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    Ube2j1 ubiquitin-conjugating enzyme E2, J1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 297961, updated on 27-Dec-2024

    Summary

    Official Symbol
    Ube2j1provided by RGD
    Official Full Name
    ubiquitin-conjugating enzyme E2, J1provided by RGD
    Primary source
    RGD:1305067
    See related
    EnsemblRapid:ENSRNOG00000007434 AllianceGenome:RGD:1305067
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ubiquitin conjugating enzyme activity and ubiquitin protein ligase binding activity. Predicted to be involved in ERAD pathway; negative regulation of retrograde protein transport, ER to cytosol; and protein modification process. Predicted to act upstream of or within regulation of macrophage cytokine production; regulation of tumor necrosis factor production; and spermatid development. Predicted to be active in endoplasmic reticulum membrane and nucleus. Orthologous to human UBE2J1 (ubiquitin conjugating enzyme E2 J1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 242.0), Spleen (RPKM 213.4) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Ube2j1 in Genome Data Viewer
    Location:
    5q21
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (52218807..52237805)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (47422476..47441476)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (48274387..48292699)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene Ras-related GTP binding D Neighboring gene uncharacterized LOC108350947 Neighboring gene ribonuclease P/MRP subunit p38, pseudogene 1 Neighboring gene gamma-aminobutyric acid type A receptor subunit rho 2 Neighboring gene uncharacterized LOC120102852

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane  
    is_active_in nucleus  

    General protein information

    Preferred Names
    ubiquitin-conjugating enzyme E2 J1
    Names
    ubiquitin-conjugating enzyme E2, J1 (UBC6 homolog, yeast)
    NP_001100112.2
    XP_008761834.1
    XP_038965356.1
    XP_038965357.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106642.2NP_001100112.2  ubiquitin-conjugating enzyme E2 J1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A096MKH4, A0A8I6A9S4
      Related
      ENSRNOP00000090289.2, ENSRNOT00000110935.2
      Conserved Domains (1) summary
      cd00195
      Location:12119
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      52218807..52237805
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039109428.2XP_038965356.1  ubiquitin-conjugating enzyme E2 J1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A9S4
      Related
      ENSRNOP00000068517.3, ENSRNOT00000075992.4
      Conserved Domains (1) summary
      cd00195
      Location:1104
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    2. XM_039109429.2XP_038965357.1  ubiquitin-conjugating enzyme E2 J1 isoform X2

      UniProtKB/TrEMBL
      A6IIK6
      Related
      ENSRNOP00000112829.1, ENSRNOT00000156136.1
      Conserved Domains (1) summary
      cd00195
      Location:12119
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    3. XM_008763612.3XP_008761834.1  ubiquitin-conjugating enzyme E2 J1 isoform X3

      See identical proteins and their annotated locations for XP_008761834.1

      UniProtKB/TrEMBL
      A0A8I6A9S4, A6IIK5
      Conserved Domains (1) summary
      cd00195
      Location:12119
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
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