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    Cacna2d1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25399, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cacna2d1provided by RGD
    Official Full Name
    calcium voltage-gated channel auxiliary subunit alpha2delta 1provided by RGD
    Primary source
    RGD:2247
    See related
    EnsemblRapid:ENSRNOG00000033531 AllianceGenome:RGD:2247
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    CCHLA2; Cacna2; DHSCCA
    Summary
    Enables voltage-gated calcium channel activity. Involved in calcium ion transmembrane transport; positive regulation of voltage-gated calcium channel activity; and regulation of membrane repolarization during action potential. Part of L-type voltage-gated calcium channel complex. Is active in glutamatergic synapse; postsynaptic membrane; and presynaptic active zone membrane. Biomarker of brain infarction. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 110. Orthologous to human CACNA2D1 (calcium voltage-gated channel auxiliary subunit alpha2delta 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 1317.2), Brain (RPKM 301.1) and 4 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Cacna2d1 in Genome Data Viewer
    Location:
    4q12
    Exon count:
    41
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (19902324..20330287, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (18950611..19374969, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (15706974..16130848, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene cadherin related family member 17 Neighboring gene uncharacterized LOC103692033 Neighboring gene hepatocyte growth factor Neighboring gene uncharacterized LOC134486713 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene pleiotropic regulator 1, pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in calcium ion transmembrane transport PubMed 
    involved_in calcium ion transmembrane transport  
    involved_in calcium ion transmembrane transport via high voltage-gated calcium channel PubMed 
    involved_in calcium ion transport  
    involved_in calcium ion transport PubMed 
    involved_in calcium ion transport into cytosol PubMed 
    involved_in cardiac muscle cell action potential involved in contraction  
    involved_in cardiac muscle cell action potential involved in contraction  
    involved_in cellular response to amyloid-beta  
    involved_in cellular response to amyloid-beta  
    involved_in membrane depolarization during bundle of His cell action potential  
    involved_in membrane depolarization during bundle of His cell action potential  
    involved_in positive regulation of voltage-gated calcium channel activity PubMed 
    involved_in regulation of calcium ion transmembrane transport via high voltage-gated calcium channel  
    involved_in regulation of calcium ion transmembrane transport via high voltage-gated calcium channel  
    acts_upstream_of_or_within regulation of calcium ion transport  
    involved_in regulation of calcium ion transport  
    involved_in regulation of heart rate by cardiac conduction  
    involved_in regulation of heart rate by cardiac conduction  
    involved_in regulation of membrane repolarization during action potential PubMed 
    involved_in regulation of ventricular cardiac muscle cell membrane repolarization  
    involved_in regulation of ventricular cardiac muscle cell membrane repolarization  
    Component Evidence Code Pubs
    located_in GABA-ergic synapse  
    is_active_in GABA-ergic synapse  
    part_of L-type voltage-gated calcium channel complex  
    part_of L-type voltage-gated calcium channel complex PubMed 
    part_of L-type voltage-gated calcium channel complex  
    part_of L-type voltage-gated calcium channel complex  
    located_in T-tubule  
    is_active_in glutamatergic synapse PubMed 
    part_of monoatomic ion channel complex  
    located_in neuronal dense core vesicle  
    is_active_in neuronal dense core vesicle  
    located_in plasma membrane  
    is_active_in postsynaptic membrane PubMed 
    is_active_in presynaptic active zone membrane PubMed 
    located_in presynaptic active zone membrane  
    is_active_in presynaptic active zone membrane  
    located_in sarcoplasmic reticulum  
    located_in sarcoplasmic reticulum  
    part_of voltage-gated calcium channel complex PubMed 
    part_of voltage-gated calcium channel complex  

    General protein information

    Preferred Names
    voltage-dependent calcium channel subunit alpha-2/delta-1
    Names
    Calcium channel subunit alpha 2 delta (dihydropyridine - sensitive L-type)
    calcium channel, voltage-dependent, alpha2/delta subunit 1
    voltage-gated calcium channel subunit alpha-2/delta-1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001110847.1NP_001104317.1  voltage-dependent calcium channel subunit alpha-2/delta-1 isoform 3 precursor

