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Chmp2a charged multivesicular body protein 2A [ Rattus norvegicus (Norway rat) ]

Gene ID: 365191, updated on 9-Dec-2024

Summary

Official Symbol
Chmp2aprovided by RGD
Official Full Name
charged multivesicular body protein 2Aprovided by RGD
Primary source
RGD:1305050
See related
EnsemblRapid:ENSRNOG00000043328 AllianceGenome:RGD:1305050
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1305050
Summary
Predicted to enable phosphatidylcholine binding activity and protein domain specific binding activity. Predicted to be involved in several processes, including mitotic nuclear division; regulation of cell cycle process; and vacuolar transport. Predicted to be located in several cellular components, including bounding membrane of organelle; chromosome; and kinetochore microtubule. Predicted to be part of ESCRT III complex; membrane coat; and nuclear pore. Predicted to be active in multivesicular body. Orthologous to human CHMP2A (charged multivesicular body protein 2A). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Kidney (RPKM 463.4), Heart (RPKM 461.3) and 9 other tissues See more
Orthologs
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Genomic context

See Chmp2a in Genome Data Viewer
Location:
1q21
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (82731212..82735088, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (73660045..73662894, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (65540808..65543708)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108348449 Neighboring gene zinc finger and BTB domain containing 45 Neighboring gene tripartite motif-containing 28 Neighboring gene ubiquitin-conjugating enzyme E2M Neighboring gene myeloid zinc finger 1 Neighboring gene vomeronasal 1 receptor 55

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in autophagosome maturation  
involved_in autophagy  
involved_in establishment of protein localization  
involved_in exit from mitosis  
involved_in late endosome to lysosome transport  
involved_in membrane invagination  
involved_in midbody abscission  
involved_in mitotic metaphase chromosome alignment  
involved_in multivesicular body sorting pathway  
involved_in negative regulation of centriole elongation  
involved_in nuclear membrane reassembly  
involved_in nucleus organization  
involved_in plasma membrane repair  
involved_in positive regulation of exosomal secretion  
involved_in protein homooligomerization  
involved_in protein polymerization  
involved_in regulation of centrosome duplication  
involved_in regulation of mitotic spindle assembly  
involved_in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway  
involved_in viral budding from plasma membrane  
involved_in viral budding via host ESCRT complex  
Component Evidence Code Pubs
part_of ESCRT III complex  
located_in amphisome membrane  
located_in autophagosome membrane  
located_in chromatin  
located_in cytosol  
located_in kinetochore  
located_in kinetochore microtubule  
located_in lysosomal membrane  
part_of membrane coat  
located_in midbody  
located_in multivesicular body membrane  
located_in nuclear envelope  
part_of nuclear pore  
located_in plasma membrane  

General protein information

Preferred Names
charged multivesicular body protein 2a
Names
chromatin modifying protein 2A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108906.2NP_001102376.1  charged multivesicular body protein 2a

    See identical proteins and their annotated locations for NP_001102376.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A6KQL1, A6KQL2, B2RZB5
    Conserved Domains (1) summary
    pfam03357
    Location:17185
    Snf7
  2. NM_001416000.1NP_001402929.1  charged multivesicular body protein 2a

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A6KQL1, A6KQL2, B2RZB5
    Related
    ENSRNOP00000038229.3, ENSRNOT00000030931.7

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    82731212..82735088 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063269023.1XP_063125093.1  charged multivesicular body protein 2a isoform X1

  2. XM_063269019.1XP_063125089.1  charged multivesicular body protein 2a isoform X1

  3. XM_006228117.4XP_006228179.1  charged multivesicular body protein 2a isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZY10
    Related
    ENSRNOP00000082830.1, ENSRNOT00000097443.2
    Conserved Domains (1) summary
    pfam03357
    Location:17210
    Snf7
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