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Atn1 atrophin 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29515, updated on 9-Dec-2024

Summary

Symbol
Atn1provided by RGD
Full Name
atrophin 1provided by RGD
Primary source
RGD:61832
See related
EnsemblRapid:ENSRNOG00000060594 AllianceGenome:RGD:61832
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Drpla
Summary
Enables JUN kinase binding activity. Involved in regulation of neuron differentiation. Located in cell leading edge; nucleus; and perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in dentatorubral-pallidoluysian atrophy and schizophrenia. Orthologous to human ATN1 (atrophin 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Kidney (RPKM 31.3), Adrenal (RPKM 28.4) and 9 other tissues See more
Orthologs
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Genomic context

See Atn1 in Genome Data Viewer
Location:
4q42
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (159240573..159254378, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (157554287..157568092, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (157267394..157281199, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene protein tyrosine phosphatase, non-receptor type 6 Neighboring gene U7 small nuclear RNA Neighboring gene gene rich cluster, C10 gene Neighboring gene uncharacterized LOC120102384 Neighboring gene enolase 2 Neighboring gene leucine rich repeat containing 23 Neighboring gene uncharacterized LOC134486638

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables JUN kinase binding PubMed 
enables protein binding PubMed 
enables protein domain specific binding  
enables protein domain specific binding  
enables transcription coactivator activity  
enables transcription coactivator activity  
enables transcription corepressor activity  
enables transcription corepressor activity  
enables transcription corepressor activity  
Process Evidence Code Pubs
involved_in cell killing  
acts_upstream_of_or_within cell killing  
involved_in cell migration  
involved_in cell migration  
involved_in determination of adult lifespan  
acts_upstream_of_or_within determination of adult lifespan  
involved_in maintenance of cell polarity  
involved_in maintenance of cell polarity  
involved_in male gonad development  
acts_upstream_of_or_within male gonad development  
involved_in multicellular organism growth  
acts_upstream_of_or_within multicellular organism growth  
involved_in negative regulation of transcription by RNA polymerase II  
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II  
involved_in negative regulation of transcription by RNA polymerase II  
involved_in neuron apoptotic process  
involved_in neuron apoptotic process  
involved_in positive regulation of DNA-templated transcription  
involved_in post-embryonic development  
acts_upstream_of_or_within post-embryonic development  
involved_in regulation of neuron differentiation PubMed 
involved_in response to food  
acts_upstream_of_or_within response to food  
involved_in spermatogenesis  
acts_upstream_of_or_within spermatogenesis  
Component Evidence Code Pubs
located_in anchoring junction  
located_in cell leading edge PubMed 
located_in cytoplasm  
located_in cytoplasm  
located_in nuclear matrix  
located_in nuclear matrix  
located_in nucleoplasm  
located_in nucleoplasm  
is_active_in nucleus  
located_in nucleus PubMed 
located_in nucleus  
located_in nucleus  
located_in perinuclear region of cytoplasm PubMed 

General protein information

Preferred Names
atrophin-1
Names
atrophin-1-like
dentatorubral pallidoluysian atrophy
dentatorubral-pallidoluysian atrophy protein homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001394346.1 → NP_001381275.1  atrophin-1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/Swiss-Prot
    P54258
    UniProtKB/TrEMBL
    A0A0G2JZ81, A6ILJ9
    Conserved Domains (1) summary
    pfam03154
    Location:1 → 1183
    Atrophin-1; Atrophin-1 family
  2. NM_017228.3 → NP_058924.2  atrophin-1

    See identical proteins and their annotated locations for NP_058924.2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/Swiss-Prot
    P54258
    UniProtKB/TrEMBL
    A0A0G2JZ81, A6ILJ9
    Related
    ENSRNOP00000070945.2, ENSRNOT00000088895.3
    Conserved Domains (1) summary
    pfam03154
    Location:1 → 1183
    Atrophin-1; Atrophin-1 family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    159240573..159254378 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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