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Dcbld2 discoidin, CUB and LCCL domain containing 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 155696, updated on 9-Dec-2024

Summary

Official Symbol
Dcbld2provided by RGD
Official Full Name
discoidin, CUB and LCCL domain containing 2provided by RGD
Primary source
RGD:620543
See related
EnsemblRapid:ENSRNOG00000055281 AllianceGenome:RGD:620543
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Esdn
Summary
Predicted to enable signaling receptor activity. Predicted to be involved in negative regulation of cell growth and wound healing. Predicted to be located in cell surface. Predicted to be active in plasma membrane. Orthologous to human DCBLD2 (discoidin, CUB and LCCL domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Heart (RPKM 401.0), Brain (RPKM 82.9) and 8 other tissues See more
Orthologs
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Genomic context

See Dcbld2 in Genome Data Viewer
Location:
11q12
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (55594691..55649113, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (42125525..42179927, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (44237814..44292884, complement)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene ferritin heavy chain-like Neighboring gene ST3 beta-galactoside alpha-2,3-sialyltransferase 6 Neighboring gene uncharacterized LOC108352323 Neighboring gene uncharacterized LOC120095647 Neighboring gene ribosomal protein S28 like 1 Neighboring gene mitogen activated protein kinase 3, pseudogene 3

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables signaling receptor activity  
Process Evidence Code Pubs
involved_in negative regulation of cell growth  
involved_in negative regulation of cell growth  
involved_in negative regulation of cell growth  
involved_in wound healing  
involved_in wound healing  
involved_in wound healing  
involved_in wound healing  
Component Evidence Code Pubs
located_in cell surface  
located_in cell surface  
located_in cell surface  
located_in membrane  
is_active_in plasma membrane  
located_in plasma membrane  
located_in plasma membrane  
located_in plasma membrane  

General protein information

Preferred Names
discoidin, CUB and LCCL domain-containing protein 2
Names
endothelial and smooth muscle cell-derived neuropilin-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_130419.2NP_569103.2  discoidin, CUB and LCCL domain-containing protein 2 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000011
    UniProtKB/Swiss-Prot
    Q91ZV2
    UniProtKB/TrEMBL
    A0A0G2JWS6
    Related
    ENSRNOP00000069998.2, ENSRNOT00000084060.3
    Conserved Domains (3) summary
    cd00041
    Location:72186
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00057
    Location:296448
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    cl02694
    Location:193275
    LCCL; LCCL domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    55594691..55649113 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039087921.2XP_038943849.1  discoidin, CUB and LCCL domain-containing protein 2 isoform X1

    Conserved Domains (3) summary
    cd00041
    Location:72186
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00057
    Location:296407
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    cl02694
    Location:193275
    LCCL; LCCL domain
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