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Pdzd8 PDZ domain containing 8 [ Rattus norvegicus (Norway rat) ]

Gene ID: 308000, updated on 9-Dec-2024

Summary

Official Symbol
Pdzd8provided by RGD
Official Full Name
PDZ domain containing 8provided by RGD
Primary source
RGD:1308622
See related
EnsemblRapid:ENSRNOG00000009460 AllianceGenome:RGD:1308622
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Pdzk8
Summary
Predicted to enable lipid binding activity and metal ion binding activity. Predicted to be involved in several processes, including mitochondrial calcium ion homeostasis; mitochondrion-endoplasmic reticulum membrane tethering; and regulation of cell morphogenesis. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in mitochondria-associated endoplasmic reticulum membrane contact site. Orthologous to human PDZD8 (PDZ domain containing 8). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Brain (RPKM 156.3), Kidney (RPKM 129.7) and 9 other tissues See more
Orthologs
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Genomic context

See Pdzd8 in Genome Data Viewer
Location:
1q55
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (268435304..268492923, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (258449218..258506828, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (280458041..280515650, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene potassium two pore domain channel subfamily K member 18 Neighboring gene solute carrier family 18 member A2 Neighboring gene uncharacterized LOC134485265 Neighboring gene uncharacterized LOC120100068 Neighboring gene uncharacterized LOC134485266 Neighboring gene Emx2 opposite strand/antisense RNA

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables lipid binding  
enables metal ion binding  
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane  
is_active_in mitochondria-associated endoplasmic reticulum membrane contact site  
located_in mitochondria-associated endoplasmic reticulum membrane contact site  
located_in mitochondrion  

General protein information

Preferred Names
PDZ domain-containing protein 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107446.1NP_001100916.1  PDZ domain-containing protein 8

    See identical proteins and their annotated locations for NP_001100916.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473986
    UniProtKB/TrEMBL
    A6JI84, D3ZXY2
    Related
    ENSRNOP00000063181.1, ENSRNOT00000068082.3
    Conserved Domains (3) summary
    PRK03427
    Location:487645
    PRK03427; cell division protein ZipA; Provisional
    cd00992
    Location:363440
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd20825
    Location:836891
    C1_PDZD8; protein kinase C conserved region 1 (C1 domain) found in PDZ domain-containing protein 8 (PDZD8) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    268435304..268492923 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039110347.2XP_038966275.1  PDZ domain-containing protein 8 isoform X1

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