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Ccnb1 cyclin B1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25203, updated on 9-Dec-2024

Summary

Official Symbol
Ccnb1provided by RGD
Official Full Name
cyclin B1provided by RGD
Primary source
RGD:2291
See related
EnsemblRapid:ENSRNOG00000058539 AllianceGenome:RGD:2291
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables protein kinase binding activity. Involved in several processes, including cellular response to iron(III) ion; positive regulation of cardiac muscle cell proliferation; and regulation of protein phosphorylation. Predicted to be located in cytosol; membrane; and microtubule cytoskeleton. Predicted to be part of cyclin B1-CDK1 complex and outer kinetochore. Predicted to be active in cytoplasm; microtubule organizing center; and nucleus. Predicted to colocalize with mitochondrial matrix. Biomarker of visual epilepsy. Human ortholog(s) of this gene implicated in breast cancer and prostate cancer. Orthologous to human CCNB1 (cyclin B1). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Thymus (RPKM 332.4), Spleen (RPKM 240.8) and 9 other tissues See more
Orthologs
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Genomic context

See Ccnb1 in Genome Data Viewer
Location:
2q12
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (33646252..33655225, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (31912190..31921163, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (30782133..30791106, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485587 Neighboring gene centromere protein H Neighboring gene solute carrier family 30 member 5 Neighboring gene ribosomal protein L7a, pseudogene 13

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Gene Ontology Provided by RGD

Items 1 - 25 of 44
Process Evidence Code Pubs
involved_in G1/S transition of mitotic cell cycle  
involved_in cell division  
involved_in cellular response to fatty acid PubMed 
involved_in cellular response to hypoxia PubMed 
involved_in cellular response to iron(III) ion PubMed 
involved_in cellular response to organic cyclic compound PubMed 
involved_in digestive tract development PubMed 
involved_in in utero embryonic development  
acts_upstream_of_or_within in utero embryonic development  
involved_in mitotic cell cycle phase transition  
involved_in mitotic metaphase chromosome alignment  
involved_in mitotic metaphase chromosome alignment  
involved_in mitotic metaphase chromosome alignment  
involved_in mitotic spindle organization  
involved_in mitotic spindle organization  
involved_in negative regulation of gene expression PubMed 
involved_in negative regulation of meiotic cell cycle process involved in oocyte maturation  
involved_in negative regulation of protein phosphorylation PubMed 
involved_in oocyte maturation PubMed 
involved_in positive regulation of G2/M transition of mitotic cell cycle  
involved_in positive regulation of G2/M transition of mitotic cell cycle  
involved_in positive regulation of attachment of spindle microtubules to kinetochore  
involved_in positive regulation of attachment of spindle microtubules to kinetochore  
involved_in positive regulation of cardiac muscle cell proliferation PubMed 
acts_upstream_of_or_within positive regulation of cell cycle  
involved_in positive regulation of fibroblast proliferation  
acts_upstream_of_or_within positive regulation of fibroblast proliferation  
involved_in positive regulation of mRNA 3'-end processing PubMed 
involved_in positive regulation of mitochondrial ATP synthesis coupled electron transport  
involved_in positive regulation of mitochondrial ATP synthesis coupled electron transport  
involved_in positive regulation of mitotic cell cycle  
involved_in positive regulation of protein kinase activity PubMed 
acts_upstream_of_or_within protein phosphorylation  
involved_in protein-containing complex assembly PubMed 
involved_in regulation of chromosome condensation PubMed 
involved_in regulation of mitotic cell cycle spindle assembly checkpoint  
involved_in regulation of mitotic cell cycle spindle assembly checkpoint  
involved_in response to DDT PubMed 
involved_in response to mechanical stimulus PubMed 
involved_in response to toxic substance PubMed 
involved_in response to xenobiotic stimulus PubMed 
involved_in spermatogenesis PubMed 
involved_in tissue regeneration PubMed 
involved_in ventricular cardiac muscle cell development PubMed 
Items 1 - 25 of 44
Items 1 - 20 of 23
Component Evidence Code Pubs
located_in centrosome  
located_in centrosome  
located_in centrosome  
part_of cyclin B1-CDK1 complex  
part_of cyclin B1-CDK1 complex  
part_of cyclin B1-CDK1 complex  
is_active_in cytoplasm  
located_in cytoplasm  
located_in cytosol  
located_in cytosol  
located_in membrane  
located_in membrane  
is_active_in microtubule organizing center  
colocalizes_with mitochondrial matrix  
located_in mitochondrial matrix  
located_in mitochondrial matrix  
is_active_in nucleus  
located_in nucleus  
located_in nucleus  
part_of outer kinetochore  
part_of outer kinetochore  
located_in spindle pole  
located_in spindle pole  
Items 1 - 20 of 23

General protein information

Preferred Names
G2/mitotic-specific cyclin-B1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_171991.3NP_741988.1  G2/mitotic-specific cyclin-B1

    See identical proteins and their annotated locations for NP_741988.1

    Status: VALIDATED

    Source sequence(s)
    FN800625, FN800627, FN800629, JAXUCZ010000002
    UniProtKB/Swiss-Prot
    P30277
    UniProtKB/TrEMBL
    A0A8I6G7B8, A6I5B4
    Related
    ENSRNOP00000082369.2, ENSRNOT00000104772.2
    Conserved Domains (2) summary
    pfam00134
    Location:163288
    Cyclin_N; Cyclin, N-terminal domain
    pfam02984
    Location:290408
    Cyclin_C; Cyclin, C-terminal domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    33646252..33655225 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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