U.S. flag

An official website of the United States government

Slc1a6 solute carrier family 1 member 6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 84012, updated on 9-Dec-2024

Summary

Official Symbol
Slc1a6provided by RGD
Official Full Name
solute carrier family 1 member 6provided by RGD
Primary source
RGD:620340
See related
EnsemblRapid:ENSRNOG00000007509 AllianceGenome:RGD:620340
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
EAAT4
Summary
Enables high-affinity L-glutamate transmembrane transporter activity and monoatomic anion transmembrane transporter activity. Involved in L-glutamate import across plasma membrane. Located in plasma membrane. Part of membrane protein complex. Is active in parallel fiber to Purkinje cell synapse and postsynaptic membrane. Orthologous to human SLC1A6 (solute carrier family 1 member 6). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Restricted expression toward (RPKM 56.5) See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Slc1a6 in Genome Data Viewer
Location:
7q11
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (11492422..11521007, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (10841836..10870424, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (13730101..13758170, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 7 subfamily A member 38E Neighboring gene olfactory receptor family 7 subfamily C member 70 Neighboring gene uncharacterized LOC102549402 Neighboring gene tektin like 1 Neighboring gene caspase 14

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Clone Names

  • MGC114297

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables L-amino acid transmembrane transporter activity  
enables L-aspartate transmembrane transporter activity  
enables L-aspartate transmembrane transporter activity  
enables L-aspartate transmembrane transporter activity  
enables L-glutamate transmembrane transporter activity  
enables L-glutamate transmembrane transporter activity  
enables L-glutamate transmembrane transporter activity  
enables L-glutamate transmembrane transporter activity PubMed 
enables acidic amino acid transmembrane transporter activity  
enables glutamate:sodium symporter activity  
enables glutamate:sodium symporter activity  
enables glutamate:sodium symporter activity  
enables high-affinity L-glutamate transmembrane transporter activity PubMed 
enables metal ion binding  
enables monoatomic anion transmembrane transporter activity PubMed 
enables neutral L-amino acid transmembrane transporter activity  
enables symporter activity  
Process Evidence Code Pubs
involved_in L-alpha-amino acid transmembrane transport  
involved_in L-aspartate import across plasma membrane  
involved_in L-aspartate import across plasma membrane  
involved_in L-aspartate import across plasma membrane  
involved_in L-glutamate import across plasma membrane PubMed 
involved_in L-glutamate import across plasma membrane  
involved_in L-glutamate import across plasma membrane  
involved_in L-glutamate transmembrane transport  
involved_in L-glutamate transmembrane transport PubMed 
acts_upstream_of_or_within L-glutamate transmembrane transport  
involved_in acidic amino acid transport  
involved_in dicarboxylic acid transport  
involved_in establishment of localization in cell  
acts_upstream_of_or_within establishment of localization in cell  
involved_in monoatomic anion transmembrane transport  
involved_in neurotransmitter uptake  
involved_in neurotransmitter uptake  
involved_in neutral amino acid transport  
involved_in regulation of membrane potential  
acts_upstream_of_or_within regulation of membrane potential  
Component Evidence Code Pubs
located_in Golgi apparatus  
located_in Golgi apparatus  
located_in glutamatergic synapse  
is_active_in glutamatergic synapse  
located_in intermediate filament cytoskeleton  
located_in intermediate filament cytoskeleton  
located_in membrane  
located_in membrane  
part_of membrane protein complex PubMed 
is_active_in parallel fiber to Purkinje cell synapse PubMed 
is_active_in plasma membrane  
located_in plasma membrane PubMed 
located_in plasma membrane  
is_active_in postsynaptic membrane PubMed 
located_in presynaptic membrane  
is_active_in presynaptic membrane  

General protein information

Preferred Names
excitatory amino acid transporter 4
Names
high affinity aspartate/glutamate transporter
high-affinity neuronal glutamate transporter
sodium-dependent glutamate/aspartate transporter
solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032065.2NP_114454.2  excitatory amino acid transporter 4

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/Swiss-Prot
    O35921, P97683
    UniProtKB/TrEMBL
    Q7TSX6
    Related
    ENSRNOP00000096116.1, ENSRNOT00000108905.2
    Conserved Domains (1) summary
    pfam00375
    Location:55519
    SDF; Sodium:dicarboxylate symporter family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    11492422..11521007 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
External link. Please review our privacy policy.