U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Prmt3 protein arginine methyltransferase 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 89820, updated on 9-Dec-2024

    Summary

    Official Symbol
    Prmt3provided by RGD
    Official Full Name
    protein arginine methyltransferase 3provided by RGD
    Primary source
    RGD:620413
    See related
    EnsemblRapid:ENSRNOG00000014829 AllianceGenome:RGD:620413
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Hrmt1l3
    Summary
    Enables modified amino acid binding activity and protein-arginine omega-N asymmetric methyltransferase activity. Involved in dendritic spine morphogenesis and peptidyl-arginine methylation, to asymmetrical-dimethyl arginine. Predicted to be located in cytosol. Predicted to be active in nucleus. Biomarker of asthma. Orthologous to human PRMT3 (protein arginine methyltransferase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 111.1), Spleen (RPKM 108.2) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Prmt3 in Genome Data Viewer
    Location:
    1q22
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (108628899..108718803)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (99492712..99581774)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (105113595..105200253)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102546796 Neighboring gene HIV-1 Tat interactive protein 2 Neighboring gene U4 spliceosomal RNA Neighboring gene Glyceraldehyde-3-phosphate dehydrogenase, pseudogene 53 Neighboring gene solute carrier family 6 member 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in cytoplasm  
    located_in cytoplasm  
    located_in cytosol  
    located_in cytosol  
    is_active_in nucleus  

    General protein information

    Preferred Names
    protein arginine N-methyltransferase 3
    Names
    heterogeneous nuclear ribonucleoprotein methyltransferase-like 3
    heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 3
    protein arginine N-methyltransferase 3(hnRNP methyltransferase S. cerevisiae)-like 3
    NP_446009.1
    XP_038949056.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053557.2NP_446009.1  protein arginine N-methyltransferase 3

      See identical proteins and their annotated locations for NP_446009.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      O70467
      UniProtKB/TrEMBL
      A0A8L2QAU2, A6JBG4
      Related
      ENSRNOP00000020853.5, ENSRNOT00000020853.7
      Conserved Domains (2) summary
      cd02440
      Location:256356
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
      pfam12756
      Location:4897
      zf-C2H2_2; C2H2 type zinc-finger (2 copies)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      108628899..108718803
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039093128.2XP_038949056.1  protein arginine N-methyltransferase 3 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JW52, A0A8L2QAU2
      Related
      ENSRNOP00000069745.2, ENSRNOT00000079655.3
      Conserved Domains (2) summary
      cd02440
      Location:256356
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
      pfam12756
      Location:4897
      zf-C2H2_2; C2H2 type zinc-finger (2 copies)
    External link. Please review our privacy policy.