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Nat2 N-acetyltransferase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 116632, updated on 9-Dec-2024

Summary

Official Symbol
Nat2provided by RGD
Official Full Name
N-acetyltransferase 2provided by RGD
Primary source
RGD:70492
See related
EnsemblRapid:ENSRNOG00000029977 AllianceGenome:RGD:70492
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Nat2a
Summary
Enables arylamine N-acetyltransferase activity. Involved in several processes, including digestive tract development; response to hypoxia; and response to lipopolysaccharide. Predicted to be located in cytoplasm. Biomarker of end stage renal disease. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); contact dermatitis (multiple); leukemia (multiple); and lung disease (multiple). Orthologous to several human genes including NAT1 (N-acetyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
Annotation information
Note: Loci in other organisms that are functionally homologous to this one are validly referred to as both NAT1 and NAT2; i.e., the functional homologs of NAT1 include mouse and rat Nat2, while the functional homologs of human NAT2 include mouse and rat Nat1. Name:sequence associations are consistent with current use in the field. [13 Feb 2013]
Expression
Biased expression in Thymus (RPKM 36.2), Spleen (RPKM 31.0) and 9 other tissues See more
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Genomic context

See Nat2 in Genome Data Viewer
Location:
16p14
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (26974874..27005191, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (22207362..22238513, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (23960709..23991570, complement)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene pleckstrin and Sec7 domain containing 3 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene N-acetyltransferase 3 Neighboring gene high mobility group box 2, pseudogene 3 Neighboring gene golgin A4, pseudogene 1 Neighboring gene N-acetyltransferase 1 Neighboring gene small nucleolar RNA SNORA17

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Gene Ontology Provided by RGD

Component Evidence Code Pubs
located_in cytoplasm  

General protein information

Preferred Names
arylamine N-acetyltransferase 2
Names
AT-2
N-Acetyltransferase-2 (arylamine N-acetyltransferase)
N-acetyltransferase 2 (arylamine N-acetyltransferase)
N-acetyltransferase type 2
N-hydroxyarylamine O-acetyltransferase
NAT-2
arylamide acetylase 2
NP_446306.1
XP_006253069.1
XP_006253070.1
XP_006253071.1
XP_063131108.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053854.1NP_446306.1  arylamine N-acetyltransferase 2

    See identical proteins and their annotated locations for NP_446306.1

    Status: PROVISIONAL

    Source sequence(s)
    U01348
    UniProtKB/Swiss-Prot
    P50298
    UniProtKB/TrEMBL
    Q45G59
    Conserved Domains (1) summary
    pfam00797
    Location:20280
    Acetyltransf_2; N-acetyltransferase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    26974874..27005191 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006253008.4XP_006253070.1  arylamine N-acetyltransferase 2 isoform X1

    See identical proteins and their annotated locations for XP_006253070.1

    UniProtKB/TrEMBL
    A6KFK5, G3V9K9
    Related
    ENSRNOP00000087047.1, ENSRNOT00000101421.2
    Conserved Domains (1) summary
    pfam00797
    Location:20280
    Acetyltransf_2; N-acetyltransferase
  2. XM_063275038.1XP_063131108.1  arylamine N-acetyltransferase 2 isoform X1

    UniProtKB/TrEMBL
    A6KFK5, G3V9K9
  3. XM_006253007.3XP_006253069.1  arylamine N-acetyltransferase 2 isoform X1

    See identical proteins and their annotated locations for XP_006253069.1

    UniProtKB/TrEMBL
    A6KFK5, G3V9K9
    Conserved Domains (1) summary
    pfam00797
    Location:20280
    Acetyltransf_2; N-acetyltransferase
  4. XM_006253009.3XP_006253071.1  arylamine N-acetyltransferase 2 isoform X1

    See identical proteins and their annotated locations for XP_006253071.1

    UniProtKB/TrEMBL
    A6KFK5, G3V9K9
    Conserved Domains (1) summary
    pfam00797
    Location:20280
    Acetyltransf_2; N-acetyltransferase
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