P9, F8WG91
    Related
    ENSRNOP00000100902.1, ENSRNOT00000159257.1
    Conserved Domains (1) summary
    cd04155
    Location:7180
    Arl3; Arf-like 3 (Arl3) GTPase
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