      See identical proteins and their annotated locations for NP_001104317.1

      Status: PROVISIONAL

      Source sequence(s)
      AF400662
      UniProtKB/Swiss-Prot
      P54290
      UniProtKB/TrEMBL
      Q8VHS9
      Related
      ENSRNOP00000103184.1, ENSRNOT00000140780.1
      Conserved Domains (5) summary
      cd01463
      Location:239417
      vWA_VGCC_like; VWA Voltage gated Calcium channel like: Voltage-gated calcium channels are a complex of five proteins: alpha 1, beta 1, gamma, alpha 2 and delta. The alpha 2 and delta subunits result from proteolytic processing of a single gene product and carries at ...
      pfam02743
      Location:446530
      Cache_1; Cache domain
      pfam08399
      Location:104223
      VWA_N; VWA N-terminal
      pfam08473
      Location:538622
      VGCC_alpha2; Neuronal voltage-dependent calcium channel alpha 2acd
      cl21471
      Location:537804
      RAMP_I_III; CRISPR/Cas system-associated RAMP superfamily protein
    2. NM_001110848.1NP_001104318.1  voltage-dependent calcium channel subunit alpha-2/delta-1 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001104318.1

      Status: PROVISIONAL

      Source sequence(s)
      AF486276
      UniProtKB/Swiss-Prot
      P54290
      UniProtKB/TrEMBL
      Q8CFG7
      Conserved Domains (5) summary
      cd01463
      Location:239417
      vWA_VGCC_like; VWA Voltage gated Calcium channel like: Voltage-gated calcium channels are a complex of five proteins: alpha 1, beta 1, gamma, alpha 2 and delta. The alpha 2 and delta subunits result from proteolytic processing of a single gene product and carries at ...
      pfam02743
      Location:446531
      Cache_1; Cache domain
      pfam08399
      Location:104223
      VWA_N; VWA N-terminal
      pfam08473
      Location:543627
      VGCC_alpha2; Neuronal voltage-dependent calcium channel alpha 2acd
      cl21471
      Location:623809
      RAMP_I_III; CRISPR/Cas system-associated RAMP superfamily protein
    3. NM_012919.3NP_037051.2  voltage-dependent calcium channel subunit alpha-2/delta-1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_037051.2

      Status: PROVISIONAL

      Source sequence(s)
      AF286488
      UniProtKB/Swiss-Prot
      P54290
      UniProtKB/TrEMBL
      F7F134, Q9ERS3
      Related
      ENSRNOP00000105396.1, ENSRNOT00000156499.1
      Conserved Domains (5) summary
      cd01463
      Location:239417
      vWA_VGCC_like; VWA Voltage gated Calcium channel like: Voltage-gated calcium channels are a complex of five proteins: alpha 1, beta 1, gamma, alpha 2 and delta. The alpha 2 and delta subunits result from proteolytic processing of a single gene product and carries at ...
      pfam02743
      Location:446531
      Cache_1; Cache domain
      pfam08399
      Location:104223
      VWA_N; VWA N-terminal
      pfam08473
      Location:543627
      VGCC_alpha2; Neuronal voltage-dependent calcium channel alpha 2acd
      cl21471
      Location:636816
      RAMP_I_III; CRISPR/Cas system-associated RAMP superfamily protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      19902324..20330287 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063285606.1XP_063141676.1  voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X3

      UniProtKB/Swiss-Prot
      P54290
      Related
      ENSRNOP00000074655.3, ENSRNOT00000082161.3
    2. XM_063285608.1XP_063141678.1  voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X5

      UniProtKB/Swiss-Prot
      P54290
    3. XM_063285607.1XP_063141677.1  voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X4

      UniProtKB/Swiss-Prot
      P54290
    4. XM_063285605.1XP_063141675.1  voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X2

      UniProtKB/Swiss-Prot
      P54290
    5. XM_063285604.1XP_063141674.1  voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1

      UniProtKB/Swiss-Prot
      P54290
    6. XM_063285611.1XP_063141681.1  voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X8

    7. XM_063285609.1XP_063141679.1  voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X6

    8. XM_063285610.1XP_063141680.1  voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X7

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