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    Irs3 insulin receptor substrate 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 84021, updated on 9-Dec-2024

    Summary

    Official Symbol
    Irs3provided by RGD
    Official Full Name
    insulin receptor substrate 3provided by RGD
    Primary source
    RGD:69317
    See related
    EnsemblRapid:ENSRNOG00000001389 AllianceGenome:RGD:69317
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable insulin receptor binding activity and phosphatidylinositol 3-kinase binding activity. Predicted to be involved in insulin receptor signaling pathway. Predicted to be active in cytosol and plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 37.2), Liver (RPKM 29.5) and 9 other tissues See more
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    Genomic context

    See Irs3 in Genome Data Viewer
    Location:
    12q12
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (24689930..24692068)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (19053148..19055286)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (22120305..22125103)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 1 Neighboring gene enoyl CoA hydratase domain containing 2, pseudogene 1 Neighboring gene ArfGAP with FG repeats 2 Neighboring gene Sin3A-associated protein 25 Neighboring gene leucine rich repeats and calponin homology domain containing 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables insulin receptor binding  
    enables insulin receptor binding PubMed 
    enables phosphatidylinositol 3-kinase activator activity  
    enables phosphatidylinositol 3-kinase binding  
    Component Evidence Code Pubs
    is_active_in cytosol  
    is_active_in plasma membrane  

    General protein information

    Preferred Names
    insulin receptor substrate 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_032074.1NP_114463.1  insulin receptor substrate 3

      See identical proteins and their annotated locations for NP_114463.1

      Status: PROVISIONAL

      Source sequence(s)
      U93880
      UniProtKB/TrEMBL
      B1WBQ1, F7F0S6, O08724
      Related
      ENSRNOP00000001874.1, ENSRNOT00000001874.4
      Conserved Domains (3) summary
      cd01204
      Location:159273
      PTB_IRS; Insulin receptor substrate phosphotyrosine-binding domain (PTBi)
      cd01257
      Location:32132
      PH_IRS; Insulin receptor substrate (IRS) pleckstrin homology (PH) domain
      pfam00169
      Location:33131
      PH; PH domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      24689930..24692068
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